(Q34276700)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

review article

1 reference

title

Resistance to antifungals that target CYP51 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Andrew Warrilow

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Claire L Price

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Jonathan Mullins

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

author name string

Diane E Kelly

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Steven L Kelly

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

publication date

27 August 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

Journal of Chemical Biology

21 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

page(s)

143-161

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s12154-014-0121-1

21 February 2020

exact match

0 references

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Discovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossing

6 July 2018

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Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults

6 July 2018

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Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control

6 July 2018

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Azole preexposure affects the Aspergillus fumigatus population in patients

6 July 2018

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Molecular epidemiology of Aspergillus fumigatus isolates harboring the TR34/L98H azole resistance mechanism.

6 July 2018

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Identification of novel genes conferring altered azole susceptibility in Aspergillus fumigatus

6 July 2018

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Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus

6 July 2018

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Global burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis

6 July 2018

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S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole.

6 July 2018

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Antifungal resistance and new strategies to control fungal infections

6 July 2018

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Identification of a Cryptococcus neoformans cytochrome P450 lanosterol 14α-demethylase (Erg11) residue critical for differential susceptibility between fluconazole/voriconazole and itraconazole/posaconazole

6 July 2018

1 reference

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High prevalence of azole-resistant Aspergillus fumigatus in adults with cystic fibrosis exposed to itraconazole.

6 July 2018

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Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.

6 July 2018

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Clinical implications of azole resistance in Aspergillus fumigatus, The Netherlands, 2007-2009.

6 July 2018

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Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter

6 July 2018

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Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola

6 July 2018

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Grapevine powdery mildew (Erysiphe necator): a fascinating system for the study of the biology, ecology and epidemiology of an obligate biotroph

6 July 2018

1 reference

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Amino acid substitutions at the major insertion loop of Candida albicans sterol 14alpha-demethylase are involved in fluconazole resistance.

6 July 2018

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Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene

6 July 2018

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6 July 2018

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Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

6 July 2018

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Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance.

6 July 2018

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Impact of recently emerged sterol 14{alpha}-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivity

6 July 2018

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Aspergillus fumigatus strains with mutations in the cyp51A gene do not always show phenotypic resistance to itraconazole, voriconazole, or posaconazole

6 July 2018

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Propiconazole induces alterations in the hepatic metabolome of mice: relevance to propiconazole-induced hepatocarcinogenesis

6 July 2018

1 reference

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Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals

6 July 2018

1 reference

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Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.

6 July 2018

1 reference

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Identification and characterization of four azole-resistant erg3 mutants of Candida albicans

6 July 2018

1 reference

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Epidemiology of invasive candidiasis

6 July 2018

1 reference

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Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.

6 July 2018

1 reference

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Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).

6 July 2018

1 reference

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Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma

6 July 2018

1 reference

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Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

6 July 2018

1 reference

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A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes

6 July 2018

1 reference

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Heterologous expression of mutated eburicol 14alpha-demethylase (CYP51) proteins of Mycosphaerella graminicola to assess effects on azole fungicide sensitivity and intrinsic protein function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature.

6 July 2018

1 reference

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Structural basis of human CYP51 inhibition by antifungal azoles

6 July 2018

1 reference

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Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole

6 July 2018

1 reference

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Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea

6 July 2018

1 reference

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Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

6 July 2018

1 reference

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Pulmonary aspergillosis in patients with chronic obstructive pulmonary disease: incidence, risk factors, and outcome

6 July 2018

1 reference

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Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure

6 July 2018

1 reference

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Interaction of Mycobacterium tuberculosis CYP130 with Heterocyclic Arylamines

6 July 2018

1 reference

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Determinants of mortality in non-neutropenic ICU patients with candidaemia

6 July 2018

1 reference

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The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry

6 July 2018

1 reference

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Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles

6 July 2018

1 reference

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Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase

6 July 2018

1 reference

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The epidemiology of Candida colonization and invasive candidiasis in a surgical intensive care unit where fluconazole prophylaxis is utilized: follow-up to a randomized clinical trial

6 July 2018

1 reference

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Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

6 July 2018

1 reference

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Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism

6 July 2018

1 reference

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Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase

6 July 2018

1 reference

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Epidemiological trends in skin mycoses worldwide

6 July 2018

1 reference

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Pramiconazole, a triazole compound for the treatment of fungal infections.

6 July 2018

1 reference

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Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth

6 July 2018

1 reference

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Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51).

6 July 2018

1 reference

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Fusarium infections in immunocompromised patients

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

6 July 2018

Vulvovaginal candidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Essential gene identification and drug target prioritization in Aspergillus fumigatus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Determinants of disease presentation and outcome during cryptococcosis: the CryptoA/D study

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Voriconazole : a review of its use in the management of invasive fungal infections

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Induction of cytochrome P450 1A1 by ketoconazole and itraconazole but not fluconazole in murine and human hepatoma cell lines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Epidemiology of invasive candidiasis: a persistent public health problem

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Drug evaluation: BAL-8557--a novel broad-spectrum triazole antifungal.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Invasive candidiasis in immunocompromised hospitalized patients.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Changing patterns and trends in systemic fungal infections

6 July 2018

1 reference

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Cytochrome P4501A induction caused by the imidazole derivative Prochloraz in a rainbow trout cell line.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Malassezia Baillon, emerging clinical yeasts.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Differences in interactions between azole drugs related to modifications in the 14-alpha sterol demethylase gene (cyp51A) of Aspergillus fumigatus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Global cancer statistics, 2002

6 July 2018

1 reference

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Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua)

6 July 2018

1 reference

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Skin diseases associated with Malassezia species

6 July 2018

1 reference

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In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Application of real-time quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Voriconazole for serious fungal infections.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

History of the development of azole derivatives

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

In vitro and in vivo activities of the novel azole antifungal agent r126638.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

The biodiversity of microbial cytochromes P450.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Voriconazole: a new triazole antifungal agent

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Mechanisms of fungal resistance: an overview

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Trends in antifungal susceptibility of Candida spp. isolated from pediatric and adult patients with bloodstream infections: SENTRY Antimicrobial Surveillance Program, 1997 to 2000.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Opportunistic fungal infections in the critically ill.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Clinical presentation, natural history, and cumulative death rates of 230 adults with primary cryptococcal meningitis in Zambian AIDS patients treated under local conditions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Crystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Strain identification of Trichophyton rubrum by specific amplification of subrepeat elements in the ribosomal DNA nontranscribed spacer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

The R467K amino acid substitution in Candida albicans sterol 14alpha-demethylase causes drug resistance through reduced affinity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Accumulation of 3-ketosteroids induced by itraconazole in azole-resistant clinical Candida albicans isolates

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

A novel ATP-binding cassette transporter involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

In vitro activity of a new oral triazole, BMS-207147 (ER-30346)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

A mutation in the 14 alpha-demethylase gene of Uncinula necator that correlates with resistance to a sterol biosynthesis inhibitor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Itraconazole resistance in Aspergillus fumigatus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Antifungal agents: an overview. Part I.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Ketoconazole Blocks Testosterone Synthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Ketoconazole Blocks Adrenal Steroid Synthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Overview of medically important antifungal azole derivatives

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Trends and patterns of opportunistic diseases in Danish AIDS patients 1980-1990.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

The low-spin/high-spin transition equilibrium of camphor-bound cytochrome P-450. Effects of medium and temperature on equilibrium data

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Antimycotic imidazoles. Part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

27 Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Environmental fungicides and triazole resistance in Aspergillus.

6 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

In vitro activity of ravuconazole against Zygomycetes, Scedosporium and Fusarium isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

In vitro activity of a new triazole BAL4815, the active component of BAL8557 (the water-soluble prodrug), against Aspergillus spp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Synthesis and in vitro and in vivo structure-activity relationships of novel antifungal triazoles for dermatology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Evaluation of fluconazole resistance mechanisms in candida albicans clinical isolates from HIV-infected patients in Brazil

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Effects of Y132H and F145L substitutions on the activity, azole resistance and spectral properties of Candida albicans sterol 14-demethylase P450 (CYP51): a live example showing the selection of altered P450 through interaction with environmental co

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Azole resistance in Aspergillus: a growing public health menace

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009.

