(Q34322404)

1 August 2017

title

Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane (English)

1 reference

1 August 2017

author

Srinivasan Ramachandran

object named as

Srinivasan Ramachandran

series ordinal

4

0 references

Fernando Teran Arce

object named as

Fernando Teran Arce

series ordinal

3

0 references

Ruth Nussinov

series ordinal

7

object named as

Ruth Nussinov

1 reference

1 August 2017

1

Hyunbum Jang

1 reference

1 August 2017

5

Bruce L Kagan

1 reference

1 August 2017

6

Ratnesh Lal

1 reference

1 August 2017

2

Laura Connelly

1 reference

1 August 2017

publication date

5 December 2012

1 reference

Journal of Chemical Theory and Computation

1 August 2017

published in

1 reference

1 August 2017

volume

9

1 reference

1 August 2017

issue

1

1 reference

1 August 2017

page(s)

822-833

1 reference

Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicity

1 August 2017

cites work

1 reference

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6 July 2018

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6 July 2018

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Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity

6 July 2018

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All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers

6 July 2018

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Aberrant action of amyloidogenic host defense peptides: a new paradigm to investigate neurodegenerative disorders?

6 July 2018

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Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions

6 July 2018

1 reference

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Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology

6 July 2018

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Antimicrobial properties of amyloid peptides

6 July 2018

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Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation

6 July 2018

1 reference

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A partially folded structure of amyloid-beta(1-40) in an aqueous environment

6 July 2018

1 reference

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Membrane and surface interactions of Alzheimer's Aβ peptide--insights into the mechanism of cytotoxicity

6 July 2018

1 reference

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Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link

6 July 2018

1 reference

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β-Barrel topology of Alzheimer's β-amyloid ion channels

6 July 2018

1 reference

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Transmembrane structures for Alzheimer's Aβ(1-42) oligomers.

6 July 2018

1 reference

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Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

6 July 2018

1 reference

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Amyloid peptide pores and the beta sheet conformation.

6 July 2018

1 reference

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Structural convergence among diverse, toxic beta-sheet ion channels

6 July 2018

1 reference

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A molecular dynamics study of the early stages of amyloid-beta(1-42) oligomerization: the role of lipid membranes

6 July 2018

1 reference

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Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studies

6 July 2018

1 reference

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Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

6 July 2018

1 reference

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The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide

6 July 2018

1 reference

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Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Models of toxic beta-sheet channels of protegrin-1 suggest a common subunit organization motif shared with toxic alzheimer beta-amyloid ion channels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Stabilization of a -hairpin in monomeric Alzheimer's amyloid- peptide inhibits amyloid formation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

New structures help the modeling of toxic amyloidbeta ion channels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Modeling the Alzheimer Abeta17-42 fibril architecture: tight intermolecular sheet-sheet association and intramolecular hydrated cavities

6 July 2018

1 reference

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Models of beta-amyloid ion channels in the membrane suggest that channel formation in the bilayer is a dynamic process

6 July 2018

1 reference

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Conformational study of the protegrin-1 (PG-1) dimer interaction with lipid bilayers and its effect

6 July 2018

1 reference

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A beta oligomers - a decade of discovery

6 July 2018

1 reference

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Interaction of protegrin-1 with lipid bilayers: membrane thinning effect

6 July 2018

1 reference

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Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

6 July 2018

1 reference

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3D structure of Alzheimer's amyloid-beta(1-42) fibrils

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Scalable molecular dynamics with NAMD

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Amyloid ion channels: a common structural link for protein-misfolding disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

6 July 2018

Amyloid peptide channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Modeling amyloid beta-peptide insertion into lipid bilayers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

An Implicit Membrane Generalized Born Theory for the Study of Structure, Stability, and Interactions of Membrane Proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

The Effect of Cholesterol on the Lateral Diffusion of Phospholipids in Oriented Bilayers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Interactions of the designed antimicrobial peptide MB21 and truncated dermaseptin S3 with lipid bilayers: molecular-dynamics simulations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

A host-guest system to study structure-function relationships of membrane fusion peptides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Zn2+ interaction with Alzheimer amyloid beta protein calcium channels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

The infrared dichroism of transmembrane helical polypeptides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Amyloid β peptides aggregation in a mixed membrane bilayer: a molecular dynamics study.

28 October 2018

1 reference

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A new structural model of Aβ40 fibrils.

28 October 2018

1 reference

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Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.

28 October 2018

1 reference

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Molecular dynamics simulations of the influenza hemagglutinin fusion peptide in micelles and bilayers: conformational analysis of peptide and lipids

28 October 2018

1 reference

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Generalized born model with a simple smoothing function.

28 October 2018

1 reference

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Diversity of amyloid beta protein fragment [1-40]-formed channels.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

Molecular Interactions of Alzheimer's Aβ Protofilaments with Lipid Membranes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3539805

An ab Initio Study on the Torsional Surface of Alkanes and Its Effect on Molecular Simulations of Alkanes and a DPPC Bilayer

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23316126

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structure of the amyloid-beta (1-42) monomer absorbed to model phospholipid bilayers: a molecular dynamics study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23316126

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/CT300916F

1 reference

1 August 2017

1 reference

1 August 2017

1 reference