(Q34353458)

1 August 2017

Opportunities and challenges of pluripotent stem cell neurodegenerative disease models (English)

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1 August 2017

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2

Kevin Eggan

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1 August 2017

Jackson Sandoe

1

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PubMed ID

23799470

1 August 2017

language of work or name

English

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publication date

25 June 2013

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1 August 2017

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16

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7

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1 August 2017

780-789

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https://scigraph.springernature.com/pub.10.1038/nn.3425

1 August 2017

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cites work

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Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

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12 December 2020

Autophagy gone awry in neurodegenerative diseases

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A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

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12 December 2020

Neuroprotective and neurorestorative strategies for Parkinson's disease

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12 December 2020

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

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12 December 2020

Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression

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12 December 2020

Investigating synapse formation and function using human pluripotent stem cell-derived neurons

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Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

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12 December 2020

Directed differentiation of embryonic stem cells into motor neurons

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12 December 2020

Genetic engineering of human pluripotent cells using TALE nucleases

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12 December 2020

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

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12 December 2020

Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells

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12 December 2020

Erosion of dosage compensation impacts human iPSC disease modeling

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12 December 2020

Accelerated high-yield generation of limb-innervating motor neurons from human stem cells

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12 December 2020

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis

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12 December 2020

Induced pluripotent stem cells from a spinal muscular atrophy patient

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12 December 2020

Neuronal subtype specification in the cerebral cortex

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12 December 2020

Fluorescent activated cell sorting (FACS): a rapid and reliable method to estimate the number of neurons in a mixed population

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12 December 2020

Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity

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Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

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12 December 2020

Embryonic stem cell lines derived from human blastocysts

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12 December 2020

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

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12 December 2020

Pitx3 is required for development of substantia nigra dopaminergic neurons.

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12 December 2020

Induction of human neuronal cells by defined transcription factors

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12 December 2020

Protein folding stress in neurodegenerative diseases: a glimpse into the ER.

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12 December 2020

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

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12 December 2020

Constructing and deconstructing stem cell models of neurological disease

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12 December 2020

Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors

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12 December 2020

Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation

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12 December 2020

Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells

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12 December 2020

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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12 December 2020

A functionally characterized test set of human induced pluripotent stem cells

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12 December 2020

Genome editing with engineered zinc finger nucleases

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12 December 2020

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

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12 December 2020

LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease

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12 December 2020

Broader Implications of Defining Standards for the Pluripotency of iPSCs

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12 December 2020

Maturation of spinal motor neurons derived from human embryonic stem cells

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12 December 2020

X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells

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12 December 2020

Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy

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12 December 2020

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

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12 December 2020

Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells

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12 December 2020

Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells

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12 December 2020

Early frontotemporal dementia targets neurons unique to apes and humans

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12 December 2020

Marked differences in differentiation propensity among human embryonic stem cell lines

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12 December 2020

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

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12 December 2020

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

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12 December 2020

Induced pluripotent stem cell lines derived from human somatic cells

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12 December 2020

Derivation of human embryonic stem cell lines from embryos obtained after IVF and after PGD for monogenic disorders.

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12 December 2020

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

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12 December 2020

Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines

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12 December 2020

Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells

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12 December 2020

Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation.

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12 December 2020

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease

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12 December 2020

A human stem cell model of early Alzheimer's disease pathology in Down syndrome

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12 December 2020

Selective cell death in neurodegeneration: why are some neurons spared in vulnerable regions?

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12 December 2020

Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes.

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12 December 2020

Mechanisms underlying targeted gene correction using chimeric RNA/DNA and single-stranded DNA oligonucleotides

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12 December 2020

Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development

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12 December 2020

A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells

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12 December 2020

A TALEN genome-editing system for generating human stem cell-based disease models

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12 December 2020

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex

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12 December 2020

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

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12 December 2020

Human embryonic stem cell lines with genetic disorders

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12 December 2020

Conversion of mouse and human fibroblasts into functional spinal motor neurons

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12 December 2020

A bioinformatic assay for pluripotency in human cells

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12 December 2020

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

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12 December 2020

MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors

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12 December 2020

Modelling schizophrenia using human induced pluripotent stem cells

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12 December 2020

AAV-mediated gene targeting methods for human cells

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12 December 2020

Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells

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12 December 2020

Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

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12 December 2020

In vitro differentiation of transplantable neural precursors from human embryonic stem cells

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12 December 2020

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

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12 December 2020

Drug screening for ALS using patient-specific induced pluripotent stem cells

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12 December 2020

Induced pluripotent stem cells: the new patient?

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12 December 2020

The homeodomain transcription factors Islet 1 and HB9 are expressed in adult alpha and gamma motoneurons identified by selective retrograde tracing

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12 December 2020

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

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12 December 2020

Molecular aging in human prefrontal cortex is selective and continuous throughout adult life.

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12 December 2020

Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient.

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12 December 2020

RNA-guided human genome engineering via Cas9

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12 December 2020

Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures

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12 December 2020

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

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12 December 2020

Site-specific integration and tailoring of cassette design for sustainable gene transfer.

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12 December 2020

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.

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12 December 2020

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

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12 December 2020

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease

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12 December 2020

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

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12 December 2020

Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures

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12 December 2020

Transcriptional signature and memory retention of human-induced pluripotent stem cells

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12 December 2020

Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells

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12 December 2020

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

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12 December 2020

Feeder-free growth of undifferentiated human embryonic stem cells

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12 December 2020

Motor neuron diversity in development and disease

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12 December 2020

Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes

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12 December 2020

Progress toward the clinical application of patient-specific pluripotent stem cells

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12 December 2020

A small molecule-kinase interaction map for clinical kinase inhibitors

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12 December 2020

Disease-specific induced pluripotent stem cells

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12 December 2020

Identifiers

DOI

10.1038/NN.3425

1 reference

PubMed ID

23799470

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

23799470