(Q34695283)

4 August 2017

Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor (English)

1 reference

4 August 2017

0 references

Almer M van der Sloot

Almer M van der Sloot

1

0 references

Eva Szegezdi

Eva Szegezdi

3

0 references

Robbert H Cool

Robbert H Cool

5

0 references

Afshin Samali

Afshin Samali

6

0 references

author name string

Vicente Tur

2

1 reference

4 August 2017

Margaret M Mullally

4

1 reference

4 August 2017

Luis Serrano

7

1 reference

4 August 2017

Wim J Quax

8

1 reference

4 August 2017

language of work or name

English

0 references

publication date

26 May 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

4 August 2017

1 reference

4 August 2017

103

1 reference

4 August 2017

8634-8639

1 reference

4 August 2017

23

1 reference

Computer modelling in combination with in vitro studies reveals similar binding affinities of Drosophila Crumbs for the PDZ domains of Stardust and DmPar-6.

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Prediction of water and metal binding sites and their affinities by using the Fold-X force field

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Following a TRAIL: update on a ligand and its five receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Stabilization of TRAIL, an all-beta-sheet multimeric protein, using computational redesign.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Inactivation of TNF signaling by rationally designed dominant-negative TNF variants

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Apo2L/TRAIL and its death and decoy receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

The molecular architecture of the TNF superfamily

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

The TNF and TNF receptor superfamilies: integrating mammalian biology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Crystal structure of TRAIL-DR5 complex identifies a critical role of the unique frame insertion in conferring recognition specificity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Safety and antitumor activity of recombinant soluble Apo2 ligand

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

WHAT IF: a molecular modeling and drug design program

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Modulating calmodulin binding specificity through computational protein design

7 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510187103

Automated design of specificity in molecular recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510187103

Computational redesign of protein-protein interaction specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510187103

A detailed thermodynamic analysis of ras/effector complex interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510187103

Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510187103

Computer-aided design of a PDZ domain to recognize new target sequences.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1482632

Recognizing and Defining True Ras Binding Domains II: In Silico Prediction Based on Homology Modelling and Energy Calculations

26 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510187103

Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510187103

Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510187103

The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510187103

Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0510187103

Functional analysis of TRAIL receptors using monoclonal antibodies

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16731632

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0510187103

1 reference

release_c3ghdo2verh5ldkep6u42x5pue

4 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/c3ghdo2verh5ldkep6u42x5pue

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMCID

1482632

1 reference

4 August 2017

1 reference