(Q34498995)

2 August 2017

title

PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2. (English)

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2 August 2017

2

Michelle L James

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2 August 2017

Timothy H Witney

1

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2 August 2017

Bin Shen

3

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2 August 2017

Edwin Chang

4

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2 August 2017

Christoph Pohling

5

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2 August 2017

Natasha Arksey

6

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2 August 2017

Aileen Hoehne

7

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2 August 2017

Adam Shuhendler

8

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2 August 2017

Jun-Hyung Park

9

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2 August 2017

Deepika Bodapati

10

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2 August 2017

Judith Weber

11

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2 August 2017

Gayatri Gowrishankar

12

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2 August 2017

Jianghong Rao

13

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2 August 2017

Frederick T Chin

14

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2 August 2017

Sanjiv Sam Gambhir

15

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2 August 2017

language of work or name

English

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publication date

1 October 2015

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Science Translational Medicine

2 August 2017

published in

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2 August 2017

volume

7

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2 August 2017

issue

310

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2 August 2017

page(s)

310ra169

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Regulation of cancer cell metabolism

2 August 2017

cites work

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PKM2, a Central Point of Regulation in Cancer Metabolism

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Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

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Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

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Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer

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Regulation of rat liver pyruvate kinase. The effect of preincubation, pH, copper ions, fructose 1,6-diphosphate and dietary changes on enzyme activity

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

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Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

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PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

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Patient-derived xenograft models: an emerging platform for translational cancer research

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Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

21 January 2018

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Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery

21 January 2018

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

21 January 2018

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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

21 January 2018

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Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

21 January 2018

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

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No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

21 January 2018

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 January 2018

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Multimolecular forms of pyruvate kinase from rat and other mammalian tissues. I. Electrophoretic studies

21 January 2018

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A Systematic Comparison of 18F-C-SNAT to Established Radiotracer Imaging Agents for the Detection of Tumor Response to Treatment

21 January 2018

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Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

21 January 2018

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Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC- transporter using positron emission tomography in patients with non-small cell lung or breast cancer

21 January 2018

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Identification of small molecule inhibitors of pyruvate kinase M2

21 January 2018

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2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAC6117

Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAC6117

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

21 January 2018

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New positron emission tomography (PET) radioligand for imaging σ-1 receptors in living subjects

21 January 2018

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10.1126/SCITRANSLMED.AAC6117

21 January 2018

Identifiers

DOI

1 reference

2 August 2017

1 reference