(Q34486530)

2 August 2017

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title

Short- and long-term effects of chromosome mis-segregation and aneuploidy (English)

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2 August 2017

2

Angelika Amon

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Stefano Santaguida

object named as

Stefano Santaguida

series ordinal

1

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publication date

1 July 2015

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Nature Reviews Molecular Cell Biology

2 August 2017

published in

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2 August 2017

volume

16

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2 August 2017

issue

8

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2 August 2017

page(s)

473-485

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Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

2 August 2017

cites work

1 reference

Losing balance: the origin and impact of aneuploidy in cancer

31 March 2020

1 reference

Chromosomal instability and aneuploidy in cancer: from yeast to man

31 March 2020

1 reference

The spindle-assembly checkpoint in space and time

31 March 2020

1 reference

Causes and consequences of aneuploidy in cancer.

31 March 2020

1 reference

Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells

31 March 2020

1 reference

Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome

31 March 2020

1 reference

Effects of aneuploidy on genome structure, expression, and interphase organization in Arabidopsis thaliana

31 March 2020

1 reference

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells.

31 March 2020

1 reference

Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast.

31 March 2020

1 reference

Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome

31 March 2020

1 reference

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

31 March 2020

1 reference

Effects of aneuploidy on cellular physiology and cell division in haploid yeast

31 March 2020

1 reference

Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes

31 March 2020

1 reference

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

31 March 2020

1 reference

To err (meiotically) is human: the genesis of human aneuploidy

31 March 2020

1 reference

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

31 March 2020

1 reference

Meiotic recombination and segregation of human-derived artificial chromosomes in Saccharomyces cerevisiae

31 March 2020

1 reference

Fidelity of mitotic chromosome transmission

31 March 2020

1 reference

Genome-wide genetic analysis of polyploidy in yeast

31 March 2020

1 reference

Examining the link between chromosomal instability and aneuploidy in human cells

31 March 2020

1 reference

Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells

31 March 2020

1 reference

Constitutional aneuploidy in the normal human brain.

31 March 2020

1 reference

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

31 March 2020

1 reference

Aneuploidy as a mechanism for stress-induced liver adaptation.

31 March 2020

1 reference

Frequent aneuploidy among normal human hepatocytes

31 March 2020

1 reference

The ploidy conveyor of mature hepatocytes as a source of genetic variation.

31 March 2020

1 reference

Chromosomal variation in neurons of the developing and adult mammalian nervous system

31 March 2020

1 reference

Individual adult human neurons display aneuploidy: detection by fluorescence in situ hybridization and single neuron PCR.

31 March 2020

1 reference

Aneuploidy and confined chromosomal mosaicism in the developing human brain.

31 March 2020

1 reference

Chromosome-specific accumulation of aneuploidy in the aging mouse brain

31 March 2020

1 reference

Mosaic copy number variation in human neurons

31 March 2020

1 reference

Single-cell, genome-wide sequencing identifies clonal somatic copy-number variation in the human brain

31 March 2020

1 reference

Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations

31 March 2020

1 reference

DNA breaks and chromosome pulverization from errors in mitosis

31 March 2020

1 reference

Resolution of anaphase bridges in cancer cells

31 March 2020

1 reference

DNA lesions sequestered in micronuclei induce a local defective-damage response.

31 March 2020

1 reference

Nuclear envelope defects impede a proper response to micronuclear DNA lesions

31 March 2020

1 reference

Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks

31 March 2020

1 reference

Nuclear reconstitution in vitro: stages of assembly around protein-free DNA

31 March 2020

1 reference

Catastrophic nuclear envelope collapse in cancer cell micronuclei.

31 March 2020

1 reference

Chromothripsis from DNA damage in micronuclei.

31 March 2020

1 reference

Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements

31 March 2020

1 reference

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

31 March 2020

1 reference

Chromothripsis and cancer: causes and consequences of chromosome shattering

31 March 2020

1 reference

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements

31 March 2020

1 reference

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.

31 March 2020

1 reference

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

31 March 2020

1 reference

Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

31 March 2020

1 reference

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

31 March 2020

1 reference

Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis

31 March 2020

1 reference

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

31 March 2020

1 reference

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

31 March 2020

1 reference

Prolonged mitosis versus tetraploid checkpoint: how p53 measures the duration of mitosis.

31 March 2020

1 reference

Mechanism of G1-like arrest by low concentrations of paclitaxel: next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis

31 March 2020

1 reference

Identification of aneuploidy-selective antiproliferation compounds

31 March 2020

1 reference

Aneuploidy: cells losing their balance

31 March 2020

1 reference

Identification of aneuploidy-tolerating mutations

31 March 2020

1 reference

Gene expression and distribution of Swi6 in partial aneuploids of the fission yeast Schizosaccharomyces pombe

31 March 2020

1 reference

Global up-regulation of chromosome 21 gene expression in the developing down syndrome brain

31 March 2020

1 reference

Down syndrome: Gene dosage at the transcriptional level in skin fibroblasts

31 March 2020

1 reference

Trans-acting dosage effects on the expression of model gene systems in maize aneuploids

31 March 2020

1 reference

Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression.

31 March 2020

1 reference

Buffering and the evolution of chromosome-wide gene regulation

31 March 2020

1 reference

Painting of fourth, a chromosome-specific protein in Drosophila

31 March 2020

1 reference

Differential gene expression and epiregulation of alpha zein gene copies in maize haplotypes

31 March 2020

1 reference

Toxic effects of excess cloned centromeres

31 March 2020

1 reference

Aneuploidy causes proteotoxic stress in yeast

31 March 2020

1 reference

Human copy number variation and complex genetic disease.

