(Q34568964)

3 August 2017

1 reference

title

Targeting apoptosis in cancer chemotherapy (English)

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3 August 2017

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Guy Makin

1

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language of work or name

English

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publication date

1 February 2002

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Expert Opinion on Therapeutic Targets

3 August 2017

published in

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3 August 2017

volume

6

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3 August 2017

issue

1

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3 August 2017

page(s)

73-84

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Apoptosis: cell death in tissue regulation

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

The biochemistry of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Induction of apoptosis by cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Social controls on cell survival and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Apoptosis and chemotherapy resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

The Bcl-2 protein family: arbiters of cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

The apoptosome: heart and soul of the cell death machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Apoptotic pathways: paper wraps stone blunts scissors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Role of BAX in the apoptotic response to anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Epigenetic determinants of resistance to etoposide regulation of Bcl-X(L) and Bax by tumor microenvironmental factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Mammalian MAP kinase signalling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Ten years of protein kinase B signalling: a hard Akt to follow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

AKT plays a central role in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Targeting ceramide metabolism--a strategy for overcoming drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Regulation of ceramide production and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Taxol-induced ceramide generation and apoptosis in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Apoptosis and sphingomyelin hydrolysis. The flip side

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

The Survivin saga goes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Cancer gene therapy using a survivin mutant adenovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

The potential of TRAIL for cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Retinoid-induced apoptosis in normal and neoplastic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Retinoic acid receptors alpha and gamma mediate the induction of "tissue" transglutaminase activity and apoptosis in human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

Blocking oncogenic Ras signaling for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.1.73

21 January 2018

Identifiers

DOI

10.1517/14728222.6.1.73

1 reference

3 August 2017

1 reference