(Q34313778)

English

Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer

scientific article

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

object named as

Ajit Jadhav

10

0 references

9

object named as

Anton Simeonov

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

author name string

Thomas S Dexheimer

1

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Andrew S Rosenthal

2

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Diane K Luci

3

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Qin Liang

4

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Mark A Villamil

5

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Junjun Chen

6

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Hongmao Sun

7

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Edward H Kerns

8

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Zhihao Zhuang

11

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

David J Maloney

12

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

language of work or name

0 references

publication date

17 September 2014

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

57

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

19

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

8099-8110

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4191588/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

The ID proteins: master regulators of cancer stem cells and tumour aggressiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Using deuterium in drug discovery: leaving the label in the drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Synthesis and pharmacology of proteasome inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Deubiquitinating enzymes as therapeutic targets in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

The ubiquitin code

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Dialkylbiaryl Phosphines in Pd-Catalyzed Amination: A User's Guide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

The USP1/UAF1 complex promotes double-strand break repair through homologous recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Breaking the chains: structure and function of the deubiquitinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

DUBs and cancer: the role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Principles of ubiquitin and SUMO modifications in DNA repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Enantioselective intramolecular openings of oxetanes catalyzed by (salen)Co(III) complexes: access to enantioenriched tetrahydrofurans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Biaryl Phosphane Ligands in Palladium-Catalyzed Amination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Emerging roles of deubiquitinating enzymes in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Proteasome-independent functions of ubiquitin in endocytosis and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Ubiquitin ligases: cell-cycle control and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Regulation of monoubiquitinated PCNA by DUB autocleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Emerging roles of ubiquitin in transcription regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Mechanisms underlying ubiquitination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

6 July 2018

Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191588

28 October 2018

Efficient conversion of aromatic amines into azides: a one-pot synthesis of triazole linkages

1 reference

https://pubmed.ncbi.nlm.nih.gov/25229643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of chemokine receptor CCR4 antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/25229643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM5010495

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

release_3j2vxzispfgwbghe4beytfaq2q

1 reference

https://api.fatcat.wiki/v0/release/3j2vxzispfgwbghe4beytfaq2q

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34313778&oldid=1982356846"