(Q34508675)

26758213

2 August 2017

title

Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia (English)

1 reference

2 August 2017

0 references

8

1 reference

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10 June 2020

Amanda K Fakira

9

1 reference

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10 June 2020

J Javier Meana

18

1 reference

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10 June 2020

Diomedes E Logothetis

17

object named as

Diomedes E Logothetis

1 reference

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10 June 2020

author name string

José L Moreno

1

1 reference

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10 June 2020

Patricia Miranda-Azpiazu

2

1 reference

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10 June 2020

Aintzane García-Bea

3

1 reference

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10 June 2020

Jason Younkin

4

1 reference

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10 June 2020

Meng Cui

5

1 reference

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10 June 2020

Alexey Kozlenkov

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Ariel Ben-Ezra

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Lia Baki

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Yongchao Ge

11

1 reference

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10 June 2020

Anastasios Georgakopoulos

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

José A Morón

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Graeme Milligan

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Juan F López-Giménez

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Nikolaos K Robakis

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Javier González-Maeso

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

publication date

12 January 2016

1 reference

2 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

410

1 reference

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10 June 2020

page(s)

ra5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

The experimental power of FR900359 to study Gq-regulated biological processes

10 June 2020

cites work

1 reference

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Structural insights into µ-opioid receptor activation

7 July 2018

1 reference

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Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment

7 July 2018

1 reference

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Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.

7 July 2018

1 reference

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Computational approaches for modeling GPCR dimerization

7 July 2018

1 reference

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Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator

7 July 2018

1 reference

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Preclinical models of antipsychotic drug action

7 July 2018

1 reference

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A long-term, phase 2, multicenter, randomized, open-label, comparative safety study of pomaglumetad methionil (LY2140023 monohydrate) versus atypical antipsychotic standard of care in patients with schizophrenia

7 July 2018

1 reference

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Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state

7 July 2018

1 reference

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The dynamic process of β(2)-adrenergic receptor activation

7 July 2018

1 reference

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Animal models of serotonergic psychedelics

7 July 2018

1 reference

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Dysregulated 5-HT(2A) receptor binding in postmortem frontal cortex of schizophrenic subjects

7 July 2018

1 reference

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Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function

7 July 2018

1 reference

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Restructuring G-protein- coupled receptor activation

7 July 2018

1 reference

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Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling

7 July 2018

1 reference

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Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1.

7 July 2018

1 reference

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HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.

7 July 2018

1 reference

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Clinical development of pomaglumetad methionil: a non-dopaminergic treatment for schizophrenia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

Structure of the human κ-opioid receptor in complex with JDTic

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

Crystal structure of the β2 adrenergic receptor-Gs protein complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

GPCR oligomers in pharmacology and signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

7 July 2018

1 reference

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Group II metabotropic glutamate receptors and schizophrenia

7 July 2018

1 reference

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Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.

7 July 2018

1 reference

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Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration

7 July 2018

1 reference

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Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2.

7 July 2018

1 reference

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The structure and function of G-protein-coupled receptors

7 July 2018

1 reference

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Extinction of morphine-dependent conditioned behavior is associated with increased phosphorylation of the GluR1 subunit of AMPA receptors at hippocampal synapses

7 July 2018

1 reference

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G protein activation by the leukotriene B4 receptor dimer. Evidence for an absence of trans-activation.

7 July 2018

1 reference

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Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

7 July 2018

1 reference

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Comparative protein structure modeling using Modeller

7 July 2018

1 reference

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Identification of a serotonin/glutamate receptor complex implicated in psychosis

7 July 2018

1 reference

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Heterotrimeric G protein activation by G-protein-coupled receptors

7 July 2018

1 reference

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Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer

7 July 2018

1 reference

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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

7 July 2018

1 reference

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A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

7 July 2018

1 reference

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Transducin activation by nanoscale lipid bilayers containing one and two rhodopsins

7 July 2018

1 reference

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Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior

7 July 2018

1 reference

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The alpha1b-adrenoceptor exists as a higher-order oligomer: effective oligomerization is required for receptor maturation, surface delivery, and function

7 July 2018

1 reference

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Cerulean, Venus, and VenusY67C FRET reference standards

7 July 2018

1 reference

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

7 July 2018

1 reference

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Visualization of molecular interactions by fluorescence complementation

7 July 2018

1 reference

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UCSF Chimera--a visualization system for exploratory research and analysis

7 July 2018

1 reference

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Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.

7 July 2018

1 reference

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Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex

7 July 2018

1 reference

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Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation

7 July 2018

1 reference

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Ligand-induced signal transduction within heterodimeric GABA(B) receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors

7 July 2018

1 reference

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A major role for thalamocortical afferents in serotonergic hallucinogen receptor function in the rat neocortex

7 July 2018

1 reference

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Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex

7 July 2018

1 reference

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Measurement of intracellular calcium

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation

7 July 2018

1 reference

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Adenosine A1 receptor-mediated activation of phospholipase C in cultured astrocytes depends on the level of receptor expression.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

VMD: visual molecular dynamics

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

Comparative protein modelling by satisfaction of spatial restraints

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4819166

Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins

7 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0467

Cooperative conformational changes in a G-protein-coupled receptor dimer, the leukotriene B(4) receptor BLT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0467

Activation of PLC-delta1 by Gi/o-coupled receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0467

Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0467

A multicenter, inpatient, phase 2, double-blind, placebo-controlled dose-ranging study of LY2140023 monohydrate in patients with DSM-IV schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0467

Modeling dimerizations of transmembrane proteins using Brownian dynamics simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0467

Reduced platelet G protein-coupled receptor kinase 2 in major depressive disorder: antidepressant treatment-induced upregulation of GRK2 protein discriminates between responder and non-responder patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0467

Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0467

Exploratory analysis for a targeted patient population responsive to the metabotropic glutamate 2/3 receptor agonist pomaglumetad methionil in schizophrenia

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26758213

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Suramin analogues as subtype-selective G protein inhibitors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26758213

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCISIGNAL.AAB0467

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26758213%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

26758213

1 reference