(Q34452740)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974861%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974861%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1

1 reference

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14 January 2020

4

Jeffrey D Esko

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974861%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

author name string

Mark M Fuster

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974861%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Roger Lawrence

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974861%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

language of work or name

English

0 references

publication date

25 October 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974861%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

number of pages

9

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974861%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

volume

286

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974861%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974861%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

page(s)

737-745

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974861%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

14 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3013032/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Evolutionary differences in glycosaminoglycan fine structure detected by quantitative glycan reductive isotope labeling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Surfen, a small molecule antagonist of heparan sulfate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Heparan sulphate proteoglycans fine-tune mammalian physiology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Structural basis for ligand and heparin binding to neuropilin B domains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

The inflammatory response in stroke

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Direct observation of individual endogenous protein complexes in situ by proximity ligation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

VEGF receptor signalling - in control of vascular function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Signaling mechanisms regulating endothelial permeability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

VEGF165-binding sites within heparan sulfate encompass two highly sulfated domains and can be liberated by K5 lyase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Protamine and protamine reactions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Mammalian Brain Morphogenesis and Midline Axon Guidance Require Heparan Sulfate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Growing and shaping the vascular tree: multiple roles for VEGF

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

The splice variants of vascular endothelial growth factor (VEGF) and their receptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Functions of cell surface heparan sulfate proteoglycans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Identification of a heparin binding peptide on the extracellular domain of the KDR VEGF receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Selective binding of VEGF121 to one of the three vascular endothelial growth factor receptors of vascular endothelial cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Interactions between the Flk-1 receptor, vascular endothelial growth factor, and cell surface proteoglycan identified with a soluble receptor reagent

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Vascular permeability factor (VPF, VEGF) in tumor biology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Heparin modulates the interaction of VEGF165 with soluble and cell associated flk-1 receptors.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke

6 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177006

Pathophysiological consequences of VEGF-induced vascular permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177006

Heparin regulates vascular endothelial growth factor165-dependent mitogenic activity, tube formation, and its receptor phosphorylation of human endothelial cells. Comparison of the effects of heparin and modified heparins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177006

Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177006

Puromycin-based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood-brain barrier-specific properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177006

Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177006

Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177006

Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177006

The fourth immunoglobulin-like loop in the extracellular domain of FLT-1, a VEGF receptor, includes a major heparin-binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177006

Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 signaling in brain endothelial cells. Specific role for glypican-1 in glioma angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177006

Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.177006

Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3013032

The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules

27 October 2018

1 reference

12 December 2020

Regulation of vascular endothelial growth factor binding and activity by extracellular pH

1 reference

12 December 2020

Vascular reactions to histamine, histamine-liberator and leukotaxine in the skin of guinea-pigs

1 reference

12 December 2020

Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.177006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974861%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20974861%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PubMed publication ID

20974861

1 reference