(Q34567724)

3 August 2017

title

Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling (English)

1 reference

3 August 2017

0 references

Zbyszek Darzynkiewicz

7

object named as

Zbigniew Darzynkiewicz

1 reference

3 August 2017

H Dorota Halicka

1

1 reference

3 August 2017

Hong Zhao

2

1 reference

3 August 2017

Jiangwei Li

3

1 reference

3 August 2017

Yong-Syu Lee

4

1 reference

3 August 2017

Tze-Chen Hsieh

5

1 reference

3 August 2017

Joseph M Wu

6

1 reference

3 August 2017

language of work or name

1 reference

1 December 2012

1 reference

3 August 2017

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3 August 2017

volume

4

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3 August 2017

issue

12

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3 August 2017

page(s)

952-965

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DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis

3 August 2017

cites work

1 reference

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Berberine inhibits mouse insulin gene promoter through activation of AMP activated protein kinase and may exert beneficial effect on pancreatic β-cell

7 July 2018

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7 July 2018

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7 July 2018

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mTor as a potential target for the prevention and treatment of hepatocellular carcinoma

7 July 2018

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Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence

7 July 2018

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The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3.

7 July 2018

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Colorectal cancer chemoprevention by trans-resveratrol

7 July 2018

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The journey of resveratrol from yeast to human

7 July 2018

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The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses

7 July 2018

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Control of stability of cyclin D1 by quinone reductase 2 in CWR22Rv1 prostate cancer cells

7 July 2018

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1,25-dihydroxyvitamin D3 treatment delays cellular aging in human mesenchymal stem cells while maintaining their multipotent capacity

7 July 2018

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Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice

7 July 2018

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Target of rapamycin (TOR) in nutrient signaling and growth control

7 July 2018

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Rapamycin: killing two birds with one stone

7 July 2018

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Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

7 July 2018

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Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection

7 July 2018

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The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

7 July 2018

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Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling

7 July 2018

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Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells.

7 July 2018

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Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2.

7 July 2018

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The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases

7 July 2018

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Metformin as a geroprotector.

7 July 2018

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Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage

7 July 2018

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Berberine: a potential multipotent natural product to combat Alzheimer's disease.

7 July 2018

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Metformin abolishes increased tumor (18)F-2-fluoro-2-deoxy-D-glucose uptake associated with a high energy diet

7 July 2018

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Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals

7 July 2018

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Error-prone nonhomologous end joining repair operates in human pluripotent stem cells during late G2.

7 July 2018

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Mutations in the BRCT binding site of BRCA1 result in hyper-recombination

7 July 2018

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Metformin as an antitumor agent in cancer prevention and treatment

7 July 2018

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Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD(+) level, SIRT1 activity and replicative lifespan of human Hs68 cells

7 July 2018

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Relieving autophagy and 4EBP1 from rapamycin resistance

7 July 2018

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Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells

7 July 2018

1 reference

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Gerosuppressant metformin: less is more

7 July 2018

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Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis

7 July 2018

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Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model

7 July 2018

1 reference

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Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence

7 July 2018

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If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

7 July 2018

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Recent developments in the use of γ-H2AX as a quantitative DNA double-strand break biomarker

7 July 2018

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The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan.

7 July 2018

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p53 governs telomere regulation feedback too, via TRF2.

7 July 2018

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DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

7 July 2018

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Metformin and sex: Why suppression of aging may be harmful to young male mice

7 July 2018

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Glycolytic inhibition as a strategy for developing calorie restriction mimetics

7 July 2018

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7 July 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

7 July 2018

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mTOR and its link to the picture of Dorian Gray - re-activation of mTOR promotes aging

7 July 2018

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Nek6 overexpression antagonizes p53-induced senescence in human cancer cells

7 July 2018

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Metformin for aging and cancer prevention

7 July 2018

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Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs

7 July 2018

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Insights into Cdc13 dependent telomere length regulation

7 July 2018

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TP53 and MTOR crosstalk to regulate cellular senescence

7 July 2018

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Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program

7 July 2018

1 reference

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S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

7 July 2018

1 reference

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LIM-domain proteins TRIP6 and LPP associate with shelterin to mediate telomere protection

7 July 2018

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Another "Janus paradox" of p53: induction of cell senescence versus quiescence

7 July 2018

1 reference

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Calorie restriction: what recent results suggest for the future of ageing research

7 July 2018

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Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops

7 July 2018

1 reference

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Endogenous oxidative stress prevents telomerase-dependent immortalization of human endothelial cells.

