(Q34283464)

1 August 2017

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title

The INK4A/ARF locus: role in cell cycle control and apoptosis and implications for glioma growth (English)

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1 August 2017

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Ivanchuk SM

1

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1 August 2017

Mondal S

series ordinal

2

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1 August 2017

Dirks PB

series ordinal

3

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1 August 2017

Rutka JT

series ordinal

4

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1 August 2017

publication date

1 February 2001

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Journal of Neuro-Oncology

1 August 2017

published in

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1 August 2017

volume

51

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1 August 2017

issue

3

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1 August 2017

page(s)

219-229

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Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein

1 August 2017

cites work

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12 December 2020

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

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12 December 2020

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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12 December 2020

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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12 December 2020

INK4d-deficient mice are fertile despite testicular atrophy

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12 December 2020

Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product

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12 December 2020

Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4

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12 December 2020

Regulation of cyclin dependent kinase inhibitor proteins during neonatal cerebella development

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12 December 2020

A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice

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12 December 2020

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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12 December 2020

Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function

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12 December 2020

Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population

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12 December 2020

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

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12 December 2020

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

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12 December 2020

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

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12 December 2020

A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies.

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12 December 2020

Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status

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12 December 2020

p16INK4A participates in a G1 arrest checkpoint in response to DNA damage

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12 December 2020

Role of the INK4a locus in tumor suppression and cell mortality.

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12 December 2020

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

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12 December 2020

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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12 December 2020

Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities.

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12 December 2020

E1A signaling to p53 involves the p19(ARF) tumor suppressor

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12 December 2020

Restoration of growth arrest by p16INK4, p21WAF1, pRB, and p53 is dependent on the integrity of the endogenous cell-cycle control pathways in human glioblastoma cell lines

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12 December 2020

The retinoblastoma protein and cell cycle control

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12 December 2020

A novel p16INK4A transcript

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12 December 2020

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene

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12 December 2020

Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells.

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12 December 2020

Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes

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12 December 2020

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

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12 December 2020

p53, the cellular gatekeeper for growth and division

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12 December 2020

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma.

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12 December 2020

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

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12 December 2020

The role of alpha v-integrins in tumour progression and metastasis

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12 December 2020

Nucleolar Arf sequesters Mdm2 and activates p53

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12 December 2020

Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors

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12 December 2020

Retinoic acid and the cyclin dependent kinase inhibitors synergistically alter proliferation and morphology of U343 astrocytoma cells

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12 December 2020

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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12 December 2020

Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues

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12 December 2020

Induction of senescence in human malignant glioma cells by p16INK4A.

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12 December 2020

Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro

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12 December 2020

CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

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12 December 2020

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

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12 December 2020

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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12 December 2020

Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines

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12 December 2020

Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

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12 December 2020

Tumor-suppressor p53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain: comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16Ink4a, cyclin G1, and the proto-oncogene

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12 December 2020

The INK4 family of cell cycle inhibitors in cancer

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12 December 2020

Characterization of the murine p19(ARF) promoter CpG island and its methylation pattern in primary lymphomas.

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12 December 2020

CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.

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12 December 2020

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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12 December 2020

Functional analysis of wild-type and malignant glioma derived CDKN2Abeta alleles: evidence for an RB-independent growth suppressive pathway

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12 December 2020

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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12 December 2020

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

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12 December 2020

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

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12 December 2020

The p16INK4a/CDKN2A tumor suppressor and its relatives.

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12 December 2020

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

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12 December 2020

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

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12 December 2020

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

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12 December 2020

The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts

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12 December 2020

p16 and p16 beta are potent growth suppressors of head and neck squamous carcinoma cells in vitro

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12 December 2020

Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb.

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12 December 2020

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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12 December 2020

Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

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12 December 2020

Cloning and characterization of murine p16INK4a and p15INK4b genes

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12 December 2020

Complex structure and regulation of the P16 (MTS1) locus

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12 December 2020

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

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12 December 2020

Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6

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12 December 2020

Deletion of p16 and p15 genes in brain tumors

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12 December 2020

A cell cycle regulator potentially involved in genesis of many tumor types

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12 December 2020

Identifiers

DOI

10.1023/A:1010632309113

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Dimensions Publication ID

1 August 2017

1000906124

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