(Q34656871)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

0 references

3

1 reference

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28 February 2020

Alessandro Giuliani

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Vito Antonio Baldassarro

7

1 reference

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28 February 2020

Chiara Mangano

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Luca Ferraro

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Vladimiro Pietrini

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Bruno Imbimbo

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Luciana Giardino

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Luca Lorenzini

2

1 reference

ORCID Public Data File 2021

author name string

Sandra Sivilia

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Marco Gusciglio

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Mercedes Fernandez

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Maria Francesca Baroc

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Arturo R Viscomi

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Simone Ottonello

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Gino Villetti

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Laura Calzà

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

publication date

5 April 2013

1 reference

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28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

volume

14

1 reference

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28 February 2020

page(s)

44

1 reference

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https://scigraph.springernature.com/pub.10.1186/1471-2202-14-44

28 February 2020

exact match

0 references

cites work

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease.

7 July 2018

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7 July 2018

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Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice

7 July 2018

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7 July 2018

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Alzheimer's disease: clinical trials and drug development

7 July 2018

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Pathological implications of cell cycle re-entry in Alzheimer disease

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

1 reference

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Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein

7 July 2018

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1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.

7 July 2018

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7 July 2018

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7 July 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

7 July 2018

1 reference

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Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

7 July 2018

1 reference

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Neuronal structure is altered by amyloid plaques

7 July 2018

1 reference

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The cell cycle and human neurodegenerative disease

7 July 2018

1 reference

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Intracellular A-beta amyloid, a sign for worse things to come?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626610

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626610

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626610

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626610

Mapping the road forward in Alzheimer's disease

7 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

Region-specific changes in the microanatomy of single dendritic spines over time might account for selective memory alterations in ageing hAPPsweTg2576 mice, a mouse model for Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

Dynamics of learning-induced spine redistribution along dendrites of pyramidal neurons in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

What the halted phase III γ-secretase inhibitor trial may (or may not) be telling us.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

Consistent immunohistochemical detection of intracellular beta-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2202-14-44

Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626610

The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626610

Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626610

Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626610

CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626610

Semagacestat, a gamma-secretase inhibitor for the potential treatment of Alzheimer's disease.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626610

Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626610

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626610

26 October 2018

Identifiers

DOI

10.1186/1471-2202-14-44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

28 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23560952%20AND%20SRC:MED&resulttype=core&format=json