(Q34362828)

1 August 2017

O6-methylguanine-DNA methyltransferase in the defense against N-nitroso compounds and colorectal cancer (English)

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1 August 2017

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Jörg Fahrer

1

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PubMed ID

23929436

1 August 2017

Bernd Kaina

series ordinal

2

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PubMed ID

23929436

1 August 2017

language of work or name

English

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publication date

8 August 2013

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1 August 2017

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1 August 2017

34

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1 August 2017

11

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1 August 2017

2435-2442

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

1 August 2017

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Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Intestinal inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Looking for causes of neural tube defects: where does the environment fit in?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Colon cancer: a civilization disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Nutrition and dietary carcinogens

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

N-Nitroso compounds in the diet

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Determination of N-nitrosodiethanolamine in cosmetic products by LC-MS-MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Progress and challenges in selected areas of tobacco carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Genotoxicity of streptozotocin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Biology of nitrogen oxides in the gastrointestinal tract

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer?

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

The effect of haem in red and processed meat on the endogenous formation of N-nitroso compounds in the upper gastrointestinal tract.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Why do O6-alkylguanine and O4-alkylthymine miscode? The relationship between the structure of DNA containing O6-alkylguanine and O4-alkylthymine and the mutagenic properties of these bases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Red meat enhances the colonic formation of the DNA adduct O6-carboxymethyl guanine: implications for colorectal cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Cloning and characterization of a mouse 3-methyladenine/7-methyl-guanine/3-methylguanine DNA glycosylase cDNA whose gene maps to chromosome 11

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Mechanisms of human DNA repair: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Reversal of DNA alkylation damage by two human dioxygenases

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

DNA repair is indispensable for survival after acute inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

O(6)-methylguanine-DNA methyltransferase (MGMT): impact on cancer risk in response to tobacco smoke

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

The cytotoxicity of DNA carboxymethylation and methylation by the model carboxymethylating agent azaserine in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Detection of O6-carboxymethyl-2'-deoxyguanosine in DNA following reaction of nitric oxide with glycine and in human blood DNA using a quantitative immunoslot blot assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Potassium diazoacetate-induced p53 mutations in vitro in relation to formation of O6-carboxymethyl- and O6-methyl-2'-deoxyguanosine DNA adducts: relevance for gastrointestinal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

DNA repair protein MGMT protects against N-methyl-N-nitrosourea-induced conversion of benign into malignant tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

A novel inflammation‐related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Chemically induced mouse models of intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Elevated levels of the pro-carcinogenic adduct, O(6)-methylguanine, in normal DNA from the cancer prone regions of the large bowel

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Heterogeneity of O(6)-alkylguanine-DNA alkyltransferase activity in colorectal cancer: implications for treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

The promoter methylation status of the DNA repair gene O6-methylguanine-DNA methyltransferase in ulcerative colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

CpG island methylation in aberrant crypt foci of the colorectum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Reduced MGMT activity in human colorectal adenomas is associated with K-ras GC->AT transition mutations in a population exposed to methylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

MGMT promoter methylation and field defect in sporadic colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane-induced colon carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Chemopreventive effect of dietary glutamine on colitis-associated colon tumorigenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver--comparison with phase II xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Molecular origins of cancer: Molecular basis of colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Targeting O⁶-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Response to temozolomide in patients with metastatic colorectal cancer with loss of MGMT expression: a new approach in the era of personalized medicine?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical response to dacarbazine in a phase II study for metastatic colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

A genetic model for colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGT275

21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGT275

1 reference

1 August 2017

1 reference

PubMed ID

23929436