(Q34479821)

2 August 2017

Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species (English)

1 reference

2 August 2017

reactive oxygen species

1 reference

13

George Wilding

1 reference

2 August 2017

1

Sheng-Xiong Huang

1 reference

2 August 2017

9

Jeremy R Lohman

1 reference

2 August 2017

Bong-Sik Yun

2

1 reference

2 August 2017

Ming Ma

3

1 reference

2 August 2017

Hirak S Basu

4

1 reference

2 August 2017

Dawn R Church

5

1 reference

2 August 2017

Gudrun Ingenhorst

6

1 reference

2 August 2017

Yong Huang

7

1 reference

2 August 2017

Dong Yang

8

1 reference

2 August 2017

Gong-Li Tang

10

1 reference

2 August 2017

Jianhua Ju

11

1 reference

2 August 2017

Tao Liu

12

1 reference

2 August 2017

Ben Shen

14

1 reference

2 August 2017

language of work or name

English

0 references

publication date

8 June 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

1 reference

2 August 2017

112

1 reference

2 August 2017

27

1 reference

2 August 2017

8278-8283

1 reference

The "two-faced" effects of reactive oxygen species and the lipid peroxidation product 4-hydroxynonenal in the hallmarks of cancer

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog Fold

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Synthesis and characterization of a small analogue of the anticancer natural product leinamycin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

ROS-activated anticancer prodrugs: a new strategy for tumor-specific damage.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

ROS-inducible DNA cross-linking agent as a new anticancer prodrug building block

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Aminoferrocene-based prodrugs activated by reactive oxygen species.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Hydrogen peroxide inducible DNA cross-linking agents: targeted anticancer prodrugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Characterization of the lnmKLM genes unveiling key intermediates for β-alkylation in leinamycin biosynthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Hydrogen peroxide activated matrix metalloproteinase inhibitors: a prodrug approach

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Bifunctional acyltransferase/decarboxylase LnmK as the missing link for beta-alkylation in polyketide biosynthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

The role of polyamine catabolism in anti-tumour drug response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Mechanisms of DNA damage by leinamycin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Effect of antioxidants on androgen-induced AP-1 and NF-kappaB DNA-binding activity in prostate carcinoma cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Prooxidant states and tumor promotion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Thiol-independent DNA alkylation by leinamycin.

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1506761112

Chemical properties of the leinamycin-guanine adduct in DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1506761112

Small molecules that mimic the thiol-triggered alkylating properties seen in the natural product leinamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1506761112

Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1506761112

Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1506761112

Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4500275

Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine

27 October 2018

1 reference

12 December 2020

Antitumor activity of KF22678, a novel thioester derivative of leinamycin

1 reference

12 December 2020

DNA strand scission by the novel antitumor antibiotic leinamycin

1 reference

12 December 2020

Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation

1 reference

12 December 2020

Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1506761112

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference