(Q34426872)

2 August 2017

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition (English)

1 reference

2 August 2017

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Sekyung Oh

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Scott Atwood

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Anthony Oro

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

17

Michelle Monje

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

23

Rameen Beroukhim

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Pratiti Bandopadhayay

6

object named as

Pratiti Bandopadhayay

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Yujie Tang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Sharareh Gholamin

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Simone Schubert

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Minde I Willardson

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Guillame Bergthold

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Sabran Masoud

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Brian Nguyen

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Nujsaubnusi Vue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Brianna Balansay

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Furong Yu

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Pamelyn Woo

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Spenser Chen

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Anitha Ponnuswami

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Ramon J Whitson

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Siddhartha Mitra

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Samuel H Cheshier

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Jun Qi

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Jean Y Tang

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Rob Wechsler-Reya

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Brian A Link

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

James E Bradner

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Yoon-Jae Cho

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

language of work or name

English

0 references

publication date

29 June 2014

1 reference

2 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

732-740

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nm.3613

10 June 2020

exact match

0 references

cites work

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6 July 2018

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6 July 2018

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Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists

6 July 2018

1 reference

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An ENU mutagenesis screen in zebrafish for visual system mutants identifies a novel splice-acceptor site mutation in patched2 that results in Colobomas.

6 July 2018

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Subgroup-specific structural variation across 1,000 medulloblastoma genomes

6 July 2018

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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

6 July 2018

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Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model

6 July 2018

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

6 July 2018

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

6 July 2018

1 reference

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GLI2 is a potential therapeutic target in pediatric medulloblastoma

6 July 2018

1 reference

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Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

6 July 2018

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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

6 July 2018

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Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.

6 July 2018

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Selective inhibition of BET bromodomains

6 July 2018

1 reference

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Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

6 July 2018

1 reference

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Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

6 July 2018

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

6 July 2018

1 reference

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Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

6 July 2018

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Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

6 July 2018

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Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival

6 July 2018

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Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

6 July 2018

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Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

6 July 2018

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Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp

6 July 2018

1 reference

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The EWS/FLI1 oncogenic transcription factor deregulates GLI1.

6 July 2018

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A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway

6 July 2018

1 reference

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Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.

6 July 2018

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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

6 July 2018

1 reference

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

6 July 2018

1 reference

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Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

6 July 2018

1 reference

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The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

6 July 2018

1 reference

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Cilia and Hedgehog responsiveness in the mouse

6 July 2018

1 reference

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A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2

6 July 2018

1 reference

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Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

6 July 2018

1 reference

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

MULTIPLE BASAL-CELL NEVI SYNDROME. AN ANALYSIS OF A SYNDROME CONSISTING OF MULTIPLE NEVOID BASAL-CELL CARCINOMA, JAW CYSTS, SKELETAL ANOMALIES, MEDULLOBLASTOMA, AND HYPORESPONSIVENESS TO PARATHORMONE.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Small molecule modulation of Smoothened activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Mutations in SUFU predispose to medulloblastoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Structure and function of a human TAFII250 double bromodomain module

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Structure and ligand of a histone acetyltransferase bromodomain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Altered neural cell fates and medulloblastoma in mouse patched mutants

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

6 July 2018

1 reference

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

21 January 2018

1 reference

Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors.

21 January 2018

1 reference

Heat-shock-mediated conditional regulation of hedgehog/gli signaling in zebrafish

21 January 2018

1 reference

Teratogen-mediated inhibition of target tissue response to Shh signaling.

21 January 2018

1 reference

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

21 January 2018

1 reference

Midline signalling is required for Pax gene regulation and patterning of the eyes.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108909

Chronologic evaluation of teratogenicity in sheep fed Veratrum californicum

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24973920

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NM.3613

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24973920%20AND%20SRC:MED&resulttype=core&format=json