(Q34186657)

English

Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line

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Europe PubMed Central

PubMed publication ID

31 July 2017

Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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Yanhua Wang

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Rongboa Zhao

2

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Europe PubMed Central

PubMed publication ID

31 July 2017

I David Goldman

3

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Europe PubMed Central

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31 July 2017

language of work or name

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publication date

1 April 2003

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Europe PubMed Central

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31 July 2017

Biochemical Pharmacology

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31 July 2017

65

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Europe PubMed Central

PubMed publication ID

31 July 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1163-1170

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase

1 reference

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The cellular pharmacology of methotrexate

1 reference

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Pemetrexed disodium, a novel antifolate with multiple targets

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Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma

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7 January 2021

Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis

1 reference

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7 January 2021

Resistance to tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines

1 reference

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7 January 2021

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

1 reference

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7 January 2021

Molecular and cellular biology of the human reduced folate carrier

1 reference

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A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.

1 reference

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7 January 2021

A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate

1 reference

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Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells

1 reference

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7 January 2021

Relationships between carrier-mediated transport of folate compounds by L1210 leukemia cells: evidence for multiplicity of entry routes with different kinetic properties expressed in plasma membrane vesicles.

1 reference

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7 January 2021

Carrier-mediated transport of folate compounds in L1210 cells. Initial rate kinetics and extent of duality of entry routes for folic acid and diastereomers of 5-methyltetrahydrohomofolate in the presence of physiological anions

1 reference

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7 January 2021

Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells

1 reference

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The reduced folate carrier in L1210 murine leukemia cells is a 58-kDa protein

1 reference

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Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates

1 reference

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7 January 2021

Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates

1 reference

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7 January 2021

Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900007-8

7 January 2021

Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites

1 reference

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7 January 2021

Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate

1 reference

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7 January 2021

Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells

1 reference

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7 January 2021

Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line

1 reference

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7 January 2021

Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase

1 reference

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7 January 2021

Glutamyl hydrolase and the multitargeted antifolate LY231514.

1 reference

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7 January 2021

Identifiers

10.1016/S0006-2952(03)00007-8

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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