(Q34396844)

English

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

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16 February 2020

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation (English)

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16 February 2020

Paulo A. Ferreira

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16 February 2020

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Hemangi Patil

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16 February 2020

Arjun Saha

2

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16 February 2020

Eugene Senda

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16 February 2020

Kyoung-in Cho

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16 February 2020

MdEmdadul Haque

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16 February 2020

Minzhong Yu

6

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16 February 2020

Sunny Qiu

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16 February 2020

Dosuk Yoon

8

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16 February 2020

Ying Hao

9

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16 February 2020

Neal S Peachey

10

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16 February 2020

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3 September 2014

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16 February 2020

Journal of Biological Chemistry

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16 February 2020

289

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16 February 2020

43

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16 February 2020

29767-29789

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16 February 2020

Efficient induction of productive Cre-mediated recombination in retinal pigment epithelium

1 reference

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Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells

1 reference

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Down-modulation of nucleoporin RanBP2/Nup358 impaired chromosomal alignment and induced mitotic catastrophe

1 reference

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Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

1 reference

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Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

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Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability

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Mature peripheral RPE cells have an intrinsic capacity to proliferate; a potential regulatory mechanism for age-related cell loss

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Hallmarks of Cancer: The Next Generation

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DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

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mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.

1 reference

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PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.

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Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress

1 reference

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The nuclear pore complex: bridging nuclear transport and gene regulation

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Light-evoked responses of the retinal pigment epithelium: changes accompanying photoreceptor loss in the mouse.

1 reference

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The role of parkin in familial and sporadic Parkinson's disease

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Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies

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Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors.

1 reference

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Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression

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Functional roles of bestrophins in ocular epithelia

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RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system

1 reference

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Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2.

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Molecular basis of metastasis.

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6 July 2018

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons

1 reference

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Spatial and temporal coordination of mitosis by Ran GTPase

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Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha

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Inducible expression of cre recombinase in the retinal pigmented epithelium.

1 reference

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Oxidative damage-induced inflammation initiates age-related macular degeneration.

1 reference

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The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis

1 reference

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Comparison of human retinal pigment epithelium gene expression in macula and periphery highlights potential topographic differences in Bruch's membrane

1 reference

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Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function

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Complement C3 variant and the risk of age-related macular degeneration

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Cross talk between c-Met and epidermal growth factor receptor during retinal pigment epithelial wound healing

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RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism

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Macular degeneration: recent advances and therapeutic opportunities.

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Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents

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Functional modulation of parkin through physical interaction with SUMO-1.

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Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration

1 reference

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Analysis of a RanGTP-regulated gradient in mitotic somatic cells

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Parkin ubiquitinates and promotes the degradation of RanBP2

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The retinal pigment epithelium in visual function

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A systems analysis of importin-{alpha}-{beta} mediated nuclear protein import

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Complement factor H polymorphism and age-related macular degeneration

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Complex genomic rearrangements lead to novel primate gene function

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Nup358 integrates nuclear envelope breakdown with kinetochore assembly

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Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration

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The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import

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Systems analysis of Ran transport

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Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities

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Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

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Actin dynamics in living mammalian cells.

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RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex

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The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

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Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa

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Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4

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The retinal pigment epithelium: a versatile partner in vision.

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Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy

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Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1

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6 July 2018

Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region

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An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207991

6 July 2018

A giant nucleopore protein that binds Ran/TC4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207991

6 July 2018

Retina-specifically expressed novel subtypes of bovine cyclophilin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207991

6 July 2018

Cytoskeleton in normal and reactive human retinal pigment epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207991

6 July 2018

The long-term effects of visible light on the eye.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207991

6 July 2018

Acute necrotizing encephalopathy (ANE1): rare autosomal-dominant disorder presenting as acute transverse myelitis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586834

21 January 2018

Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586834

21 January 2018

Use of iris pigment epithelium to replace retinal pigment epithelium in age-related macular degeneration: a gene expression analysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586834

21 January 2018

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586834

21 January 2018

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586834

21 January 2018

NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586834

21 January 2018

Dominant encephalopathy mimicking mitochondrial disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586834

21 January 2018

Mice lacking Ran binding protein 1 are viable and show male infertility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586834

21 January 2018

The Nucleoporin Nup358/RanBP2 Promotes Nuclear Import in a Cargo- and Transport Receptor-Specific Manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586834

21 January 2018

Different Structural and Kinetic Requirements for the Interaction of Ran with the Ran-Binding Domains from RanBP2 and Importin-β

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.586834

21 January 2018

Age-related macular degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/25187515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apomorphine blocks form-deprivation myopia in chickens by a dopamine D2-receptor mechanism acting in retina or pigmented epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/25187515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sunlight and age-related macular degeneration. The Beaver Dam Eye Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/25187515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M114.586834

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25187515%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25187515%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25187515%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

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