(Q34293997)

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O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation

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scholarly article

1 reference

Europe PubMed Central

1 August 2017

O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation (English)

1 reference

Europe PubMed Central

1 August 2017

Douglas A. Lauffenburger

4

object named as

Douglas A Lauffenburger

1 reference

Europe PubMed Central

1 August 2017

author name string

Ericka M Noonan

1

1 reference

Europe PubMed Central

1 August 2017

Dharini Shah

2

1 reference

Europe PubMed Central

1 August 2017

Michael B Yaffe

3

1 reference

Europe PubMed Central

1 August 2017

Leona D Samson

5

1 reference

Europe PubMed Central

1 August 2017

publication date

1 October 2012

1 reference

Europe PubMed Central

1 August 2017

Integrative Biology

1 reference

Europe PubMed Central

1 August 2017

4

1 reference

Europe PubMed Central

1 August 2017

10

1 reference

Europe PubMed Central

1 August 2017

1237-1255

1 reference

Europe PubMed Central

1 August 2017

ATR signalling: more than meeting at the fork

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

ATM activation by oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

The DNA Damage Response: Making It Safe to Play with Knives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Multiple roles of ATM in monitoring and maintaining DNA integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

The DNA-damage response in human biology and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Blinded by the Light: The Growing Complexity of p53

1 reference

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6 July 2018

O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

JNK signaling in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

ATR: an essential regulator of genome integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Interplay of DNA repair pathways controls methylation damage toxicity in Saccharomyces cerevisiae

1 reference

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6 July 2018

The DNA damage response: ten years after

1 reference

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6 July 2018

Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Structure of the human MutSalpha DNA lesion recognition complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Homologous recombination prevents methylation-induced toxicity in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

GenePattern 2.0

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Characterization of the mismatch repair defect in the human lymphoblastoid MT1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Alkylation damage in DNA and RNA--repair mechanisms and medical significance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

MGMT: its role in cancer aetiology and cancer therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Chk1 and Chk2 kinases in checkpoint control and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

The mismatch repair system is required for S-phase checkpoint activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Genome maintenance mechanisms for preventing cancer

1 reference

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6 July 2018

The DNA damage response: putting checkpoints in perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Repair of O(6)-alkylguanine by alkyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Transcription factor ATF2 regulation by the JNK signal transduction pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

6 July 2018

Mechanisms of tolerance to DNA damaging therapeutic drugs

1 reference

https://api.crossref.org/works/10.1039%2FC2IB20091K

21 January 2018

Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting.

1 reference

https://api.crossref.org/works/10.1039%2FC2IB20091K

21 January 2018

Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts

1 reference

https://api.crossref.org/works/10.1039%2FC2IB20091K

21 January 2018

Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs

1 reference

https://api.crossref.org/works/10.1039%2FC2IB20091K

21 January 2018

DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

28 October 2018

Mutation in the magnesium binding site of hMSH6 disables the hMutSalpha sliding clamp from translocating along DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3574819

28 October 2018

A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22892544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrachromosomal probes for mutagenesis by alkylated DNA bases replicated in mammalian cells: a comparison of the mutagenicities of O4-methylthymine and O6-methylguanine in cells with different DNA repair backgrounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/22892544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

1 reference

https://pubmed.ncbi.nlm.nih.gov/22892544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O6-alkylguanine DNA lesions trigger apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22892544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Context-dependent mutagenesis by DNA lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22892544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1039/C2IB20091K

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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