(Q34545220)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27869826%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

title

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27869826%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

author

Joachim Weischenfeldt

1

1 reference

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27 March 2020

Stefan M. Pfister

19

1 reference

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27 March 2020

Åslaug Helland

27

1 reference

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27 March 2020

Claudia R Ball

28

1 reference

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27 March 2020

Rocio Sotillo

30

1 reference

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27 March 2020

Jan Korbel

32

1 reference

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27 March 2020

Alexandros P Drainas

3

1 reference

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27 March 2020

Balca R Mardin

4

1 reference

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27 March 2020

Sebastian M Waszak

7

1 reference

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27 March 2020

Benjamin Raeder

10

1 reference

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27 March 2020

Serap Erkek

12

1 reference

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27 March 2020

Hermann Brenner

14

1 reference

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27 March 2020

Sebastian M Dieter

16

1 reference

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27 March 2020

Thomas Zichner

24

1 reference

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27 March 2020

Martin Peifer

26

1 reference

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27 March 2020

Martin Jechlinger

29

1 reference

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27 March 2020

15

Odd Terje Brustugun

1 reference

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27 March 2020

17

Paul A Northcott

1 reference

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27 March 2020

23

Wilko Weichert

1 reference

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27 March 2020

18

Iver Petersen

1 reference

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27 March 2020

9

Ann Rita Halvorsen

1 reference

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27 March 2020

author name string

Taronish Dubash

2

1 reference

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27 March 2020

Yuanyuan Chen

5

1 reference

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27 March 2020

Adrian M Stütz

6

1 reference

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27 March 2020

Graziella Bosco

8

1 reference

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27 March 2020

Theocharis Efthymiopoulos

11

1 reference

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27 March 2020

Christine Siegl

13

1 reference

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27 March 2020

Martin Schneider

20

1 reference

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27 March 2020

Steinar K Solberg

21

1 reference

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27 March 2020

Erik Thunissen

22

1 reference

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27 March 2020

Roman Thomas

25

1 reference

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27 March 2020

Hanno Glimm

31

1 reference

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27 March 2020

language of work or name

English

0 references

publication date

21 November 2016

1 reference

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27 March 2020

1 reference

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27 March 2020

volume

49

1 reference

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27 March 2020

issue

1

1 reference

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27 March 2020

page(s)

65-74

1 reference

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https://scigraph.springernature.com/pub.10.1038/ng.3722

27 March 2020

exact match

0 references

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7 July 2018

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7 July 2018

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7 July 2018

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Structural and functional diversity of Topologically Associating Domains

7 July 2018

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7 July 2018

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Recurrent somatic mutations in regulatory regions of human cancer genomes

7 July 2018

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7 July 2018

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Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions

7 July 2018

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Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation

7 July 2018

1 reference

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CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation

7 July 2018

1 reference

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IGF2 signaling and regulation in cancer.

7 July 2018

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Integrative analysis of 111 reference human epigenomes

7 July 2018

1 reference

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The landscape and therapeutic relevance of cancer-associated transcript fusions.

7 July 2018

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A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping

7 July 2018

1 reference

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Proliferation and migration of hepatoblastoma cells are mediated by IRS-4 via PI3K/Akt pathways.

7 July 2018

1 reference

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Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

7 July 2018

1 reference

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Genome-wide analysis of noncoding regulatory mutations in cancer

7 July 2018

1 reference

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Mapping the Shh long-range regulatory domain

7 July 2018

1 reference

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The somatic genomic landscape of chromophobe renal cell carcinoma

7 July 2018

1 reference

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When deletions gain functions: commandeering epigenetic mechanisms

7 July 2018

1 reference

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Genomics of uterine leiomyomas: insights from high-throughput sequencing

7 July 2018

1 reference

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Comprehensive molecular profiling of lung adenocarcinoma

7 July 2018

1 reference

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Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

7 July 2018

1 reference

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Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

7 July 2018

1 reference

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A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia

7 July 2018

1 reference

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Identification of genomic alterations in oesophageal squamous cell cancer

7 July 2018

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Functional and topological characteristics of mammalian regulatory domains.

7 July 2018

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Discovery and saturation analysis of cancer genes across 21 tumour types

7 July 2018

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Topology of mammalian developmental enhancers and their regulatory landscapes

7 July 2018

1 reference

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A high-resolution map of the three-dimensional chromatin interactome in human cells

7 July 2018

1 reference

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Mutational landscape and significance across 12 major cancer types

7 July 2018

1 reference

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Super-enhancers in the control of cell identity and disease

7 July 2018

1 reference

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Pan-cancer patterns of somatic copy number alteration

7 July 2018

1 reference

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Emerging landscape of oncogenic signatures across human cancers

7 July 2018

1 reference

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Effect of IRS4 levels on PI 3-kinase signalling

7 July 2018

1 reference

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Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence.

7 July 2018

1 reference

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Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Punctuated evolution of prostate cancer genomes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Master transcription factors and mediator establish super-enhancers at key cell identity genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Genome-wide chromatin state transitions associated with developmental and environmental cues

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

DELLY: structural variant discovery by integrated paired-end and split-read analysis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Comprehensive genomic characterization of squamous cell lung cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

The long-range interaction landscape of gene promoters

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

An integrated encyclopedia of DNA elements in the human genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

4C technology: protocols and data analysis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Dissecting the genomic complexity underlying medulloblastoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Comprehensive molecular characterization of human colon and rectal cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

A map of the cis-regulatory sequences in the mouse genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Spatial partitioning of the regulatory landscape of the X-inactivation centre

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Topological domains in mammalian genomes identified by analysis of chromatin interactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Mechanisms of FGFR-mediated carcinogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Mapping and analysis of chromatin state dynamics in nine human cell types

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Genomic inflation factors under polygenic inheritance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Transcriptional enhancers in animal development and evolution

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Independent filtering increases detection power for high-throughput experiments

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

The landscape of somatic copy-number alteration across human cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Signatures of mutation and selection in the cancer genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

BEDTools: a flexible suite of utilities for comparing genomic features

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Complex landscapes of somatic rearrangement in human breast cancer genomes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

A comprehensive catalogue of somatic mutations from a human cancer genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Chromosomal translocations in cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Paired-end mapping reveals extensive structural variation in the human genome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

PLINK: a tool set for whole-genome association and population-based linkage analyses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Primer3Plus, an enhanced web interface to Primer3

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Principal components analysis corrects for stratification in genome-wide association studies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Decreasing IRS-2 expression in pancreatic β-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

An enhancer deletion affects both H19 and Igf2 expression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Non-coding recurrent mutations in chronic lymphocytic leukaemia

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Enhancer loops appear stable during development and are associated with paused polymerase.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: from fixation to computation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791882

Population Variation and Genetic Control of Modular Chromatin Architecture in Humans

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27869826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Distinct types of tumor-initiating cells form human colon cancer tumors and metastases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27869826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NG.3722

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27869826%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27869826%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference