(Q34438156)

2 August 2017

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title

The emerging field of lipidomics (English)

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2 August 2017

1

Markus R Wenk

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2 August 2017

1 July 2005

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Nature Reviews Drug Discovery

2 August 2017

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2 August 2017

4

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2 August 2017

594-610

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2 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrd1776

2 August 2017

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cites work

Lipidomics is emerging

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Protein-lipid interactions on the surfaces of cell membranes

31 March 2020

1 reference

Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes

31 March 2020

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Structure of Type IIβ Phosphatidylinositol Phosphate Kinase

31 March 2020

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The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity

31 March 2020

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Refinement of the fluid-mosaic model of membrane structure

31 March 2020

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Proton-induced fusion of oleic acid-phosphatidylethanolamine liposomes

31 March 2020

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Lipids in biological membrane fusion

31 March 2020

1 reference

Ternary phase diagram of dipalmitoyl-PC/dilauroyl-PC/cholesterol: nanoscopic domain formation driven by cholesterol

31 March 2020

1 reference

Inositol trisphosphate and calcium signalling

31 March 2020

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The protein kinase C family for neuronal signaling

31 March 2020

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Phosphatidic acid, a key intermediate in lipid metabolism.

31 March 2020

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How versatile are inositol phosphate kinases?

31 March 2020

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Eicosanomics: targeted lipidomics of eicosanoids in biological systems

31 March 2020

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Sphingomyelin and cholesterol: from membrane biophysics and rafts to potential medical applications

31 March 2020

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Sphingolipids in inflammation: roles and implications

31 March 2020

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Ceramide synthesis and metabolism as a target for cancer therapy.

31 March 2020

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Physiological and pathological actions of sphingosine 1-phosphate.

31 March 2020

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Sphingosine kinase signalling in immune cells

31 March 2020

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Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane

31 March 2020

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Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals

31 March 2020

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Subcellular targeting by membrane lipids

31 March 2020

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Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain

31 March 2020

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FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P

31 March 2020

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The role of phosphoinositides in membrane transport

31 March 2020

1 reference

Vacuole Size Control: Regulation of PtdIns(3,5)P2Levels by the Vacuole-associated Vac14-Fig4 Complex, a PtdIns(3,5)P2-specific Phosphatase

31 March 2020

1 reference

Lipopenia and skin barrier abnormalities in DGAT2-deficient mice

31 March 2020

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Lipid metabolic enzymes: emerging drug targets for the treatment of obesity

31 March 2020

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Orlistat in the treatment of obesity

31 March 2020

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The lipid phosphatase SHIP2 controls insulin sensitivity

31 March 2020

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Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity

31 March 2020

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Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss

31 March 2020

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Intracellular organization of insulin signaling and GLUT4 translocation

31 March 2020

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Mechanism of free fatty acid-induced insulin resistance in humans

31 March 2020

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Joe Goldstein and Mike Brown: from cholesterol homeostasis to new paradigms in membrane biology

31 March 2020

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The SREBP pathway--insights from Insigs and insects

31 March 2020

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Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone

31 March 2020

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G-protein signaling through tubby proteins

31 March 2020

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Tubby proteins: the plot thickens

31 March 2020

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PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

31 March 2020

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Dynamics of phosphoinositides in membrane retrieval and insertion

31 March 2020

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

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Phosphoinositide signaling disorders in human diseases

31 March 2020

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Long-lived Drosophila with overexpressed dFOXO in adult fat body.

31 March 2020

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PI 3-kinase inhibition: a therapeutic target for respiratory disease

31 March 2020

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Towards an understanding of isoform specificity in phosphoinositide 3-kinase signalling in lymphocytes

31 March 2020

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Phosphatases as small-molecule targets: inhibiting the endogenous inhibitors of kinases

31 March 2020

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Phosphoinositide 3-kinases as targets for therapeutic intervention

31 March 2020

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Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

31 March 2020

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Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals

31 March 2020

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Biologically active sphingolipids in cancer pathogenesis and treatment

31 March 2020

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An oncogenic role of sphingosine kinase

31 March 2020

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Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity

31 March 2020

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Biological activities and metabolism of the lysophosphoinositides and glycerophosphoinositols.

31 March 2020

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Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors for prostate cancer chemoprevention.

31 March 2020

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Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

31 March 2020

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GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

31 March 2020

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Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.

