(Q34301507)

1 August 2017

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title

Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease (English)

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1 August 2017

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2

Mark R Cookson

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1 August 2017

3

David W Miller

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1 August 2017

Melisa J Baptista

1

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1 August 2017

publication date

1 February 2004

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1 August 2017

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1 August 2017

volume

10

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1 August 2017

issue

1

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1 August 2017

page(s)

63-72

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

1 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

The septin CDCrel-1 binds syntaxin and inhibits exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Howard Henry Tooth (1856-1925)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Parkin's substrates and the pathways leading to neuronal damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

21 January 2018

Genetics of parkinsonism

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

alpha-Synuclein affects the MAPK pathway and accelerates cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Progression of nigrostriatal dysfunction in a parkin kindred: an [18F]dopa PET and clinical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

The septin CDCrel-1 is dispensable for normal development and neurotransmitter release

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Cytotoxic and genotoxic potential of dopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Toxic proteins in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Attenuation of dopamine transporter activity by alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858403260392

21 January 2018

Identifiers

DOI

10.1177/1073858403260392

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1 August 2017

1 reference