(Q34414291)

2 August 2017

title

Symptomatic relief of botulinum neurotoxin/a intoxication with aminopyridines: a new twist on an old molecule (English)

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2 August 2017

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Antonia Di Mola

3

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author name string

Alexander V Mayorov

1

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2 August 2017

Bert Willis

2

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2 August 2017

Derek Adler

4

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2 August 2017

Jennifer Borgia

5

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2 August 2017

Olin Jackson

6

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2 August 2017

Jie Wang

7

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2 August 2017

Yongyi Luo

8

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2 August 2017

Lei Tang

9

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2 August 2017

Richard J Knapp

10

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2 August 2017

Chandra Natarajan

11

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2 August 2017

Michael C Goodnough

12

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2 August 2017

Noam Zilberberg

13

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2 August 2017

Lance L Simpson

14

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2 August 2017

Kim D Janda

15

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2 August 2017

publication date

22 October 2010

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2 August 2017

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2 August 2017

volume

5

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2 August 2017

issue

12

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2 August 2017

page(s)

1183-1191

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The strange case of the botulinum neurotoxin: using chemistry and biology to modulate the most deadly poison

2 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Isolation of the first toxin from the scorpion Buthus occitanus israelis showing preference for Shaker potassium channels

6 July 2018

1 reference

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The Janus faces of botulinum neurotoxin: sensational medicine and deadly biological weapon

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Identification of the major steps in botulinum toxin action

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

The growing impact of click chemistry on drug discovery

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Rational modelling of the voltage-dependent K+ channel inactivation by aminopyridines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Clostridium botulinum and its neurotoxins: a metabolic and cellular perspective

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Botulinum Toxin as a Biological Weapon: Medical and Public Health Management

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

A residue in the intracellular vestibule of the pore is critical for gating and permeation in Ca2+-activated K+ (BKCa) channels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Quantitative assessment of sustained-release 4-aminopyridine for symptomatic treatment of multiple sclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Antagonism of botulinum toxin-induced muscle weakness by 3,4-diaminopyridine in rat phrenic nerve-hemidiaphragm preparations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Botulinum toxin type A: kinetics of calcium dependent paralysis of the neuromuscular junction and antagonism by drugs and animal toxins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Studies on the binding of botulinum toxin type A to the rat phrenic nerve-hemidiaphragm preparation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Equipotency of anti-curare activity of 4-aminopyridine and 3,4-diaminopyridine in anesthetized rats.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Differential effects of 4-aminopyridine and 2,4-diaminopyridine on the in vivo release of acetylcholine and dopamine in freely moving rats measured by intrastriatal dialysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

4-Aminopyridine in the treatment of Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

3,4-Diaminopyridine in the treatment of Lambert-Eaton myasthenic syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Preliminary trial of 3,4-diaminopyridine in patients with multiple sclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Mechanism of 4-aminopyridine action on voltage-gated potassium channels in lymphocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Properties and use of botulinum toxin and other microbial neurotoxins in medicine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Antagonism of the paralysis produced by botulinum toxin in the rat. The effects of tetraethylammonium, guanidine and 4-aminopyridine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Restoration of transmitter release in botulinum-poisoned skeletal muscle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Molecular docking study of the binding of aminopyridines within the K+ channel.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

[Treatment of severe botulism with 3,4-diaminopyridine]].

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

The nature of the receptor site for the reversible K+ channel blocking by aminopyridines

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Theoretical analysis of the molecular determinants responsible for the K(+) channel blocking by aminopyridines

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Can 4-aminopyridine be used to reverse anaesthesia and muscle relaxation?

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003761

Intimate details of the most poisonous poison

27 October 2018

1 reference

12 December 2020

Kinetic studies on the interaction between botulinum toxin type A and the cholinergic neuromuscular junction

1 reference

12 December 2020

Development of more potent 4-dimethylaminopyridine analogues

1 reference

12 December 2020

4-aminopyridine prevents the conformational changes associated with p/c-type inactivation in shaker channels

1 reference

12 December 2020

SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF SOME AMINOPYRIDINES, IMIDAZOPYRIDINES, AND TRIAZOLOPYRIDINES

1 reference

12 December 2020

Hemodynamic effects of 3,4-diaminopyridine in a swine model of verapamil toxicity

1 reference

12 December 2020

Human type A botulism and treatment with 3,4-diaminopyridine

1 reference

12 December 2020

Identifiers

DOI

10.1021/CB1002366

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2 August 2017

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2 August 2017

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