(Q34164683)

31 July 2017

PI3K and mTOR signaling pathways in cancer: new data on targeted therapies (English)

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31 July 2017

Nicolas Chapuis

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Jerome Tamburini

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Jerome Tamburini

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Didier Bouscary

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Didier Bouscary

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author name string

Lise Willems

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31 July 2017

Catherine Lacombe

4

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31 July 2017

Patrick Mayeux

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31 July 2017

language of work or name

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1 April 2012

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31 July 2017

Current Oncology Reports

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31 July 2017

14

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31 July 2017

2

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31 July 2017

129-138

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https://scigraph.springernature.com/pub.10.1007/s11912-012-0227-y

31 July 2017

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mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

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Activation of mTORC2 by association with the ribosome

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

21 January 2018

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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

21 January 2018

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AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity

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Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors

21 January 2018

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Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.

21 January 2018

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Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin

21 January 2018

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mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling

21 January 2018

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

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mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected].

21 January 2018

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Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

21 January 2018

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PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML.

21 January 2018

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21 January 2018

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

21 January 2018

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NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

21 January 2018

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Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia.

21 January 2018

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The combination of RAD001 and NVP-BEZ235 exerts synergistic anticancer activity against non-small cell lung cancer in vitro and in vivo

21 January 2018

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Combination of PI3K/mTOR inhibitors: antitumor activity and molecular correlates

21 January 2018

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Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo.

21 January 2018

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A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity

21 January 2018

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Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

21 January 2018

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Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.

21 January 2018

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PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

21 January 2018

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-012-0227-Y

Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-012-0227-Y

Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-012-0227-Y

Nuclear phospho-Akt increase predicts synergy of PI3K inhibition and doxorubicin in breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-012-0227-Y

PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-012-0227-Y

The TORC1/TORC2 inhibitor, Palomid 529, reduces tumor growth and sensitizes to docetaxel and cisplatin in aggressive and hormone-refractory prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-012-0227-Y

Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-012-0227-Y

Akt and autophagy cooperate to promote survival of drug-resistant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-012-0227-Y

The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.

21 January 2018

1 reference

12 December 2020

Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo

1 reference

12 December 2020

The biological and therapeutic relevance of mRNA translation in cancer

1 reference

12 December 2020

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

1 reference

12 December 2020

mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells

1 reference

12 December 2020

Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1

1 reference

12 December 2020

Defining the role of TORC1/2 in multiple myeloma

1 reference

12 December 2020

10.1007/S11912-012-0227-Y

Identifiers

DOI

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Dimensions Publication ID

31 July 2017

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