7 July 2018

1 reference

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Rapamycin extends maximal lifespan in cancer-prone mice

7 July 2018

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The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging

7 July 2018

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Vitamin D: considerations in the continued development as an agent for cancer prevention and therapy

7 July 2018

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Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase

7 July 2018

1 reference

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The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1.

7 July 2018

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mTOR's role in ageing: protein synthesis or autophagy?

7 July 2018

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Growth and aging: a common molecular mechanism

7 July 2018

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Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans).

7 July 2018

1 reference

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When a theory of aging ages badly.

7 July 2018

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7 July 2018

2 references

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7 July 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong?

27 October 2018

1 reference

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Molecular mechanisms of mTOR-mediated translational control

7 July 2018

1 reference

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Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

DNA replication stress, genome instability and aging

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Program-like aging and mitochondria: instead of random damage by free radicals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Vitamin D and aging: old concepts and new insights

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species.

7 July 2018

1 reference

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TOR signaling in growth and metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Formation of an energized inner membrane in mitochondria with a gamma-deficient F1-ATPase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Aspirin reduces endothelial cell senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Mitochondria, telomeres and cell senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Extension of murine life span by overexpression of catalase targeted to mitochondria

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Artemis links ATM to double strand break rejoining

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Upstream and downstream of mTOR

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

DNA damage responses to oxidative stress

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Interventions with antioxidants and nutrients in relation to oxidative DNA damage and repair

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

DNA end joining becomes less efficient and more error-prone during cellular senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Laser-scanning cytometry: A new instrumentation with many applications

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

7 July 2018

Oxidative Decay of DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Interaction of rhodamine 123 with living cells studied by flow cytometry.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Increased mitochondrial uptake of rhodamine 123 during lymphocyte stimulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Lymphocyte stimulation: a rapid multiparameter analysis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Running m(o)TOR with the brakes on leads to catastrophe at mitosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Genotoxic stress-mediated cell cycle activities for the decision of cellular fate.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Accelerated aging in the tumor microenvironment: connecting aging, inflammation and cancer metabolism with personalized medicine

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Inhibition of mTORC1 by RAD001 (everolimus) potentiates the effects of 1,25-dihydroxyvitamin D(3) to induce growth arrest and differentiation of AML cells in vitro and in vivo

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Effect of aspirin on high glucose-induced senescence of endothelial cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

TOR-driven aging: speeding car without brakes

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Protective effect of hyaluronate on oxidative DNA damage in WI-38 and A549 cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Low-dose aspirin prevents age-related endothelial dysfunction in a mouse model of physiological aging.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

The role of intracellular peroxide levels on the development and maintenance of telomere-dependent senescence.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Inhibition of chemical carcinogenesis by berberine in rats and mice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615161

Effect of Phytohaemagglutinin on Synthesis of ‘Rapidly-labelled’ Ribonucleic Acid in Human Lymphocytes

27 October 2018

1 reference

12 December 2020

Berberine derivatives as cationic fluorescent probes for the investigation of the energized state of mitochondria

1 reference

12 December 2020

Will an aspirin a day keep cancer away?

1 reference

12 December 2020

Effect of berberine on bone mineral density in SAMP6 as a senile osteoporosis model

1 reference

12 December 2020

Mitochondrial dysfunction leads to telomere attrition and genomic instability

1 reference

12 December 2020

Identifiers

DOI

10.18632/AGING.100521

0 references

PMC publication ID

3615161

1 reference

3 August 2017

1 reference