(Q34119143)

31 July 2017

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title

Mechanisms of cell-cycle checkpoints: at the crossroads of carcinogenesis and drug discovery (English)

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31 July 2017

1 reference

1 reference

Flatt PM

1

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31 July 2017

Pietenpol JA

series ordinal

2

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31 July 2017

language of work or name

English

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publication date

1 August 2000

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31 July 2017

published in

Drug Metabolism Reviews

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31 July 2017

volume

32

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31 July 2017

issue

3-4

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31 July 2017

page(s)

283-305

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Protein tyrosine kinase-mediated pathways in G protein-coupled receptor signaling.

31 July 2017

cites work

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Mechanisms by which genes encoding growth factors and growth factor receptors contribute to malignant transformation

21 January 2018

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Oncogene amplification and prognosis in breast cancer: Relationship with systemic treatment

21 January 2018

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Ras-induced transformation and signaling pathway

21 January 2018

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Cell cycle targets of Ras/Raf signalling

21 January 2018

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Accumulation of genetic alterations and their significance in each primary human cancer and cell line

21 January 2018

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Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.

21 January 2018

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Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods

21 January 2018

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myc function and regulation

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100102335

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100102335

The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc

21 January 2018

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Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src.

21 January 2018

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Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100102335

Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100102335

Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

The ornithine decarboxylase gene is a transcriptional target of c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Cellular transformation and malignancy induced by ras require c-jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Cyclin D1 and human neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

A novel cyclin encoded by a bcl1-linked candidate oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

D-type cyclin-dependent kinase activity in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Cyclins, Cdks, and cyclin kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Cumulative effect of phosphorylation of pRB on regulation of E2F activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Role of the retinoblastoma protein in the pathogenesis of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Nucleotide sequence and tissue distribution of mouse transforming growth factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Universal control mechanism regulating onset of M-phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

A complex containing p34cdc2 and cyclin B phosphorylates the nuclear lamin and disassembles nuclei of clam oocytes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

CP60: a microtubule-associated protein that is localized to the centrosome in a cell cycle-specific manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Checkpoints: controls that ensure the order of cell cycle events

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

The p53 pathway and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Definition of a consensus binding site for p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Oncogenic forms of p53 inhibit p53-regulated gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Sequence-specific transcriptional activation is essential for growth suppression by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Radiation-induced cell cycle arrest compromised by p21 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Inhibitors of mammalian G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Why are there so many CDK inhibitors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

The INK4A/ARF locus and its two gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

21 January 2018

Cdc2 regulatory factors

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

p53 regulates a G2 checkpoint through cyclin B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Mechanisms of G2 arrest in response to overexpression of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

p53 regulation of G(2) checkpoint is retinoblastoma protein dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Nuclear localization of cyclin B1 controls mitotic entry after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

How proteolysis drives the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Mitotic forces control a cell-cycle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Identification of a human mitotic checkpoint gene: hsMAD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Mutations of mitotic checkpoint genes in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

The cellular response to p53: the decision between life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Mechanisms of p53-induced apoptosis: in search of genes which are regulated during p53-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Essential role for p53-mediated transcription in E1A-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Induction of the growth inhibitor IGF-binding protein 3 by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Death receptors: signaling and modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Reactive oxygen species are downstream mediators of p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Involvement of p85 in p53-dependent apoptotic response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

A model for p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Mechanisms of p53-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Wild-type p53 negatively regulates the expression of a microtubule-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

p53 modulation of TFIIH-associated nucleotide excision repair activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

DNA repair, DNA replication, and UV mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

The specificity of p53 mutation spectra in sunlight induced human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

21 January 2018

DNA damage by mycotoxins

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

21 January 2018

The spindle checkpoint

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102335

21 January 2018

Identifiers

DOI

10.1081/DMR-100102335

1 reference

31 July 2017

1 reference