(Q39747969)

14 September 2017

title

Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition (English)

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14 September 2017

6

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14 September 2017

A Lindqvist

2

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author name string

L Macůrek

1

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14 September 2017

O Voets

3

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14 September 2017

J Kool

4

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14 September 2017

H R Vos

5

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14 September 2017

publication date

25 January 2010

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14 September 2017

language of work or name

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14 September 2017

volume

29

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14 September 2017

issue

15

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14 September 2017

page(s)

2281-2291

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DNA damage signalling guards against activated oncogenes and tumour progression

14 September 2017

cites work

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Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

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H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

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A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication

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PPM1D430, a novel alternative splicing variant of the human PPM1D, can dephosphorylate p53 and exhibits specific tissue expression

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Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

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Activation of multiple DNA repair pathways by sub-nuclear damage induction methods

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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

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A role for Saccharomyces cerevisiae histone H2A in DNA repair.

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Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

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Histone H2A phosphorylation in DNA double-strand break repair

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Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

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Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

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Wip1-deficient mice are resistant to common cancer genes

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

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Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry

21 January 2018

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A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery

21 January 2018

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

21 January 2018

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Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

21 January 2018

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Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.

21 January 2018

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Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression

21 January 2018

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The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair

21 January 2018

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The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

21 January 2018

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

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The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

21 January 2018

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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

21 January 2018

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.501

PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint

21 January 2018

1 reference

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Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint

21 January 2018

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Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

21 January 2018

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DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

21 January 2018

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21 January 2018

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Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase

21 January 2018

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Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

21 January 2018

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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

21 January 2018

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.501

Elimination of radiation-induced gamma-H2AX foci in mammalian nucleus can occur by histone exchange

21 January 2018

1 reference

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p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

21 January 2018

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NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.501

The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.501

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

21 January 2018

1 reference

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Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

21 January 2018

1 reference

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Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.501

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.501

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.501

1 reference

14 September 2017

1 reference