(Q34224429)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

1 reference

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Jonathan D. Mosley

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

author name string

S Goswami

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

S Stocker

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

M Kubo

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

R Castro

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

J A Mefford

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

C Wen

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

X Liang

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

J Witte

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

C Brett

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

S Maeda

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

M D Simpson

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

M M Hedderson

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

R L Davis

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

D M Roden

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

K M Giacomini

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

R M Savic

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

language of work or name

English

0 references

publication date

22 May 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

Clinical Pharmacology & Therapeutics

19 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

volume

96

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

page(s)

370-379

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

Hepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene

19 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.

5 July 2018

1 reference

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Pharmacogenomics knowledge for personalized medicine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Metformin pathways: pharmacokinetics and pharmacodynamics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Genotype imputation with thousands of genomes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Quantifying the Effect of Metformin Treatment and Dose on Glycemic Control

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

A common 5'-UTR variant in MATE2-K is associated with poor response to metformin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

FIMO: scanning for occurrences of a given motif

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Clinical Pharmacokinetics of Metformin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

A flexible and accurate genotype imputation method for the next generation of genome-wide association studies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study

5 July 2018

1 reference

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National trends in treatment of type 2 diabetes mellitus, 1994-2007

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Metformin therapy and clinical uses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Polymorphism in human organic cation transporters and metformin action

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

PLINK: a tool set for whole-genome association and population-based linkage analyses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Characterization of the Basal promoter element of human organic cation transporter 2 gene.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

The role of HNF4A variants in the risk of type 2 diabetes

5 July 2018

1 reference

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Transcriptional regulation of murine Slc22a1 (Oct1) by peroxisome proliferator agonist receptor-alpha and -gamma

5 July 2018

1 reference

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Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells.

5 July 2018

1 reference

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171106

The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

5 July 2018

1 reference

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Efficacy, dose-response relationship and safety of once-daily extended-release metformin (Glucophage XR) in type 2 diabetic patients with inadequate glycaemic control despite prior treatment with diet and exercise: results from two double-blind, pla

21 January 2018

1 reference

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Efficacy of metformin in type II diabetes: results of a double-blind, placebo-controlled, dose-response trial.

21 January 2018

1 reference

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Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.109

Genetic variants of the organic cation transporter 2 influence the disposition of metformin

21 January 2018

1 reference

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OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.109

Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.109

Functional characterization of MATE2-K genetic variants and their effects on metformin pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.109

Rifampin enhances the glucose-lowering effect of metformin and increases OCT1 mRNA levels in healthy participants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.109

Analytical goals for HbA1c: are HbA1c results good enough for optimal use?

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24853734

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Initial monotherapy with either metformin or sulphonylureas often fails to achieve or maintain current glycaemic goals in patients with Type 2 diabetes in UK primary care

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24853734

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CLPT.2014.109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

PubMed publication ID

24853734

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24853734%20AND%20SRC:MED&resulttype=core&format=json