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Engineered Fc based antibody domains and fragments as novel scaffolds
scientific article
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
24792384
retrieved
1 August 2017
title
Engineered Fc based antibody domains and fragments as novel scaffolds
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
24792384
retrieved
1 August 2017
main subject
antibody
1 reference
based on heuristic
inferred from title
author
Tianlei Ying
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4185235
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24792384%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
author name string
Rui Gong
series ordinal
2
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Europe PubMed Central
PMC publication ID
4185235
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24792384%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
Tina W Ju
series ordinal
3
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Europe PubMed Central
PMC publication ID
4185235
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24792384%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
Ponraj Prabakaran
series ordinal
4
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Europe PubMed Central
PMC publication ID
4185235
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24792384%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
Dimiter S Dimitrov
series ordinal
5
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PMC publication ID
4185235
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24792384%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
language of work or name
English
0 references
publication date
2 May 2014
1 reference
stated in
Europe PubMed Central
PubMed publication ID
24792384
retrieved
1 August 2017
published in
Biochimica et Biophysica Acta
1 reference
stated in
Europe PubMed Central
PMC publication ID
4185235
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24792384%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
volume
1844
1 reference
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Europe PubMed Central
PMC publication ID
4185235
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24792384%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
issue
11
1 reference
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Europe PubMed Central
PMC publication ID
4185235
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24792384%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
page(s)
1977-1982
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Europe PubMed Central
PMC publication ID
4185235
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24792384%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
cites work
Chemically programmed antibodies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
An Fc domain protein-small molecule conjugate as an enhanced immunomodulator
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Antibody V and C domain sequence, structure, and interaction analysis with special reference to IMGT®.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Stability engineering of the human antibody repertoire
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Engineered antibody variable and constant domains as therapeutic candidates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Engineered soluble monomeric IgG1 CH3 domain: generation, mechanisms of function, and implications for design of biological therapeutics.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Discovery of novel candidate therapeutics and diagnostics based on engineered human antibody domains.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
N-terminal truncation of an isolated human IgG1 CH2 domain significantly increases its stability and aggregation resistance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Bispecific engineered antibody domains (nanoantibodies) that interact noncompetitively with an HIV-1 neutralizing epitope and FcRn
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Pharmacokinetics of engineered human monomeric and dimeric CH2 domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Soluble monomeric IgG1 Fc.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Engineering aggregation-resistant antibodies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Candidate antibody-based therapeutics against HIV-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Shortened engineered human antibody CH2 domains: increased stability and binding to the human neonatal Fc receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Enhanced antibody half-life improves in vivo activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Engineered CH2 domains (nanoantibodies).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Targeting a homogeneously glycosylated antibody Fc to bind cancer cells using a synthetic receptor ligand
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
A large library based on a novel (CH2) scaffold: identification of HIV-1 inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Strategies to extend plasma half-lives of recombinant antibodies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
CD20-directed small modular immunopharmaceutical, TRU-015, depletes normal and malignant B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Engineered human antibody constant domains with increased stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Structure of an isolated unglycosylated antibody CH2 domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
An engineered selenocysteine defines a unique class of antibody derivatives
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcgammaRIIb with Fc-engineered antibodies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Single-domain antibodies as building blocks for novel therapeutics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Molecular engineering and design of therapeutic antibodies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Antibody therapeutics: isotype and glycoform selection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
FcRn: the neonatal Fc receptor comes of age.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Engineering antibodies for clinical applications
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Potent antibody therapeutics by design
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Engineered antibody Fc variants with enhanced effector function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Folding mechanism of the CH2 antibody domain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Domain antibodies: proteins for therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
An Fc receptor structurally related to MHC class I antigens
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
6 July 2018
Marketed therapeutic antibodies compendium
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
28 October 2018
Development trends for therapeutic antibody fragments
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
28 October 2018
Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
28 October 2018
High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4185235
retrieved
28 October 2018
Identifiers
DOI
10.1016/J.BBAPAP.2014.04.018
1 reference
stated in
Europe PubMed Central
PMC publication ID
4185235
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24792384%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
PMC publication ID
4185235
1 reference
stated in
Europe PubMed Central
PMC publication ID
4185235
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24792384%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
PubMed publication ID
24792384
1 reference
stated in
Europe PubMed Central
PMC publication ID
4185235
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24792384%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
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