(Q38133962)

29 August 2017

Push back to respond better: regulatory inhibition of the DNA double-strand break response (English)

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29 August 2017

Stephanie Panier

1

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29 August 2017

Daniel Durocher

series ordinal

2

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29 August 2017

language of work or name

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4 September 2013

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Nature Reviews Molecular Cell Biology

29 August 2017

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29 August 2017

14

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29 August 2017

661-672

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29 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrm3659

29 August 2017

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cites work

Genetic regulatory mechanisms in the synthesis of proteins

2 references

https://pubmed.ncbi.nlm.nih.gov/24002223

31 March 2020

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Design principles of regulatory networks: searching for the molecular algorithms of the cell

1 reference

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

31 March 2020

1 reference

TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes

31 March 2020

1 reference

PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint

31 March 2020

1 reference

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

31 March 2020

1 reference

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

31 March 2020

1 reference

Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection

31 March 2020

1 reference

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

31 March 2020

1 reference

KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling

31 March 2020

1 reference

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

31 March 2020

1 reference

Global chromatin compaction limits the strength of the DNA damage response

31 March 2020

1 reference

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

31 March 2020

1 reference

A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery

31 March 2020

1 reference

A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication

31 March 2020

1 reference

Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response

31 March 2020

1 reference

Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.

31 March 2020

1 reference

Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition

31 March 2020

1 reference

Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair

31 March 2020

1 reference

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

31 March 2020

1 reference

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

31 March 2020

1 reference

Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1

31 March 2020

1 reference

BRIT1/MCPH1 links chromatin remodelling to DNA damage response.

31 March 2020

1 reference

MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage

31 March 2020

1 reference

Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent

31 March 2020

1 reference

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

31 March 2020

1 reference

Sumoylation of MDC1 is important for proper DNA damage response

31 March 2020

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Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation

31 March 2020

1 reference

RNF4 is required for DNA double-strand break repair in vivo

31 March 2020

1 reference

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

31 March 2020

1 reference

A SIM-ultaneous role for SUMO and ubiquitin

31 March 2020

1 reference

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

31 March 2020

1 reference

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

31 March 2020

1 reference

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

31 March 2020

1 reference

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

31 March 2020

1 reference

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

31 March 2020

1 reference

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

31 March 2020

1 reference

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

31 March 2020

1 reference

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

31 March 2020

1 reference

Regulatory ubiquitylation in response to DNA double-strand breaks

31 March 2020

1 reference

Regulation of DNA damage responses by ubiquitin and SUMO.

31 March 2020

1 reference

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

31 March 2020

1 reference

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

31 March 2020

1 reference

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

31 March 2020

1 reference

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

31 March 2020

1 reference

The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks

31 March 2020

1 reference

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

31 March 2020

1 reference

Structural basis and specificity of human otubain 1-mediated deubiquitination

31 March 2020

1 reference

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

31 March 2020

1 reference

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

31 March 2020

1 reference

Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.

31 March 2020

1 reference

The mechanism of OTUB1-mediated inhibition of ubiquitination

31 March 2020

1 reference

Ring finger protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damage

31 March 2020

1 reference

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

31 March 2020

1 reference

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

31 March 2020

1 reference

Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitin

31 March 2020

1 reference

The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments

31 March 2020

1 reference

BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation

31 March 2020

1 reference

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

31 March 2020

1 reference

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

31 March 2020

1 reference

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

31 March 2020

1 reference

The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection

31 March 2020

1 reference

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase

31 March 2020

1 reference

Breaking the chains: structure and function of the deubiquitinases

31 March 2020

1 reference

Proteasomes and proteasome activator 200 kDa (PA200) accumulate on chromatin in response to ionizing radiation

31 March 2020

1 reference

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response

31 March 2020

1 reference

The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases

31 March 2020

1 reference

Regulation of cell cycle progression and gene expression by H2A deubiquitination

31 March 2020

1 reference

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

31 March 2020

1 reference

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

31 March 2020

1 reference

An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks

31 March 2020

1 reference

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

31 March 2020

1 reference

Role of p97/VCP (Cdc48) in genome stability

31 March 2020

1 reference

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

31 March 2020

1 reference

Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair

31 March 2020

1 reference

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

31 March 2020

1 reference

Removal of shelterin reveals the telomere end-protection problem

31 March 2020

1 reference

How shelterin solves the telomere end-protection problem

31 March 2020

1 reference

A DNA damage checkpoint response in telomere-initiated senescence

31 March 2020

1 reference

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

31 March 2020

1 reference

DNA damage foci at dysfunctional telomeres

31 March 2020

1 reference

TRF2 Protects Human Telomeres from End-to-End Fusions

31 March 2020

1 reference

A two-step mechanism for TRF2-mediated chromosome-end protection

31 March 2020

1 reference

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

31 March 2020

1 reference

DNA damage signaling in response to double-strand breaks during mitosis

31 March 2020

1 reference

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint

31 March 2020

1 reference

DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells

31 March 2020

1 reference

The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0.

31 March 2020

1 reference

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

31 March 2020

1 reference

Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain

31 March 2020

1 reference

A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence

31 March 2020

1 reference

Changing the ubiquitin landscape during viral manipulation of the DNA damage response

31 March 2020

1 reference

Double-strand break end resection and repair pathway choice

31 March 2020

1 reference

Playing the end game: DNA double-strand break repair pathway choice

31 March 2020

1 reference

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

31 March 2020

1 reference

53BP1 regulates DSB repair using Rif1 to control 5' end resection

31 March 2020

1 reference

RIF1 counteracts BRCA1-mediated end resection during DNA repair

31 March 2020

1 reference

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

31 March 2020

1 reference

Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching

31 March 2020

1 reference

RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

31 March 2020

1 reference

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

31 March 2020

1 reference

Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

31 March 2020

1 reference

Human SIRT6 promotes DNA end resection through CtIP deacetylation

31 March 2020

1 reference

Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.

31 March 2020

1 reference

Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.

31 March 2020

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DNA helicase Srs2 disrupts the Rad51 presynaptic filament

31 March 2020

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The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

31 March 2020

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Inhibition of homologous recombination by the PCNA-interacting protein PARI

31 March 2020

1 reference

BRCA1 and BRCA2: different roles in a common pathway of genome protection

31 March 2020

1 reference

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

31 March 2020

1 reference

DNA double-strand break repair pathways, chromosomal rearrangements and cancer

31 March 2020

1 reference

Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint

31 March 2020

1 reference

Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication

31 March 2020

1 reference

Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.

31 March 2020

1 reference

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation

31 March 2020

1 reference

31 March 2020

Modes of p53 regulation

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p53 dynamics control cell fate

31 March 2020

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Guarding against collateral damage during chromatin transactions

31 March 2020

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Regulation of homologous recombination in eukaryotes

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM3659

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Dimensions Publication ID

29 August 2017

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