(Q34379841)

1 August 2017

title

Topology of mammalian developmental enhancers and their regulatory landscapes (English)

1 reference

1 August 2017

2

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Wouter de Laat

object named as

Wouter de Laat

series ordinal

1

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language of work or name

English

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publication date

1 October 2013

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1 August 2017

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1 August 2017

volume

502

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1 August 2017

issue

7472

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1 August 2017

page(s)

499-506

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Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1 August 2017

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In vivo enhancer analysis of human conserved non-coding sequences

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Tissue-specific transcriptional regulation has diverged significantly between human and mouse

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Species-specific transcription in mice carrying human chromosome 21

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Integration of ChIP-seq and machine learning reveals enhancers and a predictive regulatory sequence vocabulary in melanocytes

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Maintenance of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription

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Variegated gene expression caused by cell-specific long-range DNA interactions

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A switch between topological domains underlies HoxD genes collinearity in mouse limbs

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The beta-globin nuclear compartment in development and erythroid differentiation

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Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression

21 January 2018

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The active spatial organization of the beta-globin locus requires the transcription factor EKLF

21 January 2018

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Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.

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Robust 4C-seq data analysis to screen for regulatory DNA interactions.

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Sonic hedgehog mediates the polarizing activity of the ZPA

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A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

21 January 2018

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Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb.

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Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription.

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Topological domains in mammalian genomes identified by analysis of chromatin interactions

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Opposing functions of the ETS factor family define Shh spatial expression in limb buds and underlie polydactyly

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Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling

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eRNAs are required for p53-dependent enhancer activity and gene transcription

21 January 2018

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The long-range interaction landscape of gene promoters

21 January 2018

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Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation

21 January 2018

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CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus

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A regulatory archipelago controls Hox genes transcription in digits

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Flanking HS-62.5 and 3' HS1, and regions upstream of the LCR, are not required for beta-globin transcription

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Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region

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An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape.

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A global control region defines a chromosomal regulatory landscape containing the HoxD cluster

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Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression

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Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition

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Reshuffling genomic landscapes to study the regulatory evolution of Hox gene clusters

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A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter

21 January 2018

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Targeted deletion of 5'HS1 and 5'HS4 of the beta-globin locus control region reveals additive activity of the DNaseI hypersensitive sites

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Spatial partitioning of the regulatory landscape of the X-inactivation centre

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Three-dimensional folding and functional organization principles of the Drosophila genome

21 January 2018

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Comprehensive mapping of long-range interactions reveals folding principles of the human genome

21 January 2018

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Architectural protein subclasses shape 3D organization of genomes during lineage commitment

21 January 2018

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Interchromosomal association and gene regulation in trans

21 January 2018

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Evidence for a critical role of gene occlusion in cell fate restriction

21 January 2018

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A TALE nuclease architecture for efficient genome editing

21 January 2018

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

21 January 2018

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Cis-ruption mechanisms: disruption of cis-regulatory control as a cause of human genetic disease

21 January 2018

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Evolution and functional classification of vertebrate gene deserts

21 January 2018

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Deletion of ultraconserved elements yields viable mice

21 January 2018

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Segmental folding of chromosomes: a basis for structural and regulatory chromosomal neighborhoods?

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24153303

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Local and cis effects of the H element on expression of odorant receptor genes in mouse

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24153303

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

What does our genome encode?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24153303

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE12753

1 reference

Dimensions Publication ID

1 August 2017

1023475926

0 references

1 reference