(Q34387276)

1 August 2017

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title

The histamine H3 receptor: from gene cloning to H3 receptor drugs (English)

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1 August 2017

Rob Leurs

1

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1 August 2017

Remko A Bakker

series ordinal

2

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1 August 2017

Henk Timmerman

series ordinal

3

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1 August 2017

Iwan J P de Esch

series ordinal

4

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1 August 2017

publication date

1 February 2005

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Nature Reviews Drug Discovery

1 August 2017

published in

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1 August 2017

volume

4

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1 August 2017

issue

2

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1 August 2017

page(s)

107-120

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https://scigraph.springernature.com/pub.10.1038/nrd1631

1 August 2017

exact match

0 references

1 reference

Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

21 January 2018

1 reference

The role of histamine and the tuberomamillary nucleus in the nervous system

21 January 2018

1 reference

Expression analysis of the histamine H(3) receptor in developing rat tissues

21 January 2018

1 reference

A detailed autoradiographic mapping of histamine H3 receptors in rat brain areas.

21 January 2018

1 reference

H3 receptor gene is cloned at last

21 January 2018

1 reference

Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes

21 January 2018

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Molecular cloning and characterization of a new human histamine receptor, HH4R

21 January 2018

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Genetic and pharmacological aspects of histamine H3 receptor heterogeneity

21 January 2018

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Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations

21 January 2018

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Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H(3) receptor

21 January 2018

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Genomic organization and characterization of splice variants of the human histamine H3 receptor

21 January 2018

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High constitutive activity of native H3 receptors regulates histamine neurons in brain.

21 January 2018

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Molecular modeling and pharmacological analysis of species-related histamine H(3) receptor heterogeneity

21 January 2018

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Characteristics of recombinantly expressed rat and human histamine H3 receptors

21 January 2018

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The rat H3 receptor: gene organization and multiple isoforms.

21 January 2018

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Molecular and pharmacological characterization of the mouse histamine H3 receptor

21 January 2018

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Cloning and pharmacological characterization of the monkey histamine H3 receptor

21 January 2018

1 reference

21 January 2018

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Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms

21 January 2018

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Behavioral characterization of mice lacking histamine H(3) receptors.

21 January 2018

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Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP gamma[S] binding to pertussis toxin.

21 January 2018

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Histamine H3-receptor-mediated [35S]GTP gamma[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors.

21 January 2018

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Coupling of histamine H3 receptors to neuronal Na+/H+ exchange: a novel protective mechanism in myocardial ischemia

21 January 2018

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Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings

21 January 2018

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Glycogen synthase kinase-3beta is complexed with tau protein in brain microtubules

21 January 2018

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A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala

21 January 2018

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Presynaptic H3 autoreceptors modulate histamine synthesis through cAMP pathway.

21 January 2018

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The glamour and gloom of glycogen synthase kinase-3

21 January 2018

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Histamine H3 receptor agonists

21 January 2018

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Highly potent and selective ligands for histamine H3-receptors

21 January 2018

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Trans-4-methyl-3-imidazoyl pyrrolidine as a potent, highly selective histamine H3 receptor agonist in vivo

21 January 2018

1 reference

In vivo modulation of rat hypothalamic histamine release by the histamine H3 receptor ligands, immepip and clobenpropit. Effects of intrahypothalamic and peripheral application.

21 January 2018

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(R)-α-Methylhistamine augments neural, cholinergic bronchospasm in guinea pigs by histamine H1 receptor activation

21 January 2018

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Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist

21 January 2018

1 reference

Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity

21 January 2018

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Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain

21 January 2018

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Brain structures and mechanisms involved in the control of cortical activation and wakefulness, with emphasis on the posterior hypothalamus and histaminergic neurons

21 January 2018

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Activation of spinal histamine H3 receptors inhibits mechanical nociception

21 January 2018

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Increased severity of reperfusion arrhythmias in mouse hearts lacking histamine H3-receptors

21 January 2018

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Effect of an inhaled histamine H3-receptor agonist on airway responses to sodium metabisulphite in asthma

21 January 2018

1 reference

Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors

21 January 2018

1 reference

Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects

21 January 2018

1 reference

Protean agonism at histamine H3 receptors in vitro and in vivo

21 January 2018

1 reference

Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist

21 January 2018

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[125I]iodoproxyfan and related compounds: a reversible radioligand and novel classes of antagonists with high affinity and selectivity for the histamine H3 receptor.

21 January 2018

1 reference

General construction pattern of histamine H3-receptor antagonists: change of a paradigm

21 January 2018

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Design, synthesis, and structure-activity relationships of acetylene-based histamine H3 receptor antagonists

21 January 2018

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An efficient multigram synthesis of the potent histamine H3 antagonist GT-2331 and the reassessment of the absolute configuration

21 January 2018

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Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template

21 January 2018

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SLATE: a method for the superposition of flexible ligands.