31 March 2020

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The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

31 March 2020

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Glucocerebrosidase mutations in subjects with parkinsonism

31 March 2020

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A defect in cholesterol esterification in Niemann-Pick disease (type C) patients

31 March 2020

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The pathophysiology and mechanisms of NP-C disease.

31 March 2020

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Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

31 March 2020

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Structural mimicry in bacterial virulence

31 March 2020

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Protein kinase G from pathogenic mycobacteria promotes survival within macrophages

31 March 2020

1 reference

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

31 March 2020

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Toll-like receptor signalling

31 March 2020

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31 March 2020

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Functional rafts in cell membranes

31 March 2020

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A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

31 March 2020

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A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains

31 March 2020

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Essential role for cholesterol in entry of mycobacteria into macrophages

31 March 2020

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Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane

31 March 2020

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Multimerization of human immunodeficiency virus type 1 Gag promotes its localization to barges, raft-like membrane microdomains

31 March 2020

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Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts

31 March 2020

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Ceramide, a target for antiretroviral therapy

31 March 2020

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Influenza viruses select ordered lipid domains during budding from the plasma membrane

31 March 2020

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Virion-associated cholesterol is critical for the maintenance of HIV-1 structure and infectivity.

31 March 2020

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Phospholipid analogs against HIV-1 infection and disease

31 March 2020

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Human immunodeficiency virus and host cell lipids. Interesting pathways in research for a new HIV therapy

31 March 2020

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Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade

31 March 2020

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Identification and macrophage-activating activity of glycolipids released from intracellular Mycobacterium bovis BCG.

31 March 2020

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Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest.

31 March 2020

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Salmonella modulates vesicular traffic by altering phosphoinositide metabolism

31 March 2020

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MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence

31 March 2020

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Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis

31 March 2020

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Bacterial injectisomes: needle length does matter.

31 March 2020

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Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis

31 March 2020

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Activation of Akt/protein kinase B in epithelial cells by the Salmonella typhimurium effector sigD.

31 March 2020

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Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes

31 March 2020

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CD1-restricted T cell recognition of microbial lipoglycan antigens

31 March 2020

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CD1: antigen presentation and T cell function

31 March 2020

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CD1 assembly and the formation of CD1-antigen complexes

31 March 2020

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Saposin C is required for lipid presentation by human CD1b

31 March 2020

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Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved

31 March 2020

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Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids

31 March 2020

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Liquid chromatography/mass spectrometry of phospholipids using electrospray ionization

31 March 2020

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Electrospray mass spectrometry of phospholipids

31 March 2020

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Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics

31 March 2020

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Lipid species profiling: a high-throughput approach to identify lipid compositional changes and determine the function of genes involved in lipid metabolism and signaling.

31 March 2020

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Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry

31 March 2020

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Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry

31 March 2020

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Electrospray ionization mass spectrometry analysis of changes in phospholipids in RBL-2H3 mastocytoma cells during degranulation

31 March 2020

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Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry

31 March 2020

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Quantitative profiling of phospholipids by multiple precursor ion scanning on a hybrid quadrupole time-of-flight mass spectrometer

31 March 2020

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High-resolution field desorption/ionization fourier transform ion cyclotron resonance mass analysis of nonpolar molecules

31 March 2020

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Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry.

31 March 2020

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Characterization and direct quantitation of ceramide molecular species from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry

31 March 2020

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Coupling thin-layer chromatography with vibrational cooling matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for the analysis of ganglioside mixtures

31 March 2020

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Profiling Membrane Lipids in Plant Stress Responses

31 March 2020

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Detection of individual phospholipids in lipid mixtures by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: phosphatidylcholine prevents the detection of further species

31 March 2020

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Limits for the detection of (poly-)phosphoinositides by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS).

31 March 2020

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A shotgun tandem mass spectrometric analysis of phospholipids with normal-phase and/or reverse-phase liquid chromatography/electrospray ionization mass spectrometry

31 March 2020

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Automated quantitative analysis of complex lipidomes by liquid chromatography/mass spectrometry.

31 March 2020

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Quantitative high-performance liquid chromatography analysis of plant phospholipids and glycolipids using light-scattering detection

31 March 2020

1 reference

Nonradioactive analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection

31 March 2020

1 reference

Separation of phospholipids in microfluidic chip device: application to high-throughput screening assays for lipid-modifying enzymes.

31 March 2020

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Capillary electrophoresis of cardiolipin with on-line dye interaction and spectrophotometric detection

31 March 2020

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Personal metabolomics as a next generation nutritional assessment

31 March 2020

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Effect of a single cis double bond on the structures of a phospholipid bilayer

31 March 2020

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Novel NMR tools to study structure and dynamics of biomembranes

31 March 2020

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The protein-lipid interface: perspectives from magnetic resonance and crystal structures

31 March 2020

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Immobilized lipid in acetylcholine receptor-rich membranes from Torpedo marmorata

31 March 2020

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Solid-state nuclear magnetic resonance investigation of protein and polypeptide structure

31 March 2020

1 reference

An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse

31 March 2020

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Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

31 March 2020

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Phosphoinositide signaling; from affinity probes to pharmaceutical targets

31 March 2020

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Global analysis of protein activities using proteome chips

31 March 2020

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Role of membrane organization and membrane domains in endocytic lipid trafficking

31 March 2020

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Transbilayer movement of phospholipids in biogenic membranes

31 March 2020

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Assembly of Endocytosis-Associated Proteins on Liposomes

31 March 2020

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Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

31 March 2020

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A colorimetric assay for rapid screening of antimicrobial peptides

31 March 2020

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Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis

31 March 2020

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A comprehensive classification system for lipids

31 March 2020

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Computational lipidomics: a multiplexed analysis of dynamic changes in membrane lipid composition during signal transduction

31 March 2020

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Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators

31 March 2020

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Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae

31 March 2020

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Pleckstrin homology domains: not just for phosphoinositides

31 March 2020

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Differential metabolic networks unravel the effects of silent plant phenotypes

31 March 2020

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Metabolic control analysis in drug discovery and disease

31 March 2020

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Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

31 March 2020

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A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage

31 March 2020

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Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria

31 March 2020

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Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas

31 March 2020

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Chemical genetic approaches for the elucidation of signaling pathways

31 March 2020

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Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin

31 March 2020

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The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action.

31 March 2020

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T cell activation by lipopeptide antigens

31 March 2020

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CD36 is a sensor of diacylglycerides

31 March 2020

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Structure of a cannabinoid receptor and functional expression of the cloned cDNA

31 March 2020

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Isolation and structure of a brain constituent that binds to the cannabinoid receptor

31 March 2020

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31 March 2020

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Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

31 March 2020

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Assignment of endogenous substrates to enzymes by global metabolite profiling

31 March 2020

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A ratiometric expressible FRET sensor for phosphoinositides displays a signal change in highly dynamic membrane structures in fibroblasts

31 March 2020

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Fluorescent biosensor for quantitative real-time measurements of inositol 1,4,5-trisphosphate in single living cells

31 March 2020

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Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic

31 March 2020

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Antagonists of myo-inositol 3,4,5,6-tetrakisphosphate allow repeated epithelial chloride secretion

31 March 2020

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Phosphorylation of proteins by inositol pyrophosphates

31 March 2020

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Enzymatic release of antitumor ether lipids by specific phospholipase A2 activation of liposome-forming prodrugs.

31 March 2020

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HPLC-MS/MS analysis of the products generated from all-trans-retinoic acid using recombinant human CYP26A.

31 March 2020

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Metabonomics in toxicology: a review

31 March 2020

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Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review

31 March 2020

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Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases.

31 March 2020

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Raised levels of F(2)-isoprostanes and prostaglandin F(2alpha) in different rheumatic diseases

31 March 2020

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Direct observation of lipid hydroperoxides in phospholipid vesicles by electrospray mass spectrometry

31 March 2020

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High-resolution analysis by nano-electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry for the identification of molecular species of phospholipids and their oxidized metabolites.

31 March 2020

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31 March 2020

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Cardiolipin provides specificity for targeting of tBid to mitochondria

31 March 2020

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A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis

31 March 2020

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Molecular circuits of resolution: formation and actions of resolvins and protectins

31 March 2020

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Metabolomics in systems biology

31 March 2020

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PIP(2) and proteins: interactions, organization, and information flow

31 March 2020

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Structural basis for lipid modulation of nicotinic acetylcholine receptor function

31 March 2020

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Phosphoinositide recognition domains

31 March 2020

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Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase

31 March 2020

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7 January 2021

Phospholipases: structural and functional motifs for working at an interface

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7 January 2021

Visualizing cellular phosphoinositide pools with GFP-fused protein-modules

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7 January 2021

Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

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7 January 2021

The complex and intriguing lives of PIP2 with ion channels and transporters

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7 January 2021

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

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7 January 2021

Identifiers

DOI

10.1038/NRD1776

1 reference

2 August 2017

1 reference

PubMed ID

16052242