(Q34572090)

3 August 2017

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title

Cancer gene therapy: fringe or cutting edge? (English)

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3 August 2017

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McCormick F

1

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3 August 2017

language of work or name

English

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publication date

1 November 2001

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3 August 2017

Nature Reviews Cancer

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3 August 2017

1

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3 August 2017

2

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3 August 2017

130-141

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https://scigraph.springernature.com/pub.10.1038/35101008

3 August 2017

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cites work

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7 January 2021

RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice

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7 January 2021

Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells

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7 January 2021

MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells

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7 January 2021

Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells

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7 January 2021

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

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7 January 2021

Growth retardation and tumour inhibition by BRCA1.

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7 January 2021

Surfing the p53 network

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7 January 2021

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

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7 January 2021

Mutations in the APC tumour suppressor gene cause chromosomal instability

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7 January 2021

The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin.

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7 January 2021

Induction of the growth inhibitor IGF-binding protein 3 by p53

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7 January 2021

Tumor necrosis factor as an antineoplastic agent: pitfalls and promises

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7 January 2021

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

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7 January 2021

Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer

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7 January 2021

Essential role for oncogenic Ras in tumour maintenance

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7 January 2021

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

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7 January 2021

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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7 January 2021

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

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7 January 2021

The EGF receptor family as targets for cancer therapy

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7 January 2021

Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine

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7 January 2021

Antiangiogenic gene therapy for cancer via systemic administration of adenoviral vectors expressing secretable endostatin

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7 January 2021

Adenovirus-mediated delivery of antiangiogenic genes as an antitumor approach

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7 January 2021

A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme.

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7 January 2021

Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses

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7 January 2021

Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies

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7 January 2021

Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions

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7 January 2021

Gene therapy for hepatocellular carcinoma using two recombinant adenovirus vectors with alpha-fetoprotein promoter and Cre/lox P system

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7 January 2021

Replicating viruses as selective cancer therapeutics

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7 January 2021

Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

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7 January 2021

Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial

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7 January 2021

Treatment of experimental subcutaneous human melanoma with a replication-restricted herpes simplex virus mutant

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7 January 2021

Intralesional injection of herpes simplex virus 1716 in metastatic melanoma

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7 January 2021

Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma

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7 January 2021

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

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7 January 2021

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

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7 January 2021

Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway?

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7 January 2021

Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: intratumoral spread and distribution effects

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7 January 2021

p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection

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7 January 2021

Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).

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7 January 2021

Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer

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7 January 2021

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

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7 January 2021

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

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7 January 2021

A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

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7 January 2021

Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein

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7 January 2021

Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy

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7 January 2021

Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway

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7 January 2021

Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen.

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7 January 2021

A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy

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7 January 2021

Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer

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7 January 2021

Virus-mediated killing of cells that lack p53 activity

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7 January 2021

Replication-selective virotherapy for cancer: Biological principles, risk management and future directions

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7 January 2021

Blood clearance rates of adenovirus type 5 in mice

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7 January 2021

The coxsackievirus-adenovirus receptor protein as a cell adhesion molecule in the developing mouse brain

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7 January 2021

Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers

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7 January 2021

Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR

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7 January 2021

Uptake of adenoviral vectors via fibroblast growth factor receptors involves intracellular pathways that differ from the targeting ligand

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7 January 2021

Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vector

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7 January 2021

Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies.

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7 January 2021

Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses

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7 January 2021

Pre-existent adenovirus antibody inhibits systemic toxicity and antitumor activity of CN706 in the nude mouse LNCaP xenograft model: implications and proposals for human therapy

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7 January 2021

New-age drug meets resistance

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7 January 2021

The p53-independent tumoricidal activity of an adenoviral vector encoding a p27-p16 fusion tumor suppressor gene

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7 January 2021

Adenovirus-mediated retinoblastoma gene therapy suppresses spontaneous pituitary melanotroph tumors in Rb+/- mice

1 reference

7 January 2021

Adenovirus-mediated wild-type p53 gene expression radiosensitizes non-small cell lung cancer cells but not normal lung fibroblasts

1 reference

7 January 2021

Adenovirus-mediated transduction of ribozymes abrogates HER-2/neu and pleiotrophin expression and inhibits tumor cell proliferation

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7 January 2021

Specific down-regulation of HER-2/neu mediated by a chimeric U6 hammerhead ribozyme results in growth inhibition of human ovarian carcinoma.

