(Q34328370)

1 August 2017

title

The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. (English)

1 reference

1 August 2017

2

Alexandra C Newton

1 reference

1 August 2017

Charles C King

1

1 reference

1 August 2017

language of work or name

English

0 references

publication date

21 June 2004

1 reference

Journal of Biological Chemistry

1 August 2017

published in

1 reference

1 August 2017

volume

279

1 reference

1 August 2017

issue

36

1 reference

1 August 2017

page(s)

37518-37527

1 reference

Three protein kinase structures define a common motif

1 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Cellular signaling: pivoting around PDK-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

The PI3K-PDK1 connection: more than just a road to PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Intracellular signalling: PDK1--a kinase at the hub of things

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Interactions between mitogenic stimuli, or, a thousand and one connections

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

PDK1, one of the missing links in insulin signal transduction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Cloning and characterization of GRB14, a novel member of the GRB7 gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Identification of the rat adapter Grb14 as an inhibitor of insulin actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Role for the adaptor protein Grb10 in the activation of Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405340200

21 January 2018

Identifiers

DOI

10.1074/JBC.M405340200

1 reference

1 August 2017

1 reference