(Q34408943)

English

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

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9 March 2020

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population (English)

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9 March 2020

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9 March 2020

Brian K Kennedy

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9 March 2020

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9 March 2020

Eileen M. Crimmins

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9 March 2020

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Valter D Longo

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9 March 2020

Jaime Guevara-Aguirre

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9 March 2020

Morgan E. Levine

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Morgan E Levine

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9 March 2020

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Jorge A Suarez

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9 March 2020

Sebastian Brandhorst

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9 March 2020

Priya Balasubramanian

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9 March 2020

Chia-Wei Cheng

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9 March 2020

Federica Madia

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9 March 2020

Mario G Mirisola

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9 March 2020

Junxiang Wan

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9 March 2020

Giuseppe Passarino

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9 March 2020

Pinchas Cohen

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9 March 2020

publication date

1 March 2014

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9 March 2020

Cell Metabolism

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9 March 2020

19

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9 March 2020

3

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9 March 2020

407-417

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9 March 2020

Dietary protein restriction inhibits tumor growth in human xenograft models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

High protein intake is associated with low prevalence of frailty among old Japanese women: a multicenter cross-sectional study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Will calorie restriction work in humans?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Growth hormone, inflammation and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Caloric restriction may reverse age-related autonomic decline in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Growth factors, nutrient signaling, and cardiovascular aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

GH and IGF1: roles in energy metabolism of long-living GH mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Red meat consumption and mortality: results from 2 prospective cohort studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Evaluation and comparison of food records, recalls, and frequencies for energy and protein assessment by using recovery biomarkers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Low-carbohydrate diets and all-cause and cause-specific mortality: two cohort studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Extending healthy life span--from yeast to humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

The genetics of ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Caloric restriction delays disease onset and mortality in rhesus monkeys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Current protein intake in America: analysis of the National Health and Nutrition Examination Survey, 2003-2004.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Diet and breast cancer risk reduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Energy balance and carcinogenesis: underlying pathways and targets for intervention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Low carbohydrate-high protein diet and mortality in a cohort of Swedish women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Aging, adiposity, and calorie restriction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

A simple model system for age-dependent DNA damage and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Low nutrient intake is an essential component of frailty in older persons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

The Mediterranean diet: science and practice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Calories do not explain extension of life span by dietary restriction in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

The plasticity of aging: insights from long-lived mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

TOR pathway: linking nutrient sensing to life span

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Insulin-like growth factors and neoplasia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

The frailty syndrome: a critical issue in geriatric oncology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Nutrient absorption and intestinal adaptation with ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Regulation of longevity and stress resistance by Sch9 in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Prolonged longevity of hypopituitary dwarf mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Genetic pathways that regulate ageing in model organisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Dwarf mice and the ageing process.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

A C. elegans mutant that lives twice as long as wild type

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Effects of caloric or protein restriction on insulin-like growth factor-I (IGF-I) and IGF-binding proteins in children and adults.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Protein restriction (PR) and caloric restriction (CR) compared: effects on DNA damage, carcinogenesis, and oxidative damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

6 July 2018

mTORC1 activity as a determinant of cancer risk--rationalizing the cancer-preventive effects of adiponectin, metformin, rapamycin, and low-protein vegan diets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

27 October 2018

Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

27 October 2018

The USDA Automated Multiple-Pass Method accurately estimates group total energy and nutrient intake.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

27 October 2018

Accuracy of dietary recall using the USDA five-step multiple-pass method in men: an observational validation study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

27 October 2018

Antioxidant enzymes, free-radical damage, and response to paraquat in liver and kidney of long-living growth hormone receptor/binding protein gene-disrupted mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

27 October 2018

Protection against diabetes-induced nephropathy in growth hormone receptor/binding protein gene-disrupted mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

27 October 2018

Involuntary weight loss in older outpatients: incidence and clinical significance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

27 October 2018

The effect of low protein-high dextrin diet and subsequent food restriction upon life prolongation in Fischer 344 male rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

27 October 2018

Dietary Protein Digestion and Absorption Rates and the Subsequent Postprandial Muscle Protein Synthetic Response Do Not Differ between Young and Elderly Men

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988204

9 December 2018

The endocrinology of aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal transport during the life span of the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary Protein Restriction Decreases Oxidative Protein Damage, Peroxidizability Index, and Mitochondrial Complex I Content in Rat Liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary Protein, Life-span, and Biochemical Variables in Female Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in dietary patterns over a 6-year period in an elderly population

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary changes favorably affect bone remodeling in older adults

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factors and subsequent risk of mortality in the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging in humans: a continuous 20-year study of physiologic and dietary parameters

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A prospective study on intake of animal products and risk of prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Length of Life and Nutrition in the Rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Splanchnic and whole-body leucine kinetics in young and elderly men

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men

1 reference

https://pubmed.ncbi.nlm.nih.gov/24606898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CMET.2014.02.006

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606898%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606898%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24606898%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

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