(Q34361796)

1 August 2017

title

Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids (English)

1 reference

1 August 2017

Nicolas Boyer

1

1 reference

1 August 2017

Karen C Morrison

2

1 reference

1 August 2017

Justin Kim

3

1 reference

1 August 2017

Paul J Hergenrother

4

1 reference

1 August 2017

Mohammad Movassaghi

5

1 reference

1 August 2017

publication date

1 April 2013

1 reference

1 August 2017

1 reference

1 August 2017

volume

4

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1 August 2017

issue

4

1 reference

1 August 2017

page(s)

1646-1657

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Antibody-drug conjugates for the treatment of cancer

1 August 2017

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6 July 2018

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6 July 2018

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6 July 2018

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Inhibition of hypoxia-inducible transcription factor complex with designed epipolythiodiketopiperazine

6 July 2018

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General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A and C and (+)-12,12′-Dideoxychetracin A

6 July 2018

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Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity

6 July 2018

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Enantioselective organocatalytic alpha-sulfenylation of substituted diketopiperazines

6 July 2018

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Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine

6 July 2018

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Ecology-based screen identifies new metabolites from a Cordyceps-colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducers

6 July 2018

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Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

Total synthesis of (+)-11,11'-dideoxyverticillin A

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

Apoptosis and necrosis: detection, discrimination and phagocytosis

6 July 2018

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6 July 2018

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Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes

6 July 2018

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Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress

6 July 2018

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Selective inactivation of glutaredoxin by sporidesmin and other epidithiopiperazinediones

6 July 2018

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Leptosins isolated from marine fungus Leptoshaeria species inhibit DNA topoisomerases I and/or II and induce apoptosis by inactivation of Akt/protein kinase B.

6 July 2018

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The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis

6 July 2018

1 reference

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Fungal metabolite gliotoxin targets flavocytochrome b558 in the activation of the human neutrophil NADPH oxidase

6 July 2018

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Scabrosin esters and derivatives: chemical derivatization studies and biological evaluation

6 July 2018

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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

6 July 2018

1 reference

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Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo.

6 July 2018

1 reference

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A novel redox mechanism for the glutathione-dependent reversible uptake of a fungal toxin in cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

Formation and transfer of disulphide bonds in living cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

Redox sensitive epidithiodioxopiperazines in biological mechanisms of toxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

Gliotoxin and related epipolythiodioxopiperazines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

6 July 2018

1 reference

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A total synthesis of sporidesmin A.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

A total synthesis of dehydrogliotoxin.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

Antiviral agents. Chemical modifications of a disulfide antibiotic, acetylaranotin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

Structural relationship of epipolythiodioxopiperazines and their immunomodulating activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

Approaches to analogues of dehydrogliotoxin. 6. An efficient synthesis of a gliotoxin analogue with anti-reverse transcriptase activity

6 July 2018

1 reference

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A total synthesis of gliotoxin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728915

Diketopiperazines from marine organisms.

6 July 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3SC50174D

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

21 January 2018

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Specific inhibition of viral ribonucleic acid replication by Gliotoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3SC50174D

Gliotoxin as putative virulence factor and immunotherapeutic target in a cell culture model of cerebral aspergillosis.

21 January 2018

1 reference

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Nematicidal epipolysulfanyldioxopiperazines from Gliocladium roseum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3SC50174D

Candida albicans and its metabolite gliotoxin inhibit platelet function via interaction with thiols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3SC50174D

Dirhodium(II) tetraacetate catalysed reactions of diazo thioamides: isolation and cycloaddition of anhydro-4-hydroxy-1,3-thiazolium hydroxides (thioisomünchnones), an approach to analogues of dehydrogliotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3SC50174D

Construction of epidithiodioxopiperazines by directed oxidation of hydroxyproline-derived dioxopiperazines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3SC50174D

The involvement of the disulphide group of sporidesmin in the action of the toxin on swelling and respiration of liver mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3SC50174D

Novel cytotoxic thiodiketopiperazine derivatives from a Tilachlidium sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3SC50174D

Gliotoxin inactivates alcohol dehydrogenase by either covalent modification or free radical damage mediated by redox cycling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3SC50174D

Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3SC50174D

Mild aerobic oxidative palladium (II) catalyzed C-H bond functionalization: regioselective and switchable C-H alkenylation and annulation of pyrroles

21 January 2018

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Total Synthesis of 5-N-Acetylardeemin and Amauromine: Practical Routes to Potential MDR Reversal Agents

21 January 2018

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The promise of antibody-drug conjugates.

