(Q34655627)

3 August 2017

title

The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo (English)

1 reference

3 August 2017

Robert L Kortum

1

1 reference

3 August 2017

Lakshmi Balagopalan

2

1 reference

3 August 2017

Clayton P Alexander

3

1 reference

3 August 2017

Julie Garcia

4

1 reference

3 August 2017

John M Pinski

5

1 reference

3 August 2017

Robert K Merrill

6

1 reference

3 August 2017

Phan H Nguyen

7

1 reference

3 August 2017

Wenmei Li

8

1 reference

3 August 2017

Isha Agarwal

9

1 reference

3 August 2017

Itoro O Akpan

10

1 reference

3 August 2017

Connie L Sommers

11

1 reference

3 August 2017

Lawrence E Samelson

12

1 reference

3 August 2017

publication date

12 November 2013

1 reference

3 August 2017

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3 August 2017

volume

6

1 reference

3 August 2017

issue

301

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3 August 2017

page(s)

ra99

1 reference

describes a project that uses

3 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4259567/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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7 July 2018

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7 July 2018

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Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling

7 July 2018

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Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

7 July 2018

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Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner

7 July 2018

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7 July 2018

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7 July 2018

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

7 July 2018

1 reference

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Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2.

7 July 2018

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The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development

7 July 2018

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Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor

7 July 2018

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An orthosteric inhibitor of the Ras-Sos interaction

7 July 2018

1 reference

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Targeted Sos1 deletion reveals its critical role in early T-cell development

7 July 2018

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The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

7 July 2018

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Ligand-induced EGF receptor oligomerization is kinase-dependent and enhances internalization

7 July 2018

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Decision checkpoints in the thymus

7 July 2018

1 reference

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The LAT story: a tale of cooperativity, coordination, and choreography

7 July 2018

1 reference

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Digital signaling and hysteresis characterize ras activation in lymphoid cells

7 July 2018

1 reference

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Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: application to adaptor protein complexes in cell signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways

7 July 2018

1 reference

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Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development.

7 July 2018

1 reference

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14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.

7 July 2018

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties

7 July 2018

1 reference

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Activation-dependent clustering of the erbB2 receptor tyrosine kinase detected by scanning near-field optical microscopy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

Surface expression and functional competence of CD3-independent TCR zeta-chains in immature thymocytes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

Differential effects of zeta and eta transgenes on early alpha/beta T cell development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259567

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

7 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004494

Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004494

Common and distinct elements in cellular signaling via EGF and FGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004494

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004494

Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004494

High-resolution multicolor imaging of dynamic signaling complexes in T cells stimulated by planar substrates

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24222714

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCISIGNAL.2004494

1 reference

3 August 2017

1 reference

3 August 2017

1 reference