21 January 2018

1 reference

Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine

21 January 2018

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H3 receptor antagonist, thioperamide, inhibits adrenal steroidogenesis and histamine binding to adrenocortical microsomes and binds to cytochrome P450

21 January 2018

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Coordination of histamine H3 receptor antagonists with human adrenal cytochrome P450 enzymes

21 January 2018

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A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans

21 January 2018

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The medicinal chemistry of novel H(3) antagonists

21 January 2018

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A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines

21 January 2018

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1-alkyl-4-acylpiperazines as a new class of imidazole-free histamine H(3) receptor antagonists

21 January 2018

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Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687).

21 January 2018

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Activation of histamine H3 receptors in human nasal mucosa inhibits sympathetic vasoconstriction

21 January 2018

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Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001

21 January 2018

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H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

21 January 2018

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Expression of the H3 receptor in the developing CNS and brown fat suggests novel roles for histamine

21 January 2018

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In vivo release of neuronal histamine in the hypothalamus of rats measured by microdialysis

21 January 2018

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Central H3R activation by thioperamide does not affect energy balance

21 January 2018

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In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists

21 January 2018

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The effects of antihistamines on cognition and performance

21 January 2018

1 reference

Roles of histamine in regulation of arousal and cognition: functional neuroimaging of histamine H1 receptors in human brain

21 January 2018

1 reference

Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization

21 January 2018

1 reference

Modafinil increases histamine release in the anterior hypothalamus of rats

21 January 2018

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Central histaminergic system and cognition

21 January 2018

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Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia.

21 January 2018

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Effects of thioperamide, a histamine H3 antagonist, on the step-through passive avoidance response and histidine decarboxylase activity in senescence-accelerated mice.

21 January 2018

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Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup.

21 January 2018

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Cognition enhancing effects of novel H(3) receptor (H(3)R) antagonists in several animal models

21 January 2018

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Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors

21 January 2018

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The two-state model of receptor activation

21 January 2018

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Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists

21 January 2018

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Inverse agonism and the regulation of receptor number

21 January 2018

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Genomics meets histamine receptors: new subtypes, new receptors.

21 January 2018

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Cloning and functional expression of the human histamine H3 receptor

31 March 2020

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Identification of rat H3 receptor isoforms with different brain expression and signaling properties.

31 March 2020

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Immunological identification of the mammalian H3 histamine receptor in the mouse brain

31 March 2020

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Molecular cloning of a gene encoding the histamine H2 receptor

31 March 2020

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Expression cloning of a cDNA encoding the bovine histamine H1 receptor

31 March 2020

1 reference

Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

Cloning, expression, and pharmacological characterization of a novel human histamine receptor.

1 reference

Discovery of a novel member of the histamine receptor family

31 March 2020

1 reference

Genomic organization and characterization of splice variants of the human histamine H3 receptor

31 March 2020

1 reference

Alternative splicing of the histamine H(3) receptor mRNA at the third cytoplasmic loop is not detectable in humans

31 March 2020

1 reference

Cloning and cerebral expression of the guinea pig histamine H3 receptor: evidence for two isoforms

31 March 2020

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Chromosomal mapping and organization of the human histamine H3 receptor gene.

31 March 2020

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Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype

31 March 2020

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Improvement in fear memory by histamine-elicited ERK2 activation in hippocampal CA3 cells.

31 March 2020

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Histamine H3 receptor activation inhibits glutamate release from rat striatal synaptosomes

31 March 2020

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Synthesis, X-ray crystallography, and pharmacokinetics of novel azomethine prodrugs of (R)-alpha-methylhistamine: highly potent and selective histamine H3 receptor agonists

31 March 2020

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Cardiovascular effects of selective agonists and antagonists of histamine H3 receptors in the anaesthetized rat

31 March 2020

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A new potent and selective histamine H3 receptor agonist, 4-(1H-imidazol-4-ylmethyl)piperidine

31 March 2020

1 reference

Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole

31 March 2020

1 reference

UK-14,304, R(−)-α-methyl-histamine and SMS 201-995 block plasma protein leakage within dura mater by prejunctional mechanisms

31 March 2020

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Histamine H3-receptors inhibit neurogenic microvascular leakage in airways

31 March 2020

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Nalpha-methylhistamine safety and efficacy in migraine prophylaxis: phase I and phase II studies

31 March 2020

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Synthesis and histamine H3 receptor activity of 4-(n-alkyl)-1H-imidazoles and 4-(omega-phenylalkyl)-1H-imidazoles

31 March 2020

1 reference

Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE.

31 March 2020

1 reference

Synthesis of potent non-imidazole histamine H3-receptor antagonists.

31 March 2020

1 reference

Piperidino-hydrocarbon compounds as novel non-imidazole histamine H(3)-receptor antagonists

31 March 2020

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Combined histamine H1 and H3 receptor blockade produces nasal decongestion in an experimental model of nasal congestion

31 March 2020

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Histaminergic modulation of hippocampal acetylcholine release in vivo.

31 March 2020

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Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

31 March 2020

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Agonist-independent regulation of constitutively active G-protein-coupled receptors

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1631

1 reference

1 August 2017

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