21 January 2018

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Cytotoxic metabolites from the antarctic psychrophilic fungus Oidiodendron truncatum

21 January 2018

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Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells.

27 October 2018

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DNA synthesis precedes gliotoxin-induced apoptosis

27 October 2018

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Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines

27 October 2018

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https://api.crossref.org/works/10.1039%2FC3SC50174D

Minor phytotoxins from the blackleg fungus Phoma lingam

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3SC50174D

Isolation of the first naturally occurring epimonothiodioxopiperazine, a fungal toxin produced by phoma lingam

21 January 2018

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Antiviral Activity of Gliotoxin and Gliotoxin Acetate

21 January 2018

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[Studies in the synthesis of the antibiotics Gliotoxin, sporidesmin, Aranotin, and chaetocin. 3. Introduction of alkyl groups and sulfur functions into the 3- and 6-positions of 2.5-dioxopiperazines by electrophilic substitutions]

21 January 2018

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12 December 2020

Bionectins A−C, Epidithiodioxopiperazines with Anti-MRSA Activity, fromBionectra byssicolaF120

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12 December 2020

On the Determination of the Stereochemistry of Semisynthetic Natural Product Analogues using Chiroptical Spectroscopy: Desulfurization of Epidithiodioxopiperazine Fungal Metabolites

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12 December 2020

Studies on the mechanism of toxicity of the mycotoxin, sporidesmin. V. Generation of hydroxyl radical by sporidesmin

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12 December 2020

Effects of gliotoxin and other sulfur-containing compounds on tumor cells in vitro; with observations on the mechanism of action of gliotoxin

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12 December 2020

Thiolation of symmetrical and unsymmetrical diketopiperazines

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12 December 2020

Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures

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12 December 2020

Inactivation of rabbit muscle creatine kinase by reversible formation of an internal disulfide bond induced by the fungal toxin gliotoxin

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12 December 2020

Antiviral activity of N,N′-dimethyl-epidithiapiperazinedione, a synthetic compound related to the gliotoxins, LL-S88α and β, chetomin and the sporidesmins

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12 December 2020

A short synthesis of aromatic analogues of the aranotins

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12 December 2020

Mercaptoacyl dipeptides as orally active dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase

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12 December 2020

[Amino acids and peptides. VII. Studies on the synthesis of 3,6-epidithio-2,5-dioxopiperazine antibiotics: gliotoxin, sporidesmin, aranotin, chaetocin, and verticillin. VII. The introduction of oxygen into prolyl-prolinanhydride via lead acetate: a

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12 December 2020

Synthesis and biological activities of chaetocin and its derivatives

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20 August 2023

https://opencitations.net/index/coci/api/v1/citations/10.1351/PAC-CON-11-10-31

Gliocladins A - C and Glioperazine ; Cytotoxic Dioxo- or Trioxopiperazine Metabolites from a Gliocladium Sp. Separated from a Sea Hare

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.3987/COM-04-10037

Leptosins O-S, Cytotoxic Metabolites of a Strain of Leptosphaeria Sp. Isolated from a Marine Alga

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.3987/COM-03-9967

Chetracin A and chaetocins B and C, three new epipolythiodioxopiperazines from Chaetomium spp.

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.1248/CPB.36.1942

Identifiers

DOI

10.1039/C3SC50174D

1 reference

1 August 2017

1 reference

1 August 2017

1 reference