(Q34636939)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17565155%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

title

Structural basis for depletion of heat shock protein 90 client proteins by deguelin (English)

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31 December 2019

2

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31 December 2019

11

Waun Ki Hong

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31 December 2019

author name string

Seung Hyun Oh

1

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31 December 2019

Yasemin Dakak Yazici

3

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31 December 2019

Jeffrey N Myers

4

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31 December 2019

Woo-Young Kim

5

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31 December 2019

Quanri Jin

6

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31 December 2019

Soon Sun Hong

7

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31 December 2019

Hyun-Ju Park

8

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31 December 2019

Young-Ger Suh

9

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31 December 2019

Kyu-Won Kim

10

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31 December 2019

Ho-Young Lee

12

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31 December 2019

language of work or name

English

0 references

publication date

12 June 2007

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Journal of the National Cancer Institute

31 December 2019

published in

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31 December 2019

volume

99

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31 December 2019

issue

12

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31 December 2019

page(s)

949-961

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STI571: an inhibitor of the BCR-ABL tyrosine kinase for the treatment of chronic myelogenous leukaemia

31 December 2019

cites work

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Her2-targeted therapies in non-small cell lung cancer

21 January 2018

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21 January 2018

Heat shock protein 90.

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Structure and in vivo function of Hsp90.

21 January 2018

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Induction of heat-shock protein synthesis and thermotolerance in EL-4 ascites tumor cells by transient ATP depletion after ischemic stress.

21 January 2018

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Inhibitors of the HSP90 molecular chaperone: current status

21 January 2018

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Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors.

21 January 2018

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Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update

21 January 2018

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A phase II trial of 17-allylamino-17- demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer

21 January 2018

1 reference

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Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells

21 January 2018

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Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis.

21 January 2018

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Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells

21 January 2018

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Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats

21 January 2018

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Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer.

21 January 2018

1 reference

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Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

21 January 2018

1 reference

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Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

21 January 2018

1 reference

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Effects of insulin-like growth factor binding protein-3 and farnesyltransferase inhibitor SCH66336 on Akt expression and apoptosis in non-small-cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJM007

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJM007

Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJM007

Restart procedures for the conjugate gradient method

21 January 2018

1 reference

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

1 reference

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Consensus scoring for ligand/protein interactions

21 January 2018

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Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors

21 January 2018

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Targeting HIF-1 for cancer therapy

21 January 2018

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJM007

Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJM007

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

21 January 2018

1 reference

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Hypoxia--a key regulatory factor in tumour growth

21 January 2018

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HIF-1 and tumor progression: pathophysiology and therapeutics

21 January 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJM007

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

21 January 2018

1 reference

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Interaction of the PAS B domain with HSP90 accelerates hypoxia-inducible factor-1alpha stabilization.

21 January 2018

1 reference

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A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJM007

Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJM007

Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJM007

Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification

21 January 2018

1 reference

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Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

21 January 2018

1 reference

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Heat shock protein 90 as a molecular target for cancer therapeutics

21 January 2018

1 reference

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Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

21 January 2018

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Precise destruction: an emerging picture of the APC.

21 January 2018

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 January 2018

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Hsp90: an emerging target for breast cancer therapy

21 January 2018

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Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90

21 January 2018

1 reference

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Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJM007

Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJM007

21 January 2018

Identifiers

DOI

10.1093/JNCI/DJM007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17565155%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference