(Q34527281)

2 August 2017

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title

Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer (English)

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2 August 2017

1

Harald von Boehmer

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2 August 2017

Carolin Daniel

2

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2 August 2017

1 January 2013

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Nature Reviews Drug Discovery

2 August 2017

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2 August 2017

12

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2 August 2017

51-63

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2 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrd3683

2 August 2017

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cites work

T cell tolerance by clonal elimination in the thymus

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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

31 March 2020

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31 March 2020

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

31 March 2020

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

31 March 2020

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A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens

31 March 2020

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Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype

31 March 2020

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Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

31 March 2020

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Antigen-driven bystander suppression after oral administration of antigens

31 March 2020

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Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression

31 March 2020

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Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

31 March 2020

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Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

31 March 2020

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Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

31 March 2020

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FOXP3 acts as a rheostat of the immune response

31 March 2020

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Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases

31 March 2020

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Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21.

31 March 2020

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Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

31 March 2020

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An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction

31 March 2020

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Structural basis of T cell recognition

31 March 2020

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Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor

31 March 2020

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Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

31 March 2020

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Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

31 March 2020

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T cell receptor recognition of self and foreign antigens in the induction of autoimmunity

31 March 2020

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Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen season

31 March 2020

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Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease.

31 March 2020

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Human CD4+CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production

31 March 2020

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Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals

31 March 2020

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Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells.

31 March 2020

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Regulatory T cells, tumour immunity and immunotherapy

31 March 2020

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Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells

31 March 2020

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Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation

31 March 2020

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The secret ally: immunostimulation by anticancer drugs

31 March 2020

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Cancer immunotherapy--revisited

31 March 2020

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The anticancer immune response: indispensable for therapeutic success?

31 March 2020

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Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.

31 March 2020

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TGF-beta: a master of all T cell trades

31 March 2020

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DNA methylation controls Foxp3 gene expression

31 March 2020

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Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

31 March 2020

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Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict

31 March 2020

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Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome

31 March 2020

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Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.

31 March 2020

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Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

31 March 2020

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Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

31 March 2020

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CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

31 March 2020

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Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

31 March 2020

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Enhancement of antigen-specific Treg vaccination in vivo

31 March 2020

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In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

31 March 2020

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Interleukin-2 and regulatory T cells in graft-versus-host disease

31 March 2020

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Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis

31 March 2020

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Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease

31 March 2020

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Origin of regulatory T cells with known specificity for antigen

31 March 2020

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

31 March 2020

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In vivo instruction of suppressor commitment in naive T cells

31 March 2020

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Antigen-specific induction of regulatory T cells in vivo and in vitro

31 March 2020

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Inducing and expanding regulatory T cell populations by foreign antigen

31 March 2020

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Regulatory lymphocytes and intestinal inflammation.

31 March 2020

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TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

31 March 2020

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Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope

31 March 2020

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Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1.

31 March 2020

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In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro

31 March 2020

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Stability of the regulatory T cell lineage in vivo.

31 March 2020

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Mechanisms for T cell receptor triggering

31 March 2020

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PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors

31 March 2020

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T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

31 March 2020

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The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

31 March 2020

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Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

31 March 2020

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Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3

31 March 2020

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Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.

31 March 2020

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Dissolving polymer microneedle patches for influenza vaccination

31 March 2020

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Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects

31 March 2020

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Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo

31 March 2020

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

31 March 2020

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Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

31 March 2020

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TOR, a central controller of cell growth

31 March 2020

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Infectious tolerance via the consumption of essential amino acids and mTOR signaling

31 March 2020

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Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

31 March 2020

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The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism

31 March 2020

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

31 March 2020

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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

31 March 2020

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Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

31 March 2020

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Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

31 March 2020

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Rapamycin passes the torch: a new generation of mTOR inhibitors

31 March 2020

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The cunning little vixen: Foxo and the cycle of life and death

31 March 2020

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Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases

31 March 2020

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Regulatory T cells: mechanisms of differentiation and function

31 March 2020

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Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice

31 March 2020

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

31 March 2020

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The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.

31 March 2020

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The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

31 March 2020

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Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.

31 March 2020

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The immune modulator FTY720 targets sphingosine 1-phosphate receptors

31 March 2020

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Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer

31 March 2020

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

31 March 2020

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FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.

31 March 2020

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The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity

31 March 2020

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S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate

31 March 2020

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Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

31 March 2020

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KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts

31 March 2020

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Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

31 March 2020

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Sphingosine 1-phosphate analogs as receptor antagonists

31 March 2020

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Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.

31 March 2020

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Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

31 March 2020

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Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules

31 March 2020

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"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets

31 March 2020

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MicroRNA control in the immune system: basic principles

31 March 2020

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A role for Dicer in immune regulation

31 March 2020

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T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer

31 March 2020

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The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease

31 March 2020

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Dicer-dependent microRNA pathway safeguards regulatory T cell function

31 March 2020

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Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein

31 March 2020

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Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.

31 March 2020

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IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

31 March 2020

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Nonredundant roles for Stat5a/b in directly regulating Foxp3

31 March 2020

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Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses

31 March 2020

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MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2.

31 March 2020

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NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

31 March 2020

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An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

31 March 2020

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miR-181a is an intrinsic modulator of T cell sensitivity and selection

31 March 2020

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Control of regulatory T cell lineage commitment and maintenance

31 March 2020

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The blockade of immune checkpoints in cancer immunotherapy

31 March 2020

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Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation

31 March 2020

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Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

31 March 2020

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Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function

31 March 2020

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Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance.

31 March 2020

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Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

31 March 2020

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Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses

31 March 2020

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CD4+Foxp3+ regulatory T-cell impairment by paclitaxel is independent of toll-like receptor 4.

31 March 2020

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Imatinib mesylate inhibits CD4+ CD25+ regulatory T cell activity and enhances active immunotherapy against BCR-ABL- tumors

31 March 2020

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A decrease of regulatory T cells correlates with overall survival after sunitinib-based antiangiogenic therapy in metastatic renal cancer patients

31 March 2020

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Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells

31 March 2020

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Role of STAT3 in CD4+CD25+FOXP3+ regulatory lymphocyte generation: implications in graft-versus-host disease and antitumor immunity

31 March 2020

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Combining immunotherapy and targeted therapies in cancer treatment

31 March 2020

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Checkpoint blockade in cancer immunotherapy

31 March 2020

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Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies

31 March 2020

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Enhancement of antitumor immunity by CTLA-4 blockade

31 March 2020

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Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

31 March 2020

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Frequency of Circulating Tregs with Demethylated FOXP3 Intron 1 in Melanoma Patients Receiving Tumor Vaccines and Potentially Treg-Depleting Agents

31 March 2020

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Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients

31 March 2020

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IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity

31 March 2020

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Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells

31 March 2020

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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

31 March 2020

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Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer

31 March 2020

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A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.

31 March 2020

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Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor

31 March 2020

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Effects of insulin in relatives of patients with type 1 diabetes mellitus

31 March 2020

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Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes

31 March 2020

1 reference

Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial

31 March 2020

1 reference

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

31 March 2020

1 reference

Oral immunotherapy for treatment of egg allergy in children

31 March 2020

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Mucosal insulin vaccination for type 1 diabetes prevention

31 March 2020

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Immunotherapy of type 1 diabetes: where are we and where should we be going?

31 March 2020

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CD4+CD25high regulatory cells in human peripheral blood

31 March 2020

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Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood

31 March 2020

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Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

31 March 2020

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Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

31 March 2020

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Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

31 March 2020

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Control of autoimmunity by naturally arising regulatory CD4+ T cells

31 March 2020

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Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

31 March 2020

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Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3

31 March 2020

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Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

31 March 2020

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Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor

31 March 2020

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Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4(+)CD25(-) cells

31 March 2020

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The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

31 March 2020

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Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

31 March 2020

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Human regulatory T cells in autoimmune diseases

31 March 2020

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Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.

31 March 2020

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FOXP3+ regulatory T cells in the human immune system

31 March 2020

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Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

31 March 2020

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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

31 March 2020

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Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity

31 March 2020

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A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

31 March 2020

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Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice

31 March 2020

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Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice

31 March 2020

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Prediction and pathogenesis in type 1 diabetes.

31 March 2020

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Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse

31 March 2020

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A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes

31 March 2020

1 reference

Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice

31 March 2020

1 reference

Human-Hemato-Lymphoid-System Mice: Opportunities and Challenges

31 March 2020

1 reference

Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes

31 March 2020

1 reference

High diversity of the immune repertoire in humanized NOD.SCID.gamma c-/- mice

31 March 2020

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Humanized mice in translational biomedical research

31 March 2020

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STAT3: a target to enhance antitumor immune response

31 March 2020

1 reference

12 December 2020

RAD 001 (everolimus) prevents mTOR and Akt late re-activation in response to imatinib in chronic myeloid leukemia

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12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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12 December 2020

Smad regulation in TGF-beta signal transduction

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12 December 2020

Increase of regulatory T cells in the peripheral blood of cancer patients.

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12 December 2020

Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3683

1 reference

2 August 2017

1 reference

PubMed ID

23274471