(Q34634307)

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Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling

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Europe PubMed Central

PubMed publication ID

3 August 2017

Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

phosphorylation

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Hui-Ju Hsieh

5

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author name string

Bo Zhang

1

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Europe PubMed Central

PubMed publication ID

3 August 2017

Edward Wang

2

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Europe PubMed Central

PubMed publication ID

3 August 2017

Hui Dai

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Jianfeng Shen

4

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Europe PubMed Central

PubMed publication ID

3 August 2017

Xiongbin Lu

6

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Europe PubMed Central

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3 August 2017

Guang Peng

7

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Europe PubMed Central

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3 August 2017

language of work or name

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publication date

9 October 2014

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Europe PubMed Central

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3 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

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3 August 2017

289

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Europe PubMed Central

PubMed publication ID

3 August 2017

49

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Europe PubMed Central

PubMed publication ID

3 August 2017

34284-34295

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Genome-wide transcriptome profiling of homologous recombination DNA repair

1 reference

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7 July 2018

MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

ATR autophosphorylation as a molecular switch for checkpoint activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

The DNA Damage Response: Making It Safe to Play with Knives

1 reference

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7 July 2018

ATR: a master conductor of cellular responses to DNA replication stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Microcephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation

1 reference

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7 July 2018

The DNA-damage response in human biology and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

BRIT1/MCPH1 links chromatin remodelling to DNA damage response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Activation of ATR and related PIKKs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

ATR: an essential regulator of genome integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

The DNA damage response: ten years after

1 reference

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7 July 2018

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Regulation of mitotic entry by microcephalin and its overlap with ATR signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

The DNA damage response during DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Replication protein A-mediated recruitment and activation of Rad17 complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

The BRCT Domain Is a Phospho-Protein Binding Domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Multiple tumor suppressor pathways negatively regulate telomerase

1 reference

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7 July 2018

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

1 reference

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7 July 2018

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

MDC1 is a mediator of the mammalian DNA damage checkpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

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7 July 2018

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

1 reference

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7 July 2018

Checking on the fork: the DNA-replication stress-response pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Identification of microcephalin, a protein implicated in determining the size of the human brain

1 reference

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7 July 2018

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

1 reference

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7 July 2018

Genomic instability in mice lacking histone H2AX

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

ATR and ATRIP: partners in checkpoint signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4256359

7 July 2018

Megabase chromatin domains involved in DNA double-strand breaks in vivo

1 reference

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7 July 2018

Frequent alterations of MCPH1 and ATM are associated with primary breast carcinoma: clinical and prognostic implications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.587113

21 January 2018

Identifiers

10.1074/JBC.M114.587113

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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