(Q34270117)

1 August 2017

title

Imidazolopiperazines: lead optimization of the second-generation antimalarial agents (English)

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1 August 2017

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Elizabeth A Winzeler

28

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author name string

Advait Nagle

1

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1 August 2017

Tao Wu

2

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1 August 2017

Kelli Kuhen

3

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1 August 2017

Kerstin Gagaring

4

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1 August 2017

Rachel Borboa

5

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1 August 2017

Caroline Francek

6

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1 August 2017

Zhong Chen

7

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1 August 2017

David Plouffe

8

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1 August 2017

Xuena Lin

9

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1 August 2017

Christopher Caldwell

10

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1 August 2017

Jared Ek

11

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1 August 2017

Suzanne Skolnik

12

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1 August 2017

Fenghua Liu

13

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1 August 2017

Jianling Wang

14

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1 August 2017

Jonathan Chang

15

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1 August 2017

Chun Li

16

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1 August 2017

Bo Liu

17

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1 August 2017

Thomas Hollenbeck

18

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1 August 2017

Tove Tuntland

19

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1 August 2017

John Isbell

20

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1 August 2017

Tiffany Chuan

21

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1 August 2017

Philip B Alper

22

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1 August 2017

Christoph Fischli

23

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1 August 2017

Reto Brun

24

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1 August 2017

Suresh B Lakshminarayana

25

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1 August 2017

Matthias Rottmann

26

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1 August 2017

Thierry T Diagana

27

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1 August 2017

Richard Glynne

29

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1 August 2017

David C Tully

30

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1 August 2017

Arnab K Chatterjee

31

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1 August 2017

language of work or name

English

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publication date

23 April 2012

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Journal of Medicinal Chemistry

1 August 2017

published in

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1 August 2017

volume

55

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1 August 2017

issue

9

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1 August 2017

page(s)

4244-4273

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Imidazolopiperazines: hit to lead optimization of new antimalarial agents.

1 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Road towards new antimalarials - overview of the strategies and their chemical progress

6 July 2018

1 reference

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Spiroindolones, a potent compound class for the treatment of malaria

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Cell-based optimization of novel benzamides as potential antimalarial leads

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

6 July 2018

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Snapshot PK: a rapid rodent in vivo preclinical screening approach.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Diversification of the three-component coupling of 2-aminoheterocycles, aldehydes, and isonitriles: efficient parallel synthesis of a diverse and druglike library of imidazo- and tetrahydroimidazo[1,2-a] heterocycles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

QPatch: the past, present and future of automated patch clamp

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Cell culture-based models for intestinal permeability: a critique

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

High throughput assay technologies for ion channel drug discovery.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Identification of an antimalarial synthetic trioxolane drug development candidate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Antimalarial drug discovery: efficacy models for compound screening

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Influence of microsomal concentration on apparent intrinsic clearance: implications for scaling in vitro data.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Human malaria parasites in continuous culture

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

The 'do unto others' malaria vaccine

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Metabolic assessment in liver microsomes by co-activating cytochrome P450s and UDP-glycosyltransferases

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350218

Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22524250

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

PAMPA--critical factors for better predictions of absorption

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22524250

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM300041E

1 reference

1 August 2017

1 reference

1 August 2017

1 reference