(Q34649934)

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Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models.

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27 February 2020

Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models (English)

1 reference

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27 February 2020

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based on heuristic

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based on heuristic

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3

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27 February 2020

4

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27 February 2020

Marileila Varella-Garcia

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Marileila Varella-Garcia

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27 February 2020

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Todd M Pitts

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27 February 2020

S Gail Eckhardt

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S Gail Eckhardt

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27 February 2020

Wells A Messersmith

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Wells A Messersmith

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27 February 2020

author name string

Gillian N Kulikowski

2

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27 February 2020

John J Arcaroli

5

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27 February 2020

John J Tentler

6

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27 February 2020

Anna Spreafico

7

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27 February 2020

Heather M Selby

8

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27 February 2020

Maria I Kachaeva

9

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27 February 2020

Kelly L McPhillips

10

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27 February 2020

Blair C Britt

11

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27 February 2020

Erica L Bradshaw-Pierce

12

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27 February 2020

publication date

28 March 2013

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27 February 2020

Frontiers in Pharmacology

1 reference

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27 February 2020

4

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27 February 2020

35

1 reference

Europe PubMed Central

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27 February 2020

Regorafenib (BAY 73-4506) in advanced colorectal cancer: a phase I study

1 reference

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7 July 2018

Role of angiogenesis inhibitors in colorectal cancer: sensitive and insensitive tumors.

1 reference

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7 July 2018

P21-activated kinase 4 overexpression in metastatic gastric cancer patients

1 reference

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7 July 2018

Nucleo-cytoplasmic shuttling of PAK4 modulates β-catenin intracellular translocation and signaling

1 reference

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7 July 2018

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

1 reference

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7 July 2018

P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth.

1 reference

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7 July 2018

Vemurafenib (PLX4032): an orally available inhibitor of mutated BRAF for the treatment of metastatic melanoma

1 reference

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Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis

1 reference

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7 July 2018

A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells

1 reference

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7 July 2018

Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer

1 reference

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7 July 2018

Global cancer statistics

1 reference

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7 July 2018

Do PAKs make good drug targets?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

New strategies for treatment of KRAS mutant metastatic colorectal cancer

1 reference

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7 July 2018

Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

The emerging importance of group II PAKs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

Current progress in targeted therapy for colorectal cancer

1 reference

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7 July 2018

Biomarkers of Resistance to Epidermal Growth Factor Receptor Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer

1 reference

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7 July 2018

KRAS mutation in colon cancer: a marker of resistance to EGFR-I therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

PAK signaling in oncogenesis.

1 reference

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7 July 2018

MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents

1 reference

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7 July 2018

Elevated p21-activated kinase 2 activity results in anchorage-independent growth and resistance to anticancer drug-induced cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

Targeting group II PAKs in cancer and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

Critical role of vimentin phosphorylation at Ser-56 by p21-activated kinase in vimentin cytoskeleton signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

p21-activated kinases in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610060

7 July 2018

Complex networks orchestrate epithelial-mesenchymal transitions

1 reference

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7 July 2018

Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.

1 reference

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7 July 2018

Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients

1 reference

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7 July 2018

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1 reference

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7 July 2018

p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest

1 reference

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7 July 2018

Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines

1 reference

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7 July 2018

Activated PAK4 regulates cell adhesion and anchorage-independent growth

1 reference

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7 July 2018

The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis

1 reference

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7 July 2018

The Akt proto-oncogene links Ras to Pak and cell survival signals

1 reference

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7 July 2018

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

1 reference

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Activation of PI3 kinase/Akt/HIF-1α pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma.

1 reference

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1 reference

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1 reference

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12 December 2020

based on heuristic

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Identifiers

10.3389/FPHAR.2013.00035

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27 February 2020

1 reference

Europe PubMed Central

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27 February 2020

1 reference

Europe PubMed Central

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27 February 2020

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