(Q34688638)

3 August 2017

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title

Telomerase inhibition and the future management of head-and-neck cancer (English)

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3 August 2017

James A McCaul

1

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3 August 2017

Katrina E Gordon

series ordinal

2

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3 August 2017

Louise J Clark

series ordinal

3

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3 August 2017

E Kenneth Parkinson

series ordinal

4

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3 August 2017

publication date

1 May 2002

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Lancet Oncology Commission

3 August 2017

published in

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3 August 2017

volume

3

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3 August 2017

issue

5

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3 August 2017

page(s)

280-288

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Genetic mechanisms in squamous cell carcinoma of the head and neck

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Is telomerase a universal cancer target?

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7 January 2021

Do telomerase antagonists represent a novel anti-cancer strategy?

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomerase: biology and phase I trials

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7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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7 January 2021

Telomerase still 'investigational' in its application to cancer management

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomeres and their control

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7 January 2021

Telomeres and telomerase

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomere position effect in human cells

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Origin of Concatemeric T7DNA

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomeres, telomerase, and myc. An update

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomere length predicts replicative capacity of human fibroblasts

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

The RNA component of human telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomerase catalytic subunit homologs from fission yeast and human

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Extension of cell life-span and telomere length in animals cloned from senescent somatic cells

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomere reduction in human colorectal carcinoma and with ageing

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomeres shorten during ageing of human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

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7 January 2021

Hypervariable ultra-long telomeres in mice

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https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Essential role of mouse telomerase in highly proliferative organs

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

A telomerase component is defective in the human disease dyskeratosis congenita

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Creation of human tumour cells with defined genetic elements

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Mice without telomerase: what can they teach us about human cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

In vivo loss of telomeric repeats with age in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomerase activity in melanoma and non-melanoma skin cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Inhibition of telomerase limits the growth of human cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

A highly selective telomerase inhibitor limiting human cancer cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

An alternative pathway for yeast telomere maintenance rescues est1- senescence

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Alternative lengthening of telomeres in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Defects in mismatch repair promote telomerase-independent proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Microsatellite analysis and response to chemotherapy in head-and-neck squamous-cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

Angiogenesis in cancer and other diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2802%2900729-5

7 January 2021

10.1016/S1470-2045(02)00729-5

Identifiers

DOI

1 reference

3 August 2017

1 reference