(Q34412530)

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Activation of AMP-activated Protein Kinase by Temozolomide Contributes to Apoptosis in Glioblastoma Cells via p53 Activation and mTORC1 Inhibition

scientific article published on September 29, 2010

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2 August 2017

Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition (English)

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Europe PubMed Central

PubMed publication ID

2 August 2017

Activation of AMP-activated Protein Kinase by Temozolomide Contributes to Apoptosis in Glioblastoma Cells via p53 Activation and mTORC1 Inhibition (English)

1 reference

10.1074/JBC.M110.164046

https://api.crossref.org/works/10.1074/JBC.M110.164046

23 July 2024

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apoptotic process

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author name string

Wen-bin Zhang

1

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Europe PubMed Central

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2 August 2017

Zhuo Wang

2

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2 August 2017

Fei Shu

3

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2 August 2017

Yong-hua Jin

4

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2 August 2017

Hong-yi Liu

5

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2 August 2017

Qiu-juan Wang

6

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2 August 2017

Yong Yang

7

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2 August 2017

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29 September 2010

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2 August 2017

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http://www.jbc.org/article/S0021925819762127/pdf

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20880848

23 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20880848/pdf/?tool=EBI

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23 July 2024

http://intl.jbc.org/cgi/content/abstract/285/52/40461

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20880848

23 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20880848/?tool=EBI

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20880848

23 July 2024

https://europepmc.org/articles/PMC3003344

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20880848

23 July 2024

https://europepmc.org/articles/PMC3003344?pdf=render

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Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20880848

23 July 2024

https://doi.org/10.1074/jbc.m110.164046

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20880848

23 July 2024

https://api.elsevier.com/content/article/PII:S0021925819762127?httpAccept=text/xml

1 reference

10.1074/JBC.M110.164046

https://api.crossref.org/works/10.1074/JBC.M110.164046

23 July 2024

https://api.elsevier.com/content/article/PII:S0021925819762127?httpAccept=text/plain

1 reference

10.1074/JBC.M110.164046

https://api.crossref.org/works/10.1074/JBC.M110.164046

23 July 2024

https://syndication.highwire.org/content/doi/10.1074/jbc.M110.164046

1 reference

10.1074/JBC.M110.164046

https://api.crossref.org/works/10.1074/JBC.M110.164046

23 July 2024

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

285

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

52

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

40461-40471

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition

1 reference

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The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

1 reference

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6 July 2018

AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells.

1 reference

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6 July 2018

AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes

1 reference

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6 July 2018

AMPK phosphorylation of raptor mediates a metabolic checkpoint

1 reference

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6 July 2018

Rapamycin inhibits cell growth by induction of apoptosis on hepatocellular carcinoma cells in vitro

1 reference

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6 July 2018

The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells

1 reference

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6 July 2018

Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours

1 reference

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6 July 2018

AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis

1 reference

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6 July 2018

Plantainoside D protects adriamycin-induced apoptosis in H9c2 cardiac muscle cells via the inhibition of ROS generation and NF-kappaB activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

AMPK, the metabolic syndrome and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

Post-translational modification of p53 in tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

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6 July 2018

Dysregulation of cellular signaling by HER2/neu in breast cancer

1 reference

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6 July 2018

5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

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6 July 2018

The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

1 reference

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6 July 2018

Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise

1 reference

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6 July 2018

Advances in chemotherapy for brain tumors

1 reference

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6 July 2018

Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003344

6 July 2018

Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164046

21 January 2018

Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164046

21 January 2018

Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

1 reference

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21 January 2018

Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53.

1 reference

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21 January 2018

p53 may mediate the mdr-1 expression via the WT1 gene in human vincristine-resistant leukemia/lymphoma cell lines.

1 reference

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21 January 2018

Dysregulation of cellular signaling by HER2 in breast cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.164046

21 January 2018

Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway.

1 reference

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27 October 2018

Multifaceted resistance of gliomas to temozolomide.

1 reference

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27 October 2018

Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells

1 reference

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27 October 2018

Involvement of the mismatch repair system in temozolomide-induced apoptosis

1 reference

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27 October 2018

Role of wild-type p53 on the antineoplastic activity of temozolomide alone or combined with inhibitors of poly(ADP-ribose) polymerase

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20880848

12 December 2020

based on heuristic

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Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

1 reference

https://pubmed.ncbi.nlm.nih.gov/20880848

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O6-alkylguanine DNA lesions trigger apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20880848

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Journal of Pharmacology and Experimental Therapeutics

22

285

884

author name string

Tentori

publication date

1998

1 reference

10.1074/JBC.M110.164046

https://api.crossref.org/works/10.1074/JBC.M110.164046

23 July 2024

Cancer Research

32

61

5843

author name string

Hirose

publication date

2001

1 reference

10.1074/JBC.M110.164046

https://api.crossref.org/works/10.1074/JBC.M110.164046

23 July 2024

Cancer Research

37

63

1382

author name string

Jimenez

publication date

2003

1 reference

10.1074/JBC.M110.164046

https://api.crossref.org/works/10.1074/JBC.M110.164046

23 July 2024

Identifiers

10.1074/JBC.M110.164046

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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