1 reference

7 January 2021

Adenovirus-mediated ribozyme targeting of HER-2/neu inhibits in vivo growth of breast cancer cells

1 reference

7 January 2021

Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma

1 reference

7 January 2021

Anti-K-ras ribozyme induces growth inhibition and increased chemosensitivity in human colon cancer cells.

1 reference

7 January 2021

Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice

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7 January 2021

Therapeutic efficacy of an adenovirus-mediated anti-H-ras ribozyme in experimental bladder cancer

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7 January 2021

Preclinical study on gene therapy of cervical carcinoma using adeno-associated virus vectors

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7 January 2021

Inhibition of cell proliferation in HCC-9204 hepatoma cells by a c-myc specific ribozyme.

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7 January 2021

Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

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7 January 2021

Cytochrome P450-based cancer gene therapy: recent advances and future prospects

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7 January 2021

Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma

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7 January 2021

Gene therapy of metastatic colon carcinoma: regression of multiple hepatic metastases by adenoviral expression of bacterial cytosine deaminase

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7 January 2021

Genetic prodrug activation therapy for breast cancer: A phase I clinical trial of erbB-2-directed suicide gene expression

1 reference

7 January 2021

Expression of herpes simplex virus-thymidine kinase gene controlled by a promoter region of the midkine gene confers selective cytotoxicity to ganciclovir in human carcinoma cells

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7 January 2021

Robust prostate-specific expression for targeted gene therapy based on the human kallikrein 2 promoter

1 reference

7 January 2021

Osteocalcin-directed gene therapy for prostate-cancer bone metastasis

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7 January 2021

A novel, conditionally replicative adenovirus for the treatment of breast cancer that allows controlled replication of E1a-deleted adenoviral vectors

1 reference

7 January 2021

The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters

1 reference

7 January 2021

Adenoviral-mediated gene therapy for thyroid carcinoma using thymidine kinase controlled by thyroglobulin promoter demonstrates high specificity and low toxicity

1 reference

7 January 2021

Adenovirus-mediated gene therapy specific for small cell lung cancer cells using a Myc-Max binding motif

1 reference

7 January 2021

Enhanced selective gene expression by adenovirus vector using Cre/loxP regulation system for human carcinoembryonic antigen-producing carcinoma

1 reference

7 January 2021

Tumor-specific gene expression in carcinoembryonic antigen--producing gastric cancer cells using adenovirus vectors

1 reference

7 January 2021

Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine

1 reference

7 January 2021

Selective astrocytic transgene expression in vitro and in vivo from the GFAP promoter in a HSV RL1 null mutant vector--potential glioblastoma targeting

1 reference

7 January 2021

Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector.

1 reference

7 January 2021

Usefulness of a mouse myelin basic protein promoter for gene therapy of malignant glioma: myelin basic protein promoter is strongly active in human malignant glioma cells

1 reference

7 January 2021

Use of von Willebrand factor promoter to transduce suicidal gene to human endothelial cells, HUVEC.

1 reference

7 January 2021

Breast cancer-specific expression of the Candida albicans cytosine deaminase gene using a transcriptional targeting approach

1 reference

7 January 2021

Identifiers

DOI

10.1038/35101008

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Dimensions Publication ID

3 August 2017

1032458985

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Fatcat ID

release_36fktcx4vfbk5cu3qcfyt2uzbu

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/36fktcx4vfbk5cu3qcfyt2uzbu

24 November 2022

mapped directly with Wikidata item

1 reference