31 March 2020

1 reference

Gene copy-number alterations: a cost-benefit analysis

31 March 2020

1 reference

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

31 March 2020

1 reference

Pathogenesis of Charcot-Marie-Tooth 1A (CMT1A) neuropathy

31 March 2020

1 reference

Regulation of tubulin levels and microtubule assembly in Saccharomyces cerevisiae: consequences of altered tubulin gene copy number

31 March 2020

1 reference

Robustness analysis of cellular systems using the genetic tug-of-war method

31 March 2020

1 reference

Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast

31 March 2020

1 reference

Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

31 March 2020

1 reference

Translating dosage compensation to trisomy 21

31 March 2020

1 reference

Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes

31 March 2020

1 reference

Transcriptional consequences of aneuploidy

31 March 2020

1 reference

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.

31 March 2020

1 reference

Unique features of the transcriptional response to model aneuploidy in human cells

31 March 2020

1 reference

Comparative genomics of the environmental stress response in ascomycete fungi

31 March 2020

1 reference

Genomic expression programs in the response of yeast cells to environmental changes

31 March 2020

1 reference

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

31 March 2020

1 reference

Most random gene expression signatures are significantly associated with breast cancer outcome

31 March 2020

1 reference

A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis

31 March 2020

1 reference

Adapting proteostasis for disease intervention

31 March 2020

1 reference

Cellular strategies for controlling protein aggregation

31 March 2020

1 reference

Protein folding and misfolding

31 March 2020

1 reference

The Yin and Yang of protein folding

31 March 2020

1 reference

A role for ubiquitin in selective autophagy

31 March 2020

1 reference

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

31 March 2020

1 reference

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

31 March 2020

1 reference

HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells.

31 March 2020

1 reference

HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II

31 March 2020

1 reference

Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources

31 March 2020

1 reference

Growth arrest and chromosome instability in aneuploid yeast.

31 March 2020

1 reference

Studies on Down's syndrome in tissue culture. I. Growth rates and protein contents of fibroblast cultures

31 March 2020

1 reference

Aneuploid yeast strains exhibit defects in cell growth and passage through START

31 March 2020

1 reference

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

31 March 2020

1 reference

Aneuploidy acts both oncogenically and as a tumor suppressor

31 March 2020

1 reference

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

31 March 2020

1 reference

Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method

31 March 2020

1 reference

The landscape of somatic copy-number alteration across human cancers

31 March 2020

1 reference

Characterization of MAD2B and other mitotic spindle checkpoint genes

31 March 2020

1 reference

Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers.

31 March 2020

1 reference

Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer

31 March 2020

1 reference

Loss of pRB causes centromere dysfunction and chromosomal instability

31 March 2020

1 reference

pRB, a tumor suppressor with a stabilizing presence

31 March 2020

1 reference

Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.

31 March 2020

1 reference

Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome

31 March 2020

1 reference

Trisomy represses Apc Min -mediated tumours in mouse models of Down’s syndrome

31 March 2020

1 reference

Risks of leukaemia and solid tumours in individuals with Down's syndrome.

31 March 2020

1 reference

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

31 March 2020

1 reference

Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes

31 March 2020

1 reference

Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia

31 March 2020

1 reference

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

31 March 2020

1 reference

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

31 March 2020

1 reference

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

31 March 2020

1 reference

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.

31 March 2020

1 reference

Karyotypic determinants of chromosome instability in aneuploid budding yeast

31 March 2020

1 reference

Aneuploidy drives genomic instability in yeast

31 March 2020

1 reference

Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor

31 March 2020

1 reference

Aneuploidy and isochromosome formation in drug-resistant Candida albicans

31 March 2020

1 reference

Chromosomal duplication is a transient evolutionary solution to stress.

31 March 2020

1 reference

Targeting the adaptability of heterogeneous aneuploids

31 March 2020

1 reference

Signalling dynamics in the spindle checkpoint response

31 March 2020

1 reference

Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells

31 March 2020

1 reference

Does aneuploidy cause cancer?

31 March 2020

1 reference

Statistical analysis of nondisjunction assays in Drosophila

31 March 2020

1 reference

Nondisjunction of the X chromosomes in females ofDrosophila hydei

31 March 2020

1 reference

Recombination and nondisjunction in humans and flies

31 March 2020

1 reference

Distribution of aneuploidy in human gametes: comparison between human sperm and oocytes.

31 March 2020

1 reference

The frequency of aneuploidy among individual chromosomes in 6,821 human sperm chromosome complements

31 March 2020

1 reference

Aneuploidy in human spermatozoa.

31 March 2020

1 reference

The occurrence of aneuploidy in human: lessons from the cytogenetic studies of human oocytes

31 March 2020

1 reference

Gender effects on the incidence of aneuploidy in mammalian germ cells

31 March 2020

1 reference

Whole-chromosome aneuploidy analysis in human oocytes: focus on comparative genomic hybridization

31 March 2020

1 reference

Human aneuploidy: mechanisms and new insights into an age-old problem

31 March 2020

1 reference

Inhibition of transcription results in accumulation of Wt p53 followed by delayed outburst of p53-inducible proteins: p53 as a sensor of transcriptional integrity.

31 March 2020

1 reference

12 December 2020

Human aneuploidy: incidence, origin, and etiology

1 reference

12 December 2020

Characterization of Schizosaccharomyces pombe minichromosome deletion derivatives and a functional allocation of their centromere

1 reference

12 December 2020

Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model

1 reference

12 December 2020

Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae.

1 reference

12 December 2020

The release of labeled amino acids from the proteins of rat liver slices

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12 December 2020

Identifiers

DOI

10.1038/NRM4025

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Dimensions Publication ID

2 August 2017

1003767537

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