(Q34324177)

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Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor.

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22 February 2020

Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor (English)

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22 February 2020

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Saskia Nijmeijer

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22 February 2020

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22 February 2020

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H Engelhardt

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22 February 2020

S Schultes

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22 February 2020

A C van de Stolpe

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22 February 2020

V Lusink

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22 February 2020

M Wijtmans

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22 February 2020

E E J Haaksma

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22 February 2020

I J P de Esch

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22 February 2020

K Stachurski

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22 February 2020

H F Vischer

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22 February 2020

R Leurs

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22 February 2020

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1 September 2013

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22 February 2020

British Journal of Pharmacology

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22 February 2020

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22 February 2020

1

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22 February 2020

89-100

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22 February 2020

Analysis of multiple histamine H₄ receptor compound classes uncovers Gαi protein- and β-arrestin2-biased ligands

1 reference

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Molecular determinants of selective agonist and antagonist binding to the histamine H₄ receptor

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Agonist-biased signaling at the histamine H4 receptor: JNJ7777120 recruits β-arrestin without activating G proteins.

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A new generation of anti-histamines: Histamine H4 receptor antagonists on their way to the clinic

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1 reference

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Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations

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Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics

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12 December 2020

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10.1111/BPH.12113

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Europe PubMed Central

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22 February 2020

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22 February 2020

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22 February 2020

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