(Q34324403)

1 August 2017

title

Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4. (English)

1 reference

1 August 2017

6

Tom Misteli

1 reference

1 August 2017

5

Sushil Rane

1 reference

1 August 2017

Patricia Fernandez

1

1 reference

1 August 2017

Paola Scaffidi

series ordinal

2

1 reference

1 August 2017

Elke Markert

series ordinal

3

1 reference

1 August 2017

Ji-Hyeon Lee

series ordinal

4

1 reference

1 August 2017

publication date

2 October 2014

1 reference

1 August 2017

1 reference

1 August 2017

volume

9

1 reference

1 August 2017

issue

1

1 reference

1 August 2017

page(s)

248-260

1 reference

describes a project that uses

1 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4194066/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer

6 July 2018

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Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.

6 July 2018

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6 July 2018

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The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Function of oncogenes in cancer development: a changing paradigm

6 July 2018

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Selective inhibition of tumor oncogenes by disruption of super-enhancers

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting

6 July 2018

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Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

6 July 2018

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6 July 2018

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Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

6 July 2018

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BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia

6 July 2018

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Cancer epigenetics: from mechanism to therapy

6 July 2018

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Aberrant epigenetic regulation of bromodomain BRD4 in human colon cancer.

6 July 2018

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Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation

6 July 2018

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

6 July 2018

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

6 July 2018

1 reference

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

In vitro generation of human cells with cancer stem cell properties

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Deletion of the proline-rich region of the murine metastasis susceptibility gene Brd4 promotes epithelial-to-mesenchymal transition- and stem cell-like conversion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Suppression of inflammation by a synthetic histone mimic

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

TGFbeta signalling: a complex web in cancer progression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

DNA Damage, Aging, and Cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Bromodomain 4 activation predicts breast cancer survival

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Human premature aging, DNA repair and RecQ helicases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Lamin A-dependent nuclear defects in human aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

The cell nucleus and aging: tantalizing clues and hopeful promises

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Lamin a truncation in Hutchinson-Gilford progeria.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Cancer susceptibility and the functions of BRCA1 and BRCA2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Gene expression profiling predicts clinical outcome of breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

6 July 2018

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Creation of human tumour cells with defined genetic elements

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Cells of the cellular immune and hemopoietic system of the mouse lack lamins A/C: distinction versus other somatic cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Progeria: a paradigm for translational medicine.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4194066

Nuclear matrix proteins specific for subtypes of human hematopoietic cells

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25284786

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25284786

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2014.08.069

1 reference

1 August 2017

1 reference

1 August 2017

1 reference