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Therapeutic opportunities in polyglutamine disease
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11283667
retrieved
31 July 2017
review article
1 reference
stated in
Europe PubMed Central
title
Therapeutic opportunities in polyglutamine disease
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11283667
retrieved
31 July 2017
author name string
Hughes RE
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11283667
retrieved
31 July 2017
Olson JM
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
11283667
retrieved
31 July 2017
language of work or name
English
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publication date
1 April 2001
1 reference
stated in
Europe PubMed Central
PubMed ID
11283667
retrieved
31 July 2017
published in
Nature Medicine
1 reference
stated in
Europe PubMed Central
PubMed ID
11283667
retrieved
31 July 2017
volume
7
1 reference
stated in
Europe PubMed Central
PubMed ID
11283667
retrieved
31 July 2017
page(s)
419-423
1 reference
stated in
Europe PubMed Central
PubMed ID
11283667
retrieved
31 July 2017
issue
4
1 reference
stated in
Europe PubMed Central
PubMed ID
11283667
retrieved
31 July 2017
exact match
https://scigraph.springernature.com/pub.10.1038/86486
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Glutamine repeats and neurodegeneration
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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inferred from DOI database lookup
Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease
1 reference
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Crossref
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7 January 2021
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Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract
1 reference
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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Identification of genes that modify ataxin-1-induced neurodegeneration.
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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Genetic suppression of polyglutamine toxicity in Drosophila
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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Ubiquitin, cellular inclusions and their role in neurodegeneration
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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inferred from DOI database lookup
Protein fate in neurodegenerative proteinopathies: polyglutamine diseases join the (mis)fold
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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inferred from DOI database lookup
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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inferred from DOI database lookup
A huntingtin-associated protein enriched in brain with implications for pathology
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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inferred from DOI database lookup
SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
retrieved
7 January 2021
based on heuristic
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Huntingtin interacts with a family of WW domain proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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inferred from DOI database lookup
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
CREB-binding protein sequestration by expanded polyglutamine
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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inferred from DOI database lookup
Transcriptional dysregulation in Huntington's disease
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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inferred from DOI database lookup
Decreased expression of striatal signaling genes in a mouse model of Huntington's disease
1 reference
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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inferred from DOI database lookup
Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea
1 reference
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids
1 reference
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7 January 2021
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Replicating Huntington's disease phenotype in experimental animals
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
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Oxidative stress, glutamate, and neurodegenerative disorders
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.
1 reference
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reference URL
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7 January 2021
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inferred from DOI database lookup
Influence of lamotrigine on progression of early Huntington disease: a randomized clinical trial
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Cognitive, behavioral, and motor effects of the NMDA antagonist ketamine in Huntington's disease
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
A controlled clinical trial of baclofen as protective therapy in early Huntington's disease
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inflammation and Alzheimer's disease
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The influence of huntingtin protein size on nuclear localization and cellular toxicity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase-8 is required for cell death induced by expanded polyglutamine repeats.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
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1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
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Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
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7 January 2021
based on heuristic
inferred from DOI database lookup
Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F86486
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/86486
1 reference
stated in
Europe PubMed Central
PubMed ID
11283667
retrieved
31 July 2017
PubMed ID
11283667
1 reference
stated in
Europe PubMed Central
PubMed ID
11283667
retrieved
31 July 2017
ResearchGate publication ID
12049400
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