(Q34391068)

1 August 2017

title

Double-strand break repair: 53BP1 comes into focus (English)

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1 August 2017

Stephanie Panier

1

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1 August 2017

Simon J Boulton

series ordinal

2

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1 August 2017

publication date

11 December 2013

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Nature Reviews Molecular Cell Biology

1 August 2017

published in

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1 August 2017

volume

15

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1 August 2017

issue

1

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1 August 2017

page(s)

7-18

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Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid

1 August 2017

cites work

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Loss of a yeast telomere: arrest, recovery, and chromosome loss.

31 March 2020

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The DNA-damage response in human biology and disease

31 March 2020

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Two cellular proteins that bind to wild-type but not mutant p53

31 March 2020

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Tying the loose ends together in DNA double strand break repair with 53BP1.

31 March 2020

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Surviving the breakup: the DNA damage checkpoint.

31 March 2020

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Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1

31 March 2020

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Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint

31 March 2020

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Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage

31 March 2020

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Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation

31 March 2020

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Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

31 March 2020

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Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

31 March 2020

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53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

31 March 2020

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53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

31 March 2020

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DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

31 March 2020

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53BP1, an activator of ATM in response to DNA damage

31 March 2020

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53BP1, a mediator of the DNA damage checkpoint

31 March 2020

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p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

31 March 2020

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

31 March 2020

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

31 March 2020

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53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

31 March 2020

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BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

31 March 2020

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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

31 March 2020

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Regulation of homologous recombination in eukaryotes

31 March 2020

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Playing the end game: DNA double-strand break repair pathway choice

31 March 2020

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Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

31 March 2020

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Double-strand break end resection and repair pathway choice

31 March 2020

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53BP1 facilitates long-range DNA end-joining during V(D)J recombination

31 March 2020

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53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

31 March 2020

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53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

31 March 2020

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Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells

31 March 2020

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53BP1 is required for class switch recombination

31 March 2020

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Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage

31 March 2020

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Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

31 March 2020

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p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

31 March 2020

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More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

31 March 2020

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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

31 March 2020

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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

31 March 2020

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

31 March 2020

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

31 March 2020

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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

31 March 2020

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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

31 March 2020

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A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase

31 March 2020

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RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

31 March 2020

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The repair and signaling responses to DNA double-strand breaks

31 March 2020

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Ring finger protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damage

31 March 2020

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RAD18 transmits DNA damage signalling to elicit homologous recombination repair

31 March 2020

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Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

31 March 2020

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Push back to respond better: regulatory inhibition of the DNA double-strand break response

31 March 2020

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HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

31 March 2020

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The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response

31 March 2020

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TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes

31 March 2020

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The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases

31 March 2020

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Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

31 March 2020

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The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

31 March 2020

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DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

31 March 2020

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RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

31 March 2020

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Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

31 March 2020

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Sumoylation of MDC1 is important for proper DNA damage response

31 March 2020

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The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

31 March 2020

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SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

31 March 2020

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RNF4 is required for DNA double-strand break repair in vivo

31 March 2020

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

31 March 2020

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Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

31 March 2020

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

31 March 2020

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MDC1 is a mediator of the mammalian DNA damage checkpoint

31 March 2020

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Regulation of cell cycle progression and gene expression by H2A deubiquitination

31 March 2020

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Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability

31 March 2020

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53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

31 March 2020

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Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

31 March 2020

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An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks

31 March 2020

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

31 March 2020

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Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle

31 March 2020

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Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage

31 March 2020

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MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

31 March 2020

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Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage

31 March 2020

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PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis

31 March 2020

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A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

31 March 2020

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The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

31 March 2020

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A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome

31 March 2020

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Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks

31 March 2020

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The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

31 March 2020

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RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

31 March 2020

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Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor

31 March 2020

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L3MBTL1 recognition of mono- and dimethylated histones

31 March 2020

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The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

31 March 2020

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The chromatin response to DNA breaks: leaving a mark on genome integrity

31 March 2020

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Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair

31 March 2020

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Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

31 March 2020

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Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

31 March 2020

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Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating Enzymes

31 March 2020

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Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage

31 March 2020

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Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

31 March 2020

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

31 March 2020

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Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair

31 March 2020

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Requirement for the Phospho-H2AX Binding Module of Crb2 in Double-Strand Break Targeting and Checkpoint Activation

31 March 2020

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BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint

31 March 2020

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Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.

31 March 2020

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53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis.

31 March 2020

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Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks

31 March 2020

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Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.

31 March 2020

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The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres

31 March 2020

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RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

31 March 2020

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A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

31 March 2020

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53BP1 regulates DSB repair using Rif1 to control 5' end resection

31 March 2020

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Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching

31 March 2020

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RIF1 counteracts BRCA1-mediated end resection during DNA repair

31 March 2020

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A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.

31 March 2020

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Mammalian Rif1 contributes to replication stress survival and homology-directed repair

31 March 2020

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Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells

31 March 2020

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Rif1 regulates the replication timing domains on the human genome

31 March 2020

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Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication

31 March 2020

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The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection

31 March 2020

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PTIP promotes DNA double-strand break repair through homologous recombination

31 March 2020

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Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions

31 March 2020

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Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair

31 March 2020

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Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

31 March 2020

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Human CtIP promotes DNA end resection

31 March 2020

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The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression

31 March 2020

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Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks

31 March 2020

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Rap1p and telomere length regulation in yeast.

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24326623

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM3719

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Dimensions Publication ID

1 August 2017

1026269229

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