(Q34656836)

3 August 2017

title

CDK5 is a major regulator of the tumor suppressor DLC1 (English)

1 reference

3 August 2017

Brajendra K Tripathi

1

1 reference

3 August 2017

Xiaolan Qian

2

1 reference

3 August 2017

Philipp Mertins

3

1 reference

3 August 2017

Dunrui Wang

4

1 reference

3 August 2017

Alex G Papageorge

5

1 reference

3 August 2017

Steven A Carr

6

1 reference

3 August 2017

Douglas R Lowy

7

1 reference

3 August 2017

language of work or name

English

0 references

publication date

1 December 2014

1 reference

3 August 2017

number of pages

16

1 reference

based on heuristic

inferred from page(s)

published in

Journal of Cell Biology

1 reference

3 August 2017

volume

207

1 reference

3 August 2017

issue

5

1 reference

3 August 2017

page(s)

627-642

1 reference

describes a project that uses

3 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4259810/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Regulation of deleted in liver cancer 1 tumor suppressor by protein-protein interactions and phosphorylation

7 July 2018

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CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth

7 July 2018

1 reference

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Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation

7 July 2018

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TGFβ signalling in context

7 July 2018

1 reference

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Level of cdk5 expression predicts the survival of relapsed multiple myeloma patients

7 July 2018

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7 July 2018

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7 July 2018

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Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation

7 July 2018

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Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

7 July 2018

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7 July 2018

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7 July 2018

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Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression

7 July 2018

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Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling

7 July 2018

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DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration

7 July 2018

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Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform

7 July 2018

1 reference

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7 July 2018

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Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP

7 July 2018

1 reference

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The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis

7 July 2018

1 reference

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Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.

7 July 2018

1 reference

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Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility

7 July 2018

1 reference

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Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration

7 July 2018

1 reference

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Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

7 July 2018

1 reference

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Rho GTPases in cancer cell biology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

The Cdk5 inhibitor olomoucine promotes corneal debridement wound closure in vivo.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Rho GTPases: functions and association with cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

In-gel digestion for mass spectrometric characterization of proteins and proteomes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

7 July 2018

The many faces of SAM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Cancer genes and the pathways they control

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Cdk5 phosphorylates p53 and regulates its activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259810

Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth.

7 July 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201405105

The cyclin-dependent kinase inhibitor roscovitine inhibits kinase activity, cell proliferation, multicellular development, and Cdk5 nuclear translocation in Dictyostelium discoideum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201405105

Expression of CDK5/p35 in resected patients with non-small cell lung cancer: relation to prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201405105

Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201405105

Regulation of the interaction of Disabled-1 with CIN85 by phosphorylation with Cyclin-dependent kinase 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201405105

Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25452387

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.201405105

1 reference

3 August 2017

1 reference

3 August 2017

1 reference