(Q34455068)

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The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms (English)

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Europe PubMed Central

PubMed publication ID

2 August 2017

crystal structure

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based on heuristic

inferred from title

Thierry Meinnel

6

object named as

Thierry Meinnel

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Europe PubMed Central

PubMed publication ID

2 August 2017

Carmela Giglione

object named as

Carmela Giglione

5

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Sonia Fieulaine

1

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Europe PubMed Central

PubMed publication ID

2 August 2017

Céline Juillan-Binard

2

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Europe PubMed Central

PubMed publication ID

2 August 2017

Alexandre Serero

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Frédéric Dardel

4

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Europe PubMed Central

PubMed publication ID

2 August 2017

Jean-Luc Ferrer

7

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Europe PubMed Central

PubMed publication ID

2 August 2017

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publication date

28 September 2005

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Europe PubMed Central

PubMed publication ID

2 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

2 August 2017

280

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Europe PubMed Central

PubMed publication ID

2 August 2017

51

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

42315-42324

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Functional and developmental impact of cytosolic protein N-terminal methionine excision in Arabidopsis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Processing of the N termini of nascent polypeptide chains requires deformylation prior to methionine removal

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

A survey of polypeptide deformylase function throughout the eubacterial lineage.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Structure-function relationships within the peptide deformylase family. Evidence for a conserved architecture of the active site involving three conserved motifs and a metal ion.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Mapping of the active site zinc ligands of peptide deformylase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Isolation and crystallization of functionally competent Escherichia coli peptide deformylase forms containing either iron or nickel in the active site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Zinc coordination, function, and structure of zinc enzymes and other proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Substrate recognition and selectivity of peptide deformylase. Similarities and differences with metzincins and thermolysin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Organellar peptide deformylases: universality of the N-terminal methionine cleavage mechanism.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

A new subclass of the zinc metalloproteases superfamily revealed by the solution structure of peptide deformylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Iron center, substrate recognition and mechanism of peptide deformylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Structural basis for the design of antibiotics targeting peptide deformylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Deformylase as a novel antibacterial target.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Peptide deformylase: a target for novel antibiotics?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Peptide deformylase of eukaryotic protists: a target for new antiparasitic agents?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Pharmacokinetics in animals and humans of a first-in-class peptide deformylase inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Comparative antimicrobial characterization of LBM415 (NVP PDF-713), a new peptide deformylase inhibitor of clinical importance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Taking inventory: antibacterial agents currently at or beyond phase 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Distinctive features of the two classes of eukaryotic peptide deformylases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Control of protein life-span by N-terminal methionine excision

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

MOLREP: an Automated Program for Molecular Replacement

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Unique structural characteristics of peptide deformylase from pathogenic bacterium Leptospira interrogans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Raster3D: photorealistic molecular graphics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Structure of peptide deformylase and identification of the substrate binding site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Crystal structure of the Escherichia coli peptide deformylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

An improved crystal form of Plasmodium falciparum peptide deformylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Enzymatic properties of a new peptide deformylase from pathogenic bacterium Leptospira interrogans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

On the size of the active site in proteases. I. Papain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Solution structure of nickel-peptide deformylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Control of peptide deformylase activity by metal cations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Structures of E. coli peptide deformylase bound to formate: insight into the preference for Fe2+ over Zn2+ as the active site metal

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Cloning, high-level expression, purification and crystallization of peptide deformylase from Leptospira interrogans.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Characterization of an eukaryotic peptide deformylase from Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

ESPript: analysis of multiple sequence alignments in PostScript

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507155200

21 January 2018

Identifiers

10.1074/JBC.M507155200

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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