21 January 2018

1 reference

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Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

High-level expression of cyp51B in azole-resistant clinical Aspergillus fumigatus isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

In vitro-in vivo correlation of voriconazole resistance due to G448S mutation (cyp51A gene) in Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

21 January 2018

Cryptococcal meningitis.

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Resistant P45051A1 activity in azole antifungal tolerant Cryptococcus neoformans from AIDS patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Drug resistance in Cryptococcus neoformans.

21 January 2018

1 reference

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Functional expression and characterization of CYP51 from dandruff-causing Malassezia globosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Increase in resistance to fluconazole and itraconazole in Trichophyton rubrum clinical isolates by sequential passages in vitro under drug pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Analysis of the CYP51 gene and encoded protein in propiconazole-resistant isolates of Mycosphaerella fijiensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

PdMLE1, a specific and active transposon acts as a promoter and confers Penicillium digitatum with DMI resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

The 14alpha-Demethylasse(CYP51A1) Gene is Overexpressed in Venturia inaequalis Strains Resistant to Myclobutanil

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

A novel substitution I381V in the sterol 14alpha-demethylase (CYP51) of Mycosphaerella graminicola is differentially selected by azole fungicides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Multiple mechanisms account for resistance to sterol 14α-demethylation inhibitors in field isolates of Mycosphaerella graminicola

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

PCR cloning and detection of point mutations in the eburicol 14alpha-demethylase (CYP51) gene from Erysiphe graminis f. sp. hordei, a "recalcitrant" fungus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Sequence variation in the CYP51 gene of Blumeria graminis associated with resistance to sterol demethylase inhibiting fungicides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Molecular design of two sterol 14alpha-demethylase homology models and their interactions with the azole antifungals ketoconazole and bifonazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

A three-dimensional model of lanosterol 14alpha-demethylase of Candida albicans and its interaction with azole antifungals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Endocrine-disrupting properties in vivo of widely used azole fungicides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Occurrence and molecular characterization of strobilurin resistance in cucumber powdery mildew and downy mildew

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Fungal echinocandin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

QoI resistance emerged independently at least 4 times in European populations of Mycosphaerella graminicola

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12154-014-0121-1

Occurrence of oral lesions in relation to clinical and immunological status among HIV-infected adult Tanzanians

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Hepatic injury associated with ketoconazole therapy. Analysis of 33 cases

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182338

Activity of newer triazoles against Histoplasma capsulatum from patients with AIDS who failed fluconazole

28 October 2018

1 reference

12 December 2020

Mutations in the CYP51 gene correlated with changes in sensitivity to sterol 14 alpha-demethylation inhibitors in field isolates of Mycosphaerella graminicola

1 reference

12 December 2020

Long-term outcome of AIDS-associated cryptococcosis in the era of combination antiretroviral therapy

1 reference

12 December 2020

Drug-induced gynecomastia

1 reference

12 December 2020

The structure-function relationship of the Aspergillus fumigatuscyp51A L98H conversion by site-directed mutagenesis: the mechanism of L98H azole resistance

1 reference

12 December 2020

The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity

1 reference

12 December 2020

Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug

1 reference

12 December 2020

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

1 reference

12 December 2020

The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase of Candida albicans (other names are: lanosterol 14 alpha-demethylase, P-45014DM, and CYP51)

1 reference

12 December 2020

Orchard factors associated with resistance and cross resistance to sterol demethylation inhibitor fungicides in populations of Venturia inaequalis from Pennsylvania

1 reference

12 December 2020

Ligand interactions with cytochrome P-450. I. Binding of primary amines

1 reference

12 December 2020

The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity

1 reference

12 December 2020

Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?

1 reference

12 December 2020

Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains

1 reference

12 December 2020

Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype

1 reference

12 December 2020

Resistance mechanisms in fluconazole-resistant Candida albicans isolates from vaginal candidiasis

1 reference

12 December 2020

In vitro activities of four antifungal drugs against Trichophyton rubrum isolates exhibiting resistance to fluconazole

1 reference

12 December 2020

1 reference

12 December 2020

10.1007/S12154-014-0121-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

21 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25320648%20AND%20SRC:MED&resulttype=core&format=json