(Q34135694)

31 July 2017

title

Ligand-induced changes in hepatitis C virus NS5B polymerase structure (English)

1 reference

31 July 2017

1 reference

1 reference

Karen Rigat

1

1 reference

31 July 2017

Yi Wang

2

1 reference

31 July 2017

Min Ding

4

1 reference

31 July 2017

Xiaofan Zheng

5

1 reference

31 July 2017

Min Gao

8

1 reference

31 July 2017

Thomas W. Hudyma

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20813137

5 July 2024

Robert G. Gentles

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20813137

5 July 2024

Brett R. Beno

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20813137

5 July 2024

Susan B. Roberts

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20813137

5 July 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20813137

5 July 2024

publication date

9 September 2010

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full work available at URL

31 July 2017

https://api.elsevier.com/content/article/PII:S0166354210007011?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

https://api.elsevier.com/content/article/PII:S0166354210007011?httpAccept=text/plain

5 July 2024

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

5 July 2024

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31 July 2017

volume

88

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31 July 2017

issue

2

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31 July 2017

page(s)

197-206

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31 July 2017

1

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

The prevalence of hepatitis C virus infection in the United States, 1999 through 2002

5 July 2024

2

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection

5 July 2024

3

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

5 July 2024

The Protein Data Bank

5

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors

5 July 2024

6

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition

5 July 2024

7

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

A new protease activity assay using fluorescence polarization

5 July 2024

8

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

5 July 2024

9

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

5 July 2024

10

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase

5 July 2024

13

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

5 July 2024

14

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Treatment of chronic hepatitis C with PEGylated interferon and ribavirin

5 July 2024

15

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site

5 July 2024

16

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

An open and closed case for all polymerases.

5 July 2024

17

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Severe hepatocellular injury with apoptosis induced by a hepatitis C polymerase inhibitor

5 July 2024

18

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

A comparison of viral RNA-dependent RNA polymerases

5 July 2024

19

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109.

5 July 2024

20

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor

5 July 2024

22

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

5 July 2024

23

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Modulation of hepatitis C virus RNA-dependent RNA polymerase activity by structure-based site-directed mutagenesis

5 July 2024

25

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

5 July 2024

26

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

5 July 2024

Q27650541

27

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.

5 July 2024

28

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Mechanistic study of HCV polymerase inhibitors at individual steps of the polymerization reaction.

5 July 2024

29

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

5 July 2024

30

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors.

5 July 2024

31

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation

5 July 2024

32

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Recombinant viral RdRps can initiate RNA synthesis from circular templates

5 July 2024

33

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase

5 July 2024

34

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades

5 July 2024

35

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

5 July 2024

36

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition

5 July 2024

37

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase.

5 July 2024

38

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

A homogeneous, solid-phase assay for hepatitis C virus RNA-dependent RNA polymerase

5 July 2024

39

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2010.08.014

5 July 2024

Identifiers

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31 